Lomitapide modifies high-density lipoprotein function in homozygous familial hypercholesterolaemia

Lomitapide modifies high-density lipoprotein function in homozygous familial hypercholesterolaemia

Abstract Background Lomitapide reduces plasma low-density lipoprotein cholesterol (LDL-C) and is approved for the treatment of homozygous familial hypercholesterolemia (HoFH). This study aims to determine the effect of lomitapide on HDL and cholesterol efflux in a cohort of patients with HoFH. Patie...

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Bibliographic Details
Main Authors: Anouar Hafiane, Annalisa Ronca, Matteo Incerti, Alessandra Rossi, Matteo Manfredini, Elda Favari
Format: Article
Language:English
Published: BMC 2025-04-01
Series:European Journal of Medical Research
Subjects:
Apo B
Cholesterol efflux capacity
HDL cholesterol
Homozygous familial hypercholesterolaemia
Lomitapide
LDL cholesterol
Online Access:https://doi.org/10.1186/s40001-025-02439-0
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