α-Actinin-1 deficiency in megakaryocytes causes low platelet count, platelet dysfunction, and mitochondrial impairment

α-Actinin-1 deficiency in megakaryocytes causes low platelet count, platelet dysfunction, and mitochondrial impairment

Abstract: Cytoskeletal remodeling and mitochondrial bioenergetics play important roles in thrombocytopoiesis and platelet function. Recently, α-actinin-1 mutations have been reported in patients with congenital macrothrombocytopenia. However, the role and underlying mechanism of α-actinin-1 in throm...

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Main Authors: Xiangjie Lin, Hanchen Gao, Min Xin, Jian Huang, Xia Li, Yutong Zhou, Keyu Lv, Xin Huang, Jinghan Wang, Yulan Zhou, Dawei Cui, Chao Fang, Lanlan Wu, Xiaofeng Shi, Zhixin Ma, Yu Qian, Hongyan Tong, Jing Dai, Jie Jin, Jiansong Huang
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925000217
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