Influence of the modulator and inhibitor of TLR4 on biochemical indexes in a pulp of cutters of rats
In a model experiment reaction of a pulp of cutters of rats to introduction of melatonin and an inhibitor of TLR4 was studied. It is established that introduction of melatonin stimulates activity of AST and LDH in a pulp of cutters of experienced rats. Introduction of an inhibitor of TLR4 activates...
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| Format: | Article |
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| Language: | Russian |
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LLC "Endo Press"
2020-04-01
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| Series: | Эндодонтия Today |
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| Online Access: | https://www.endodont.ru/jour/article/view/261 |
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| description | In a model experiment reaction of a pulp of cutters of rats to introduction of melatonin and an inhibitor of TLR4 was studied. It is established that introduction of melatonin stimulates activity of AST and LDH in a pulp of cutters of experienced rats. Introduction of an inhibitor of TLR4 activates AST to a large extent and suppresses LDH. Activity of ALP in a pulp of cutters of rats in response to melatonin increases in a pulp of the top cutters and goes down in a pulp of the lower cutters. In case of introduction of the antagonist of TLR4, inversely proportional changes in activity of ALP in a pulp of cutters are observed. Shifts in the quantitative composition of IL-6 and TNF-α were more essential at introduction of an inhibitor of TLR4. |
| format | Article |
| id | doaj-art-cc4e8ba850134e34aeb14a30d5752b79 |
| institution | Kabale University |
| issn | 1683-2981 1726-7242 |
| language | Russian |
| publishDate | 2020-04-01 |
| publisher | LLC "Endo Press" |
| record_format | Article |
| series | Эндодонтия Today |
| spelling | doaj-art-cc4e8ba850134e34aeb14a30d5752b792025-08-20T03:35:00ZrusLLC "Endo Press"Эндодонтия Today1683-29811726-72422020-04-01144711248Influence of the modulator and inhibitor of TLR4 on biochemical indexes in a pulp of cutters of rats01234567ФГБОУ ВО Московский государственный медико-стоматологический университет имени А.И. Евдокимова Минздрава РФФГБОУ ВО Московский государственный медико-стоматологический университет имени А.И. Евдокимова Минздрава РФ; ФГБНУ «НИИ нормальной физиологии имени П.К. Анохина»ФГБОУ ВО Московский государственный медико-стоматологический университет имени А.И. Евдокимова Минздрава РФ; ФГБНУ «НИИ нормальной физиологии имени П.К. Анохина»ФГБОУ ВО Московский государственный медико-стоматологический университет имени А.И. Евдокимова Минздрава РФФГБОУ ВО Московский государственный медико-стоматологический университет имени А.И. Евдокимова Минздрава РФФГБОУ ВО Московский государственный медико-стоматологический университет имени А.И. Евдокимова Минздрава РФФГБОУ ВО Московский государственный медико-стоматологический университет имени А.И. Евдокимова Минздрава РФФГБОУ ВО Московский государственный медико-стоматологический университет имени А.И. Евдокимова Минздрава РФIn a model experiment reaction of a pulp of cutters of rats to introduction of melatonin and an inhibitor of TLR4 was studied. It is established that introduction of melatonin stimulates activity of AST and LDH in a pulp of cutters of experienced rats. Introduction of an inhibitor of TLR4 activates AST to a large extent and suppresses LDH. Activity of ALP in a pulp of cutters of rats in response to melatonin increases in a pulp of the top cutters and goes down in a pulp of the lower cutters. In case of introduction of the antagonist of TLR4, inversely proportional changes in activity of ALP in a pulp of cutters are observed. Shifts in the quantitative composition of IL-6 and TNF-α were more essential at introduction of an inhibitor of TLR4.https://www.endodont.ru/jour/article/view/261пульпа зубамелатонинингибитор tlr4ферментыцитокиныtooth pulpmelatonininhibitor tlr4enzymescytokines |
| spellingShingle | Influence of the modulator and inhibitor of TLR4 on biochemical indexes in a pulp of cutters of rats Эндодонтия Today пульпа зуба мелатонин ингибитор tlr4 ферменты цитокины tooth pulp melatonin inhibitor tlr4 enzymes cytokines |
| title | Influence of the modulator and inhibitor of TLR4 on biochemical indexes in a pulp of cutters of rats |
| title_full | Influence of the modulator and inhibitor of TLR4 on biochemical indexes in a pulp of cutters of rats |
| title_fullStr | Influence of the modulator and inhibitor of TLR4 on biochemical indexes in a pulp of cutters of rats |
| title_full_unstemmed | Influence of the modulator and inhibitor of TLR4 on biochemical indexes in a pulp of cutters of rats |
| title_short | Influence of the modulator and inhibitor of TLR4 on biochemical indexes in a pulp of cutters of rats |
| title_sort | influence of the modulator and inhibitor of tlr4 on biochemical indexes in a pulp of cutters of rats |
| topic | пульпа зуба мелатонин ингибитор tlr4 ферменты цитокины tooth pulp melatonin inhibitor tlr4 enzymes cytokines |
| url | https://www.endodont.ru/jour/article/view/261 |