Estimation of some biochemical markers in acute myeloid leukemic patients before and after chemotherapy
The aim of this study was to measure the levels of malondialdehyde (MDA), peroxynitrite (PN), homocysteine (HCY), and uric acid (UA) in acute myeloid leukemic patients (AML) (before and after taking chemotherapy) and compare results with a healthy control group. The present study includes 120 age r...
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University of Baghdad, College of Science for Women
2024-08-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8282 |
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| author | Ayinda Mariwan Mohsen Zeyan Abdullah Ali |
| author_facet | Ayinda Mariwan Mohsen Zeyan Abdullah Ali |
| author_sort | Ayinda Mariwan Mohsen |
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The aim of this study was to measure the levels of malondialdehyde (MDA), peroxynitrite (PN), homocysteine (HCY), and uric acid (UA) in acute myeloid leukemic patients (AML) (before and after taking chemotherapy) and compare results with a healthy control group. The present study includes 120 age ranged 18-70 years old suffered from AML as well as 40 healthy group. Subjects were collected from patients and a control group at Erbil’s Nanakali Hospital, they were classified into four groups: Group 1 (G1) which includes 40 healthy subjects, Group 2 (G2) includes 40 AML patients before taking chemotherapy (newly diagnosed cases), Group 3 (G3) includes 40 AML patients after taking chemotherapy (one cycle) and Group 4 (G4) includes 40 AML patients after taking chemotherapy (more than one cycle). The results have shown a high significantly increased in levels of (MDA and UA), and significantly increased in PN in all patient groups (G1, G2, and G3) when compared to (G1). While homocysteine was a high significantly increased in (G2) when compared to (G1), and high significantly decreased in (G3 and G4) as compared to (G1). Additionally, the correlation analysis has shown that there was a significant positive correlation between malondialdehyde and peroxynitrite (r=0.4638), malondialdehyde and homocysteine (r=0.4752), and malondialdehyde with uric acid (r=0.3621). A high area under the curve of our data suggests that the determination of these parameters could be helpful to detect AML
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| format | Article |
| id | doaj-art-cc7ba44194d5465ea6125dd288ea9bb7 |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | University of Baghdad, College of Science for Women |
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| series | مجلة بغداد للعلوم |
| spelling | doaj-art-cc7ba44194d5465ea6125dd288ea9bb72025-08-20T03:18:09ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-08-0121810.21123/bsj.2024.8282Estimation of some biochemical markers in acute myeloid leukemic patients before and after chemotherapyAyinda Mariwan Mohsen0https://orcid.org/0000-0002-1000-0499Zeyan Abdullah Ali1https://orcid.org/0000-0001-8978-6377Department of chemistry, College of Education, Salahaddin University, Erbil, Iraq.Department of chemistry, College of Education, Salahaddin University, Erbil, Iraq. The aim of this study was to measure the levels of malondialdehyde (MDA), peroxynitrite (PN), homocysteine (HCY), and uric acid (UA) in acute myeloid leukemic patients (AML) (before and after taking chemotherapy) and compare results with a healthy control group. The present study includes 120 age ranged 18-70 years old suffered from AML as well as 40 healthy group. Subjects were collected from patients and a control group at Erbil’s Nanakali Hospital, they were classified into four groups: Group 1 (G1) which includes 40 healthy subjects, Group 2 (G2) includes 40 AML patients before taking chemotherapy (newly diagnosed cases), Group 3 (G3) includes 40 AML patients after taking chemotherapy (one cycle) and Group 4 (G4) includes 40 AML patients after taking chemotherapy (more than one cycle). The results have shown a high significantly increased in levels of (MDA and UA), and significantly increased in PN in all patient groups (G1, G2, and G3) when compared to (G1). While homocysteine was a high significantly increased in (G2) when compared to (G1), and high significantly decreased in (G3 and G4) as compared to (G1). Additionally, the correlation analysis has shown that there was a significant positive correlation between malondialdehyde and peroxynitrite (r=0.4638), malondialdehyde and homocysteine (r=0.4752), and malondialdehyde with uric acid (r=0.3621). A high area under the curve of our data suggests that the determination of these parameters could be helpful to detect AML https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8282Acute myeloid leukemia, homocysteine, malondialdehyde, peroxynitrite, uric acid |
| spellingShingle | Ayinda Mariwan Mohsen Zeyan Abdullah Ali Estimation of some biochemical markers in acute myeloid leukemic patients before and after chemotherapy مجلة بغداد للعلوم Acute myeloid leukemia, homocysteine, malondialdehyde, peroxynitrite, uric acid |
| title | Estimation of some biochemical markers in acute myeloid leukemic patients before and after chemotherapy |
| title_full | Estimation of some biochemical markers in acute myeloid leukemic patients before and after chemotherapy |
| title_fullStr | Estimation of some biochemical markers in acute myeloid leukemic patients before and after chemotherapy |
| title_full_unstemmed | Estimation of some biochemical markers in acute myeloid leukemic patients before and after chemotherapy |
| title_short | Estimation of some biochemical markers in acute myeloid leukemic patients before and after chemotherapy |
| title_sort | estimation of some biochemical markers in acute myeloid leukemic patients before and after chemotherapy |
| topic | Acute myeloid leukemia, homocysteine, malondialdehyde, peroxynitrite, uric acid |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8282 |
| work_keys_str_mv | AT ayindamariwanmohsen estimationofsomebiochemicalmarkersinacutemyeloidleukemicpatientsbeforeandafterchemotherapy AT zeyanabdullahali estimationofsomebiochemicalmarkersinacutemyeloidleukemicpatientsbeforeandafterchemotherapy |