Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment
Abstract We evaluated associations among exposure to prenatal phthalate metabolites, perturbations of the newborn metabolome, and infant neurobehavioral functioning in mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort during 2016–2018. We quantified eight phthalate...
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Nature Portfolio
2025-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-57273-z |
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| author | Susan S. Hoffman Ziyin Tang Anne Dunlop Patricia A. Brennan Thompson Huynh Stephanie M. Eick Dana B. Barr Blake Rushing Susan L. McRitchie Susan Sumner Kaitlin R. Taibl Youran Tan Parinya Panuwet Grace E. Lee Jasmin Eatman Elizabeth J. Corwin P. Barry Ryan Dean P. Jones Donghai Liang |
| author_facet | Susan S. Hoffman Ziyin Tang Anne Dunlop Patricia A. Brennan Thompson Huynh Stephanie M. Eick Dana B. Barr Blake Rushing Susan L. McRitchie Susan Sumner Kaitlin R. Taibl Youran Tan Parinya Panuwet Grace E. Lee Jasmin Eatman Elizabeth J. Corwin P. Barry Ryan Dean P. Jones Donghai Liang |
| author_sort | Susan S. Hoffman |
| collection | DOAJ |
| description | Abstract We evaluated associations among exposure to prenatal phthalate metabolites, perturbations of the newborn metabolome, and infant neurobehavioral functioning in mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort during 2016–2018. We quantified eight phthalate metabolites in prenatal urine samples collected between 8- and 14-weeks’ (visit 1; n = 216) and 24- and 30-weeks’ gestation (visit 2; n = 145) and metabolite features in newborn dried-blood spot samples collected at delivery. Associations between phthalate metabolite concentrations and metabolic feature intensities at both visits were examined using adjusted generalized linear models (MWAS). Then, an exploratory meet-in-the-middle (MITM) analysis was conducted in a subset with NICU Neonatal Neurobehavioral Scale (NNNS) scores (visit 1 n = 81; visit 2 n = 71). In both the MWAS and MITM, many of the confirmed metabolites are involved in tyrosine and tryptophan metabolism, including tryptophan, tyrosine, thyroxine, and serine. This analysis elucidates how prenatal phthalate exposure disrupts the newborn metabolome and infant neurobehavioral outcomes. |
| format | Article |
| id | doaj-art-cc5c5f6a244d4ed3b92660cef1246a07 |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-cc5c5f6a244d4ed3b92660cef1246a072025-08-20T02:08:09ZengNature PortfolioNature Communications2041-17232025-04-0116111610.1038/s41467-025-57273-zImpact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopmentSusan S. Hoffman0Ziyin Tang1Anne Dunlop2Patricia A. Brennan3Thompson Huynh4Stephanie M. Eick5Dana B. Barr6Blake Rushing7Susan L. McRitchie8Susan Sumner9Kaitlin R. Taibl10Youran Tan11Parinya Panuwet12Grace E. Lee13Jasmin Eatman14Elizabeth J. Corwin15P. Barry Ryan16Dean P. Jones17Donghai Liang18Department of Epidemiology, Emory UniversityGangarosa Department of Environmental Health, Emory UniversityDepartment of Gynecology and Obstetrics, School of Medicine, Emory UniversityDepartment of Psychology, Emory UniversityGangarosa Department of Environmental Health, Emory UniversityGangarosa Department of Environmental Health, Emory UniversityGangarosa Department of Environmental Health, Emory UniversityDepartment of Nutrition, University of North Carolina at Chapel HillNutrition Research Institute, University of North Carolina at Chapel HillDepartment of Nutrition, University of North Carolina at Chapel HillGangarosa Department of Environmental Health, Emory UniversityGangarosa Department of Environmental Health, Emory UniversityGangarosa Department of Environmental Health, Emory UniversityGangarosa Department of Environmental Health, Emory UniversityGangarosa Department of Environmental Health, Emory UniversitySchool of Nursing, Columbia UniversityGangarosa Department of Environmental Health, Emory UniversitySchool of Medicine, Emory UniversityDepartment of Epidemiology, Emory UniversityAbstract We evaluated associations among exposure to prenatal phthalate metabolites, perturbations of the newborn metabolome, and infant neurobehavioral functioning in mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort during 2016–2018. We quantified eight phthalate metabolites in prenatal urine samples collected between 8- and 14-weeks’ (visit 1; n = 216) and 24- and 30-weeks’ gestation (visit 2; n = 145) and metabolite features in newborn dried-blood spot samples collected at delivery. Associations between phthalate metabolite concentrations and metabolic feature intensities at both visits were examined using adjusted generalized linear models (MWAS). Then, an exploratory meet-in-the-middle (MITM) analysis was conducted in a subset with NICU Neonatal Neurobehavioral Scale (NNNS) scores (visit 1 n = 81; visit 2 n = 71). In both the MWAS and MITM, many of the confirmed metabolites are involved in tyrosine and tryptophan metabolism, including tryptophan, tyrosine, thyroxine, and serine. This analysis elucidates how prenatal phthalate exposure disrupts the newborn metabolome and infant neurobehavioral outcomes.https://doi.org/10.1038/s41467-025-57273-z |
| spellingShingle | Susan S. Hoffman Ziyin Tang Anne Dunlop Patricia A. Brennan Thompson Huynh Stephanie M. Eick Dana B. Barr Blake Rushing Susan L. McRitchie Susan Sumner Kaitlin R. Taibl Youran Tan Parinya Panuwet Grace E. Lee Jasmin Eatman Elizabeth J. Corwin P. Barry Ryan Dean P. Jones Donghai Liang Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment Nature Communications |
| title | Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment |
| title_full | Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment |
| title_fullStr | Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment |
| title_full_unstemmed | Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment |
| title_short | Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment |
| title_sort | impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment |
| url | https://doi.org/10.1038/s41467-025-57273-z |
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