De Ritis Ratio and related Parameters among Breast Cancer Patients in a Southern Nigeria Population
De Ritis described the ratio between the serum levels of liver enzymes; aspartate transaminase (AST) and alanine transaminase (ALT). The central role of the liver in metabolism makes it a necessity that it functions optimally during chemotherapeutic administration, hence the consideration of associa...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hammer Head Production Limited
2022-08-01
|
| Series: | Sokoto Journal of Medical Laboratory Science |
| Subjects: | |
| Online Access: | https://sokjmls.com.ng/index.php/SJMLS/article/view/70 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849344760088625152 |
|---|---|
| author | Udosen, J.E. , Akwiwu, E.C. *, Akpotuzor, D.U. , Akpotuzor, J.O |
| author_facet | Udosen, J.E. , Akwiwu, E.C. *, Akpotuzor, D.U. , Akpotuzor, J.O |
| author_sort | Udosen, J.E. , Akwiwu, E.C. *, Akpotuzor, D.U. , Akpotuzor, J.O |
| collection | DOAJ |
| description | De Ritis described the ratio between the serum levels of liver enzymes; aspartate transaminase (AST) and alanine transaminase (ALT). The central role of the liver in metabolism makes it a necessity that it functions optimally during chemotherapeutic administration, hence the consideration of associated parameters in the management of breast cancer. This study was conducted in University of Calabar Teaching Hospital, Calabar. It included 40 cases of pathologically diagnosed breast cancer female patients who were accessing post-operative chemotherapy. Another 40 apparently healthy females drawn from the general population served as controls. Ethical approval and written informed consent were duly sought and obtained. The present study measured the levels of total and conjugated bilirubin as well as the enzyme activities for a spartate aminotransferase, alanine aminotransferase and alkaline phosphatase. Additionally, Unconjugated bilirubin derived from total and conjugated bilirubin as well as De Ritis ratio computed from aspartate aminotransferase and alanine aminotransferase were calculated. Standard colorimetric methods were used to determine the measured parameters, while derived parameters were calculated. The data obtained were analyzed in Statistical Package for Social Sciences (SPSS) using students t-test at 95% confidence level with p-value of ≤ 0.05. Apart from alanine aminotransferase that of the chemotherapy courses showed some observable effect on both derived parameters; Unconjugated Bilirubin and De Ritis ratio. The later showed a stable pattern of increment after commen cement of post-operative chemotherapy. This study indicates that routine assessment of hepatic function and De Ritis ratio should be determined as part of breast cancer management. |
| format | Article |
| id | doaj-art-cc6226e2950a4c10826a0dc23cbbafc9 |
| institution | Kabale University |
| issn | 2536-7153 |
| language | English |
| publishDate | 2022-08-01 |
| publisher | Hammer Head Production Limited |
| record_format | Article |
| series | Sokoto Journal of Medical Laboratory Science |
| spelling | doaj-art-cc6226e2950a4c10826a0dc23cbbafc92025-08-20T03:42:35ZengHammer Head Production LimitedSokoto Journal of Medical Laboratory Science2536-71532022-08-017270De Ritis Ratio and related Parameters among Breast Cancer Patients in a Southern Nigeria PopulationUdosen, J.E. , Akwiwu, E.C. *, Akpotuzor, D.U. , Akpotuzor, J.ODe Ritis described the ratio between the serum levels of liver enzymes; aspartate transaminase (AST) and alanine transaminase (ALT). The central role of the liver in metabolism makes it a necessity that it functions optimally during chemotherapeutic administration, hence the consideration of associated parameters in the management of breast cancer. This study was conducted in University of Calabar Teaching Hospital, Calabar. It included 40 cases of pathologically diagnosed breast cancer female patients who were accessing post-operative chemotherapy. Another 40 apparently healthy females drawn from the general population served as controls. Ethical approval and written informed consent were duly sought and obtained. The present study measured the levels of total and conjugated bilirubin as well as the enzyme activities for a spartate aminotransferase, alanine aminotransferase and alkaline phosphatase. Additionally, Unconjugated bilirubin derived from total and conjugated bilirubin as well as De Ritis ratio computed from aspartate aminotransferase and alanine aminotransferase were calculated. Standard colorimetric methods were used to determine the measured parameters, while derived parameters were calculated. The data obtained were analyzed in Statistical Package for Social Sciences (SPSS) using students t-test at 95% confidence level with p-value of ≤ 0.05. Apart from alanine aminotransferase that of the chemotherapy courses showed some observable effect on both derived parameters; Unconjugated Bilirubin and De Ritis ratio. The later showed a stable pattern of increment after commen cement of post-operative chemotherapy. This study indicates that routine assessment of hepatic function and De Ritis ratio should be determined as part of breast cancer management.https://sokjmls.com.ng/index.php/SJMLS/article/view/70breast cancer, chemotherapy, de ritis ratio, liver function tests |
| spellingShingle | Udosen, J.E. , Akwiwu, E.C. *, Akpotuzor, D.U. , Akpotuzor, J.O De Ritis Ratio and related Parameters among Breast Cancer Patients in a Southern Nigeria Population Sokoto Journal of Medical Laboratory Science breast cancer, chemotherapy, de ritis ratio, liver function tests |
| title | De Ritis Ratio and related Parameters among Breast Cancer Patients in a Southern Nigeria Population |
| title_full | De Ritis Ratio and related Parameters among Breast Cancer Patients in a Southern Nigeria Population |
| title_fullStr | De Ritis Ratio and related Parameters among Breast Cancer Patients in a Southern Nigeria Population |
| title_full_unstemmed | De Ritis Ratio and related Parameters among Breast Cancer Patients in a Southern Nigeria Population |
| title_short | De Ritis Ratio and related Parameters among Breast Cancer Patients in a Southern Nigeria Population |
| title_sort | de ritis ratio and related parameters among breast cancer patients in a southern nigeria population |
| topic | breast cancer, chemotherapy, de ritis ratio, liver function tests |
| url | https://sokjmls.com.ng/index.php/SJMLS/article/view/70 |
| work_keys_str_mv | AT udosenjeakwiwuecakpotuzorduakpotuzorjo deritisratioandrelatedparametersamongbreastcancerpatientsinasouthernnigeriapopulation |