An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan.

An insulin-sensitive Drosophila insulin-like receptor mutant remodels methionine metabolism to extend lifespan.

Insulin/insulin growth factor signaling is a conserved pathway that regulates lifespan across many species. Multiple mechanisms are proposed for how this altered signaling slows aging. To elaborate these causes, we recently developed a series of Drosophila insulin-like receptor (dInr) mutants with s...

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Main Authors: Marc Tatar, Wenjing Zheng, Shweta Yadav, Rochele Yamamoto, Noelle Curtis-Joseph, Shengxi Li, Lin Wang, Andrey A Parkhitko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011640
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