Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice
Transcranially delivered diagnostic ultrasound (tDUS) applied to the human brain can modulate those brains such that they became more receptive to external stimulation relative to sham ultrasound exposure. Here, we sought to directly measure the effect of tDUS on mouse brain activity subjected to an...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2024.1509432/full |
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| author | Henry Tan Devon J. Griggs Devon J. Griggs Lucas Chen Kahte Adele Culevski Kathryn Floerchinger Alissa Phutirat Gabe Koh Nels Schimek Pierre D. Mourad Pierre D. Mourad |
| author_facet | Henry Tan Devon J. Griggs Devon J. Griggs Lucas Chen Kahte Adele Culevski Kathryn Floerchinger Alissa Phutirat Gabe Koh Nels Schimek Pierre D. Mourad Pierre D. Mourad |
| author_sort | Henry Tan |
| collection | DOAJ |
| description | Transcranially delivered diagnostic ultrasound (tDUS) applied to the human brain can modulate those brains such that they became more receptive to external stimulation relative to sham ultrasound exposure. Here, we sought to directly measure the effect of tDUS on mouse brain activity subjected to an external stimulation—a blinking light. Using electrocorticography, we observed a substantial increase in median brain activity due to tDUS plus a blinking light relative to baseline and relative to sham tDUS plus a blinking light. Subsequent brain activity decreased after cessation of tDUS but with continuation of the blinking light, though it remained above that demonstrated by mice exposed to only a blinking light. In a separate experiment, we showed that tDUS alone, without a blinking light, had no observable effect on median brain activity, but upon its cessation, brain activity decreased. These results demonstrate that simultaneous exposure to tDUS and blinking light can increase the receptivity of the visual cortex of mice exposed to that light, and that prior exposure to tDUS can reduce subsequent brain activity. In each case, these results are consistent with published data. Our results on mice echo published human results but do not directly explain them, since their test subjects received less intense diagnostic ultrasound than did our mice. Given the near ubiquity of diagnostic ultrasound systems, further progress along this line of research could one day lead to the widespread use of diagnostic ultrasound to intentionally modulate human brain function during exogenous stimulation. |
| format | Article |
| id | doaj-art-cc5b77a8da9244eda0ab16c83971e3b8 |
| institution | Kabale University |
| issn | 1662-5161 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj-art-cc5b77a8da9244eda0ab16c83971e3b82025-02-11T07:00:18ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612025-02-011810.3389/fnhum.2024.15094321509432Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of miceHenry Tan0Devon J. Griggs1Devon J. Griggs2Lucas Chen3Kahte Adele Culevski4Kathryn Floerchinger5Alissa Phutirat6Gabe Koh7Nels Schimek8Pierre D. Mourad9Pierre D. Mourad10Department of Neurological Surgery, University of Washington, Seattle, WA, United StatesDepartment of Electrical and Computer Engineering, University of Washington, Seattle, WA, United StatesWashington National Primate Research Center, Seattle, WA, United StatesDepartment of Neurological Surgery, University of Washington, Seattle, WA, United StatesDepartment of Neurological Surgery, University of Washington, Seattle, WA, United StatesDepartment of Neurological Surgery, University of Washington, Seattle, WA, United StatesDepartment of Neurological Surgery, University of Washington, Seattle, WA, United StatesDepartment of Neurological Surgery, University of Washington, Seattle, WA, United StatesDepartment of Neurological Surgery, University of Washington, Seattle, WA, United StatesDepartment of Neurological Surgery, University of Washington, Seattle, WA, United StatesDivision of Engineering and Mathematics, University of Washington, Bothell, WA, United StatesTranscranially delivered diagnostic ultrasound (tDUS) applied to the human brain can modulate those brains such that they became more receptive to external stimulation relative to sham ultrasound exposure. Here, we sought to directly measure the effect of tDUS on mouse brain activity subjected to an external stimulation—a blinking light. Using electrocorticography, we observed a substantial increase in median brain activity due to tDUS plus a blinking light relative to baseline and relative to sham tDUS plus a blinking light. Subsequent brain activity decreased after cessation of tDUS but with continuation of the blinking light, though it remained above that demonstrated by mice exposed to only a blinking light. In a separate experiment, we showed that tDUS alone, without a blinking light, had no observable effect on median brain activity, but upon its cessation, brain activity decreased. These results demonstrate that simultaneous exposure to tDUS and blinking light can increase the receptivity of the visual cortex of mice exposed to that light, and that prior exposure to tDUS can reduce subsequent brain activity. In each case, these results are consistent with published data. Our results on mice echo published human results but do not directly explain them, since their test subjects received less intense diagnostic ultrasound than did our mice. Given the near ubiquity of diagnostic ultrasound systems, further progress along this line of research could one day lead to the widespread use of diagnostic ultrasound to intentionally modulate human brain function during exogenous stimulation.https://www.frontiersin.org/articles/10.3389/fnhum.2024.1509432/fulldiagnostic ultrasoundultrasoundultrasound stimulationfocused ultrasoundvisual stimulationneuromodulation |
| spellingShingle | Henry Tan Devon J. Griggs Devon J. Griggs Lucas Chen Kahte Adele Culevski Kathryn Floerchinger Alissa Phutirat Gabe Koh Nels Schimek Pierre D. Mourad Pierre D. Mourad Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice Frontiers in Human Neuroscience diagnostic ultrasound ultrasound ultrasound stimulation focused ultrasound visual stimulation neuromodulation |
| title | Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice |
| title_full | Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice |
| title_fullStr | Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice |
| title_full_unstemmed | Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice |
| title_short | Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice |
| title_sort | diagnostic ultrasound enhances then reduces exogenously induced brain activity of mice |
| topic | diagnostic ultrasound ultrasound ultrasound stimulation focused ultrasound visual stimulation neuromodulation |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2024.1509432/full |
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