Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysis
Abstract Purpose This study aims to identify the risk factors for the progression from pulmonary tuberculosis (PTB) to spinal tuberculosis (STB), which is crucial for early disease intervention, optimizing treatment strategies, and improving patient prognosis. Methods A retrospective analysis was co...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
|
| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-025-05848-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849314727952384000 |
|---|---|
| author | Di Xue Xiaolei Chen Lufei Shao Qinfu Liu Jia Chen Yajing Su Chen Zhang Zhirong Chen Min Su Zhiqiang Wu Yiqiang Yang Xue Lin |
| author_facet | Di Xue Xiaolei Chen Lufei Shao Qinfu Liu Jia Chen Yajing Su Chen Zhang Zhirong Chen Min Su Zhiqiang Wu Yiqiang Yang Xue Lin |
| author_sort | Di Xue |
| collection | DOAJ |
| description | Abstract Purpose This study aims to identify the risk factors for the progression from pulmonary tuberculosis (PTB) to spinal tuberculosis (STB), which is crucial for early disease intervention, optimizing treatment strategies, and improving patient prognosis. Methods A retrospective analysis was conducted on 326 patients diagnosed with PTB between January 2017 and October 2024. Demographic, clinical, and socioeconomic data were collected, including age, gender, body mass index (BMI), Karnofsky Performance Status (KPS), Nutritional Risk Screening 2002 (NRS-2002) score, diabetes, per capita income, smoking status, alcohol consumption, and a history of recurrent PTB. Univariate and multivariate logistic regression analyses were performed to identify significant risk factors for the progression to STB, and interaction effect analysis and risk stratification based on the NRS-2002 score were conducted to assess its predictive value. Results Univariate logistic regression revealed that the NRS-2002 score (OR = 2.762, p < 0.001), recurrent PTB (OR = 15.370, p < 0.001), and living in relative poverty (OR = 10.000, p = 0.002) were significant risk factors for the progression from PTB to STB. Multivariate logistic regression confirmed that the NRS-2002 score (OR = 11.22, p < 0.001), recurrent PTB (OR = 5.08, p < 0.001), and living in relative poverty (OR = 2.58, p < 0.001) were independently associated with increased likelihood of STB progression. Stratified analysis revealed a clear dose-response relationship between higher NRS-2002 scores and the risk of progression to STB, with those having scores ≥ 6 exhibiting the highest odds (OR = 91.59, p < 0.001). Conclusions This study highlights critical risk factors for the progression from PTB to STB, particularly the NRS-2002 score, recurrent PTB, and socioeconomic status (living in relative poverty). The NRS-2002 score was identified as the most significant predictor, demonstrating a strong dose-response relationship with disease progression. Clinically, early identification of patients with elevated NRS-2002 scores, alongside timely nutritional interventions and efforts to alleviate poverty, can significantly reduce the risk of STB development. These findings can inform clinical decision-making, enhance early intervention strategies, and guide public health policies aimed at preventing STB, particularly in high-risk populations. |
| format | Article |
| id | doaj-art-cc6599eb13904a2899f041ec0ea8c09c |
| institution | Kabale University |
| issn | 1749-799X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj-art-cc6599eb13904a2899f041ec0ea8c09c2025-08-20T03:52:23ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2025-04-012011910.1186/s13018-025-05848-3Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysisDi Xue0Xiaolei Chen1Lufei Shao2Qinfu Liu3Jia Chen4Yajing Su5Chen Zhang6Zhirong Chen7Min Su8Zhiqiang Wu9Yiqiang Yang10Xue Lin11Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, Institute of Medical Sciences, General Hospital of Ningxia Medical UniversityThe Orthopaedic department, General Hospital of Ningxia Medical UniversityThe Neurology department, General Hospital of Ningxia Medical UniversityThe ICU department General Hospital of Ningxia Medical UniversityDepartment of Orthodontics, Stomatological Hospital, General Hospital of Ningxia Medical UniversityNingxia Key Laboratory of Clinical and Pathogenic Microbiology, Institute of Medical Sciences, General Hospital of Ningxia Medical UniversitySchool of Education, Ningxia UniversityThe Orthopaedic department, General Hospital of Ningxia Medical UniversityDepartment of Orthopaedics, The First Affiliated Hospital of Fujian Medical UniversityDepartment of Orthopedics, Quanzhou Orthopedic-Traumatological HospitalDepartment of Orthodontics, Stomatological Hospital, General Hospital of Ningxia Medical UniversityNingxia Key Laboratory of Clinical and Pathogenic Microbiology, Institute of Medical Sciences, General Hospital of Ningxia Medical UniversityAbstract Purpose This study aims to identify the risk