Exposure to bisphenol A and its analogs provides a preliminary indication of the risk of cognitive impairment for the elderly via an XGboost-based model
Bisphenol A (BPA) and its bisphenol analogs (BPs) serve as key precursors in the manufacturing of polycarbonate plastics and epoxy resins. However, due to BPA’ s detrimental health effects, there has been a growing global consensus to restrict its use. The elderly, being particularly susceptible to...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2025-06-01
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| Series: | Emerging Contaminants |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405665025000083 |
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| author | Yilan Deng Qunlin Xiao Peiyi Liu Yiming Ge Xiaohu Ren Xinjie Li Qinru Xiao Benhong Xu Xiao Chen Jianjun Liu Haiyan Huang Shaoyou Lu |
| author_facet | Yilan Deng Qunlin Xiao Peiyi Liu Yiming Ge Xiaohu Ren Xinjie Li Qinru Xiao Benhong Xu Xiao Chen Jianjun Liu Haiyan Huang Shaoyou Lu |
| author_sort | Yilan Deng |
| collection | DOAJ |
| description | Bisphenol A (BPA) and its bisphenol analogs (BPs) serve as key precursors in the manufacturing of polycarbonate plastics and epoxy resins. However, due to BPA’ s detrimental health effects, there has been a growing global consensus to restrict its use. The elderly, being particularly susceptible to neurodegenerative disorders, represent a population of concern; yet, research exploring the association between BPs exposure and neurodegenerative diseases in the elderly remains scarce. In this study, the urinary levels of six BPs among 267 participants from the Shenzhen aging-related disorder cohort in China during 2017–2018 were measured. Cognitive status was evaluated using the Mini-Mental State Examination (MMSE), and the impact of sociodemographic factors, lifestyle habits, and dietary practices was analyzed through the Extreme Gradient Boosting (XGBoost) classifier. In this study, BPA was the highest urinary level of bisphenol compound detected in the high-risk group (2.10 ng/mL, 95.2 %). Significant differences in BPs levels were observed to the degree of education, tea consumption frequency, meat intake frequency, and distance of main road groups (P < 0.05). Notably, the absence of a significant positive correlation between BPF and BPA levels in high-risk groups for cognitive impairment implies more findings may be needed to fully evaluate BPF’ s actual human exposure levels. The XGBoost models have further revealed that BPA analogs exposure and certain housing characteristics were substantial contributors to the potential impact on cognitive impairment during aging not only BPA. |
| format | Article |
| id | doaj-art-cc5e528504284b0eaa5f2ea659231874 |
| institution | OA Journals |
| issn | 2405-6650 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Emerging Contaminants |
| spelling | doaj-art-cc5e528504284b0eaa5f2ea6592318742025-08-20T02:35:21ZengKeAi Communications Co., Ltd.Emerging Contaminants2405-66502025-06-0111210047410.1016/j.emcon.2025.100474Exposure to bisphenol A and its analogs provides a preliminary indication of the risk of cognitive impairment for the elderly via an XGboost-based modelYilan Deng0Qunlin Xiao1Peiyi Liu2Yiming Ge3Xiaohu Ren4Xinjie Li5Qinru Xiao6Benhong Xu7Xiao Chen8Jianjun Liu9Haiyan Huang10Shaoyou Lu11School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, ChinaThe Eighth Affiliated Hospital, Sun Yat-sen University, 518033, Shenzhen, ChinaShenzhen Center for Disease Control and Prevention, Shenzhen, 518055, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, ChinaShenzhen Center for Disease Control and Prevention, Shenzhen, 518055, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, ChinaSchool of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, ChinaShenzhen Center for Disease Control and Prevention, Shenzhen, 518055, ChinaShenzhen Center for Disease Control and Prevention, Shenzhen, 518055, ChinaShenzhen Center for Disease Control and Prevention, Shenzhen, 518055, ChinaShenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China; Corresponding author.School of Public Health (Shenzhen), Shenzhen Campus of Sun Yat-sen University, Shenzhen, 518107, China; Corresponding author.Bisphenol A (BPA) and its bisphenol analogs (BPs) serve as key precursors in the manufacturing of polycarbonate plastics and epoxy resins. However, due to BPA’ s detrimental health effects, there has been a growing global consensus to restrict its use. The elderly, being particularly susceptible to neurodegenerative disorders, represent a population of concern; yet, research exploring the association between BPs exposure and neurodegenerative diseases in the elderly remains scarce. In this study, the urinary levels of six BPs among 267 participants from the Shenzhen aging-related disorder cohort in China during 2017–2018 were measured. Cognitive status was evaluated using the Mini-Mental State Examination (MMSE), and the impact of sociodemographic factors, lifestyle habits, and dietary practices was analyzed through the Extreme Gradient Boosting (XGBoost) classifier. In this study, BPA was the highest urinary level of bisphenol compound detected in the high-risk group (2.10 ng/mL, 95.2 %). Significant differences in BPs levels were observed to the degree of education, tea consumption frequency, meat intake frequency, and distance of main road groups (P < 0.05). Notably, the absence of a significant positive correlation between BPF and BPA levels in high-risk groups for cognitive impairment implies more findings may be needed to fully evaluate BPF’ s actual human exposure levels. The XGBoost models have further revealed that BPA analogs exposure and certain housing characteristics were substantial contributors to the potential impact on cognitive impairment during aging not only BPA.http://www.sciencedirect.com/science/article/pii/S2405665025000083Endocrine disruptorsHuman exposureAgingUrine samples |
| spellingShingle | Yilan Deng Qunlin Xiao Peiyi Liu Yiming Ge Xiaohu Ren Xinjie Li Qinru Xiao Benhong Xu Xiao Chen Jianjun Liu Haiyan Huang Shaoyou Lu Exposure to bisphenol A and its analogs provides a preliminary indication of the risk of cognitive impairment for the elderly via an XGboost-based model Emerging Contaminants Endocrine disruptors Human exposure Aging Urine samples |
| title | Exposure to bisphenol A and its analogs provides a preliminary indication of the risk of cognitive impairment for the elderly via an XGboost-based model |
| title_full | Exposure to bisphenol A and its analogs provides a preliminary indication of the risk of cognitive impairment for the elderly via an XGboost-based model |
| title_fullStr | Exposure to bisphenol A and its analogs provides a preliminary indication of the risk of cognitive impairment for the elderly via an XGboost-based model |
| title_full_unstemmed | Exposure to bisphenol A and its analogs provides a preliminary indication of the risk of cognitive impairment for the elderly via an XGboost-based model |
| title_short | Exposure to bisphenol A and its analogs provides a preliminary indication of the risk of cognitive impairment for the elderly via an XGboost-based model |
| title_sort | exposure to bisphenol a and its analogs provides a preliminary indication of the risk of cognitive impairment for the elderly via an xgboost based model |
| topic | Endocrine disruptors Human exposure Aging Urine samples |
| url | http://www.sciencedirect.com/science/article/pii/S2405665025000083 |
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