Helicobacter pylori Infection in Dialysis Patients: A Meta-Analysis
Background. Infection with Helicobacter pylori contributes to the etiopathogenesis of various extragastrointestinal conditions, yet its etiological association with either symptomatic or asymptomatic dialysis patients remains inconclusive. Methods. Two researchers working independently conducted a l...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/785892 |
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| author | Min Gu Shuping Xiao Xiaolin Pan Guoxin Zhang |
| author_facet | Min Gu Shuping Xiao Xiaolin Pan Guoxin Zhang |
| author_sort | Min Gu |
| collection | DOAJ |
| description | Background. Infection with Helicobacter pylori contributes to the etiopathogenesis of various extragastrointestinal conditions, yet its etiological association with either symptomatic or asymptomatic dialysis patients remains inconclusive. Methods. Two researchers working independently conducted a literature search of the online databases PubMed, EMBase, ScienceDirect, and Cochrane Central Register of Controlled Trials to identify relevant articles to the end of 2012. Case-control and cross-sectional studies that met the inclusion criteria were included. Results. Fifteen studies involving 1237 dialysis patients and 1568 controls with normal renal function were included. Compared with normal controls, dialysis patients overall were associated with a relatively lower risk of H. pylori infection though not statistically significant. A significant inverse association was found between H. pylori prevalence and duration of treatments in those who were dialyzed >4 years (odds ratio 0.28; 95% confidence interval 0.22–0.36, ). No relationship between H. pylori status and duration of dialysis was observed in CRF patients. There were no significant differences in endoscopic features between patients and controls. Conclusions. Our meta-analysis found no evidence of a significant association between infection with H. pylori and dialysis overall, whereas long-term treatments of more than four years had a significant protective effect. |
| format | Article |
| id | doaj-art-cc461203e0644d43b3fae429003c899d |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-cc461203e0644d43b3fae429003c899d2025-02-03T06:44:30ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/785892785892Helicobacter pylori Infection in Dialysis Patients: A Meta-AnalysisMin Gu0Shuping Xiao1Xiaolin Pan2Guoxin Zhang3Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaBackground. Infection with Helicobacter pylori contributes to the etiopathogenesis of various extragastrointestinal conditions, yet its etiological association with either symptomatic or asymptomatic dialysis patients remains inconclusive. Methods. Two researchers working independently conducted a literature search of the online databases PubMed, EMBase, ScienceDirect, and Cochrane Central Register of Controlled Trials to identify relevant articles to the end of 2012. Case-control and cross-sectional studies that met the inclusion criteria were included. Results. Fifteen studies involving 1237 dialysis patients and 1568 controls with normal renal function were included. Compared with normal controls, dialysis patients overall were associated with a relatively lower risk of H. pylori infection though not statistically significant. A significant inverse association was found between H. pylori prevalence and duration of treatments in those who were dialyzed >4 years (odds ratio 0.28; 95% confidence interval 0.22–0.36, ). No relationship between H. pylori status and duration of dialysis was observed in CRF patients. There were no significant differences in endoscopic features between patients and controls. Conclusions. Our meta-analysis found no evidence of a significant association between infection with H. pylori and dialysis overall, whereas long-term treatments of more than four years had a significant protective effect.http://dx.doi.org/10.1155/2013/785892 |
| spellingShingle | Min Gu Shuping Xiao Xiaolin Pan Guoxin Zhang Helicobacter pylori Infection in Dialysis Patients: A Meta-Analysis Gastroenterology Research and Practice |
| title | Helicobacter pylori Infection in Dialysis Patients: A Meta-Analysis |
| title_full | Helicobacter pylori Infection in Dialysis Patients: A Meta-Analysis |
| title_fullStr | Helicobacter pylori Infection in Dialysis Patients: A Meta-Analysis |
| title_full_unstemmed | Helicobacter pylori Infection in Dialysis Patients: A Meta-Analysis |
| title_short | Helicobacter pylori Infection in Dialysis Patients: A Meta-Analysis |
| title_sort | helicobacter pylori infection in dialysis patients a meta analysis |
| url | http://dx.doi.org/10.1155/2013/785892 |
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