factors for the progression from pulmonary tuberculosis (PTB) to spinal tuberculosis (STB), which is crucial for early disease intervention, optimizing treatment strategies, and improving patient prognosis. Methods A retrospective analysis was conducted on 326 patients diagnosed with PTB between January 2017 and October 2024. Demographic, clinical, and socioeconomic data were collected, including age, gender, body mass index (BMI), Karnofsky Performance Status (KPS), Nutritional Risk Screening 2002 (NRS-2002) score, diabetes, per capita income, smoking status, alcohol consumption, and a history of recurrent PTB. Univariate and multivariate logistic regression analyses were performed to identify significant risk factors for the progression to STB, and interaction effect analysis and risk stratification based on the NRS-2002 score were conducted to assess its predictive value. Results Univariate logistic regression revealed that the NRS-2002 score (OR = 2.762, p < 0.001), recurrent PTB (OR = 15.370, p < 0.001), and living in relative poverty (OR = 10.000, p = 0.002) were significant risk factors for the progression from PTB to STB. Multivariate logistic regression confirmed that the NRS-2002 score (OR = 11.22, p < 0.001), recurrent PTB (OR = 5.08, p < 0.001), and living in relative poverty (OR = 2.58, p < 0.001) were independently associated with increased likelihood of STB progression. Stratified analysis revealed a clear dose-response relationship between higher NRS-2002 scores and the risk of progression to STB, with those having scores ≥ 6 exhibiting the highest odds (OR = 91.59, p < 0.001). Conclusions This study highlights critical risk factors for the progression from PTB to STB, particularly the NRS-2002 score, recurrent PTB, and socioeconomic status (living in relative poverty). The NRS-2002 score was identified as the most significant predictor, demonstrating a strong dose-response relationship with disease progression. Clinically, early identification of patients with elevated NRS-2002 scores, alongside timely nutritional interventions and efforts to alleviate poverty, can significantly reduce the risk of STB development. These findings can inform clinical decision-making, enhance early intervention strategies, and guide public health policies aimed at preventing STB, particularly in high-risk populations.https://doi.org/10.1186/s13018-025-05848-3Pulmonary tuberculosisSpinal tuberculosisLogistic regressionRecurrent pulmonary tuberculosisRisk stratification |
| spellingShingle | Di Xue Xiaolei Chen Lufei Shao Qinfu Liu Jia Chen Yajing Su Chen Zhang Zhirong Chen Min Su Zhiqiang Wu Yiqiang Yang Xue Lin Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysis Journal of Orthopaedic Surgery and Research Pulmonary tuberculosis Spinal tuberculosis Logistic regression Recurrent pulmonary tuberculosis Risk stratification |
| title | Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysis |
| title_full | Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysis |
| title_fullStr | Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysis |
| title_full_unstemmed | Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysis |
| title_short | Risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis: a logistic regression analysis |
| title_sort | risk factors for the progression from pulmonary tuberculosis to spinal tuberculosis a logistic regression analysis |
| topic | Pulmonary tuberculosis Spinal tuberculosis Logistic regression Recurrent pulmonary tuberculosis Risk stratification |
| url | https://doi.org/10.1186/s13018-025-05848-3 |
| work_keys_str_mv | AT dixue riskfactorsfortheprogressionfrompulmonarytuberculosistospinaltuberculosisalogisticregressionanalysis AT xiaoleichen riskfactorsfortheprogressionfrompulmonarytuberculosistospinaltuberculosisalogisticregressionanalysis AT lufeishao riskfactorsfortheprogressionfrompulmonarytuberculosistospinaltuberculosisalogisticregressionanalysis AT qinfuliu riskfactorsfortheprogressionfrompulmonarytuberculosistospinaltuberculosisalogisticregressionanalysis AT jiachen riskfactorsfortheprogressionfrompulmonarytuberculosistospinaltuberculosisalogisticregressionanalysis AT yajingsu riskfactorsfortheprogressionfrompulmonarytuberculosistospinaltuberculosisalogisticregressionanalysis AT chenzhang riskfactorsfortheprogressionfrompulmonarytuberculosistospinaltuberculosisalogisticregressionanalysis AT zhirongchen riskfactorsfortheprogressionfrompulmonarytuberculosistospinaltuberculosisalogisticregressionanalysis AT minsu riskfactorsfortheprogressionfrompulmonarytuberculosistospinaltuberculosisalogisticregressionanalysis AT zhiqiangwu riskfactorsfortheprogressionfrompulmonarytuberculosistospinaltuberculosisalogisticregressionanalysis AT yiqiangyang riskfactorsfortheprogressionfrompulmonarytuberculosistospinaltuberculosisalogisticregressionanalysis AT xuelin riskfactorsfortheprogressionfrompulmonarytuberculosistospinaltuberculosisalogisticregressionanalysis |