Insights into the Transmission, Host Range, Genomics, Vaccination, and Current Epidemiology of the Monkeypox Virus
This review delves into the historical context, current epidemiological landscape, genomics, and pathobiology of monkeypox virus (MPXV). Furthermore, it elucidates the present vaccination status and strategies to curb the spread of monkeypox. Monkeypox, caused by the Orthopoxvirus known as MPXV, is...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Veterinary Medicine International |
| Online Access: | http://dx.doi.org/10.1155/2024/8839830 |
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| author | Yusha Araf Jannatul Ferdous Nipa Sabekun Naher Sumaiya Tasnim Maliha Hasanur Rahman Kazi Ifthi Arafat Mohammad Raguib Munif Md Jamal Uddin Nurejunnati Jeba Sukumar Saha Jingbo Zhai S. M. Nazmul Hasan Mengzhou Xue Md. Golzar Hossain Chunfu Zheng |
| author_facet | Yusha Araf Jannatul Ferdous Nipa Sabekun Naher Sumaiya Tasnim Maliha Hasanur Rahman Kazi Ifthi Arafat Mohammad Raguib Munif Md Jamal Uddin Nurejunnati Jeba Sukumar Saha Jingbo Zhai S. M. Nazmul Hasan Mengzhou Xue Md. Golzar Hossain Chunfu Zheng |
| author_sort | Yusha Araf |
| collection | DOAJ |
| description | This review delves into the historical context, current epidemiological landscape, genomics, and pathobiology of monkeypox virus (MPXV). Furthermore, it elucidates the present vaccination status and strategies to curb the spread of monkeypox. Monkeypox, caused by the Orthopoxvirus known as MPXV, is a zoonotic ailment. MPXV can be transmitted from person to person through respiratory droplets during prolonged face-to-face interactions. While many cases of monkeypox are self-limiting, vulnerable groups such as young children, pregnant women, and immunocompromised individuals may experience severe manifestations. Diagnosis predominantly relies on clinical presentations, complemented by laboratory techniques like RT-PCR. Although treatment is often not required, severe cases necessitate antiviral medications like tecovirimat, cidofovir, and brincidofovir. Vaccination, particularly using the smallpox vaccine, has proven instrumental in outbreak control, exhibiting an efficacy of at least 85% against mpox as evidenced by data from Africa. Mitigating transmission requires measures like wearing surgical masks, adequately covering skin lesions, and avoiding handling wild animals. |
| format | Article |
| id | doaj-art-cc49dcdfe4d6422aa241e38e1ea39747 |
| institution | Kabale University |
| issn | 2042-0048 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine International |
| spelling | doaj-art-cc49dcdfe4d6422aa241e38e1ea397472025-02-03T07:23:37ZengWileyVeterinary Medicine International2042-00482024-01-01202410.1155/2024/8839830Insights into the Transmission, Host Range, Genomics, Vaccination, and Current Epidemiology of the Monkeypox VirusYusha Araf0Jannatul Ferdous Nipa1Sabekun Naher2Sumaiya Tasnim Maliha3Hasanur Rahman4Kazi Ifthi Arafat5Mohammad Raguib Munif6Md Jamal Uddin7Nurejunnati Jeba8Sukumar Saha9Jingbo Zhai10S. M. Nazmul Hasan11Mengzhou Xue12Md. Golzar Hossain13Chunfu Zheng14Guangzhou Eighth People’s HospitalDepartment of Genetic Engineering and BiotechnologyDepartment of MicrobiologyBiotechnology ProgramDepartment of Biotechnology and Genetic EngineeringDepartment of Biotechnology and Genetic EngineeringDepartment of Surgery and ObstetricsABEx Bio-Research CenterDepartment of Microbiology and HygieneDepartment of Microbiology and HygieneKey Laboratory of Zoonose Prevention and Control at Universities of Inner Mongolia Autonomous RegionDepartment of Microbiology and HygieneDepartment of Cerebrovascular DiseasesDepartment of Microbiology and HygieneGuangzhou Eighth People’s HospitalThis review delves into the historical context, current epidemiological landscape, genomics, and pathobiology of monkeypox virus (MPXV). Furthermore, it elucidates the present vaccination status and strategies to curb the spread of monkeypox. Monkeypox, caused by the Orthopoxvirus known as MPXV, is a zoonotic ailment. MPXV can be transmitted from person to person through respiratory droplets during prolonged face-to-face interactions. While many cases of monkeypox are self-limiting, vulnerable groups such as young children, pregnant women, and immunocompromised individuals may experience severe manifestations. Diagnosis predominantly relies on clinical presentations, complemented by laboratory techniques like RT-PCR. Although treatment is often not required, severe cases necessitate antiviral medications like tecovirimat, cidofovir, and brincidofovir. Vaccination, particularly using the smallpox vaccine, has proven instrumental in outbreak control, exhibiting an efficacy of at least 85% against mpox as evidenced by data from Africa. Mitigating transmission requires measures like wearing surgical masks, adequately covering skin lesions, and avoiding handling wild animals.http://dx.doi.org/10.1155/2024/8839830 |
| spellingShingle | Yusha Araf Jannatul Ferdous Nipa Sabekun Naher Sumaiya Tasnim Maliha Hasanur Rahman Kazi Ifthi Arafat Mohammad Raguib Munif Md Jamal Uddin Nurejunnati Jeba Sukumar Saha Jingbo Zhai S. M. Nazmul Hasan Mengzhou Xue Md. Golzar Hossain Chunfu Zheng Insights into the Transmission, Host Range, Genomics, Vaccination, and Current Epidemiology of the Monkeypox Virus Veterinary Medicine International |
| title | Insights into the Transmission, Host Range, Genomics, Vaccination, and Current Epidemiology of the Monkeypox Virus |
| title_full | Insights into the Transmission, Host Range, Genomics, Vaccination, and Current Epidemiology of the Monkeypox Virus |
| title_fullStr | Insights into the Transmission, Host Range, Genomics, Vaccination, and Current Epidemiology of the Monkeypox Virus |
| title_full_unstemmed | Insights into the Transmission, Host Range, Genomics, Vaccination, and Current Epidemiology of the Monkeypox Virus |
| title_short | Insights into the Transmission, Host Range, Genomics, Vaccination, and Current Epidemiology of the Monkeypox Virus |
| title_sort | insights into the transmission host range genomics vaccination and current epidemiology of the monkeypox virus |
| url | http://dx.doi.org/10.1155/2024/8839830 |
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