EBI2-oxysterol signalling regulates VE-cadherin expression and multiple sclerosis CD4+ T cell attachment to a human tri-cell spheroid blood-brain barrier model

EBI2-oxysterol signalling regulates VE-cadherin expression and multiple sclerosis CD4+ T cell attachment to a human tri-cell spheroid blood-brain barrier model

Changes in the function of the blood-brain barrier (BBB) are one of the hallmarks of multiple sclerosis (MS) and are observed at very early stages of the disease. Several disease-modifying therapies for MS regulate tight junction and adherence junction proteins in the BBB thus limiting the entry of...

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Bibliographic Details
Main Authors: Fionä Caratis, Inez Mruk, Klaudia Konieczna-Wolska, Bartłomiej Rojek, Marek Hałas, Paulina Czaplewska, Bartosz Karaszewski, Tomomi Furihata, Aleksandra Rutkowska
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Multiple sclerosis
Neuroinflammation
Oxysterols
EBI2
Blood-brain barrier
Cerebrospinal fluid
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354625001036
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