Comprehensive Review on Application Progress of Marine Collagen Cross-Linking Modification in Bone Repairs

Bone tissue injuries are a significant health risk, and their repair is challenging. While various materials have potential for bone repair, issues like sourcing and immune rejection limit their use. Marine-derived collagen, abundant and free from religious and disease transmission concerns, is a pr...

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Bibliographic Details
Main Authors: Xiaofei Zhai, Xinrong Geng, Wenjun Li, Hongli Cui, Yunqing Wang, Song Qin
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Marine Drugs
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Online Access:https://www.mdpi.com/1660-3397/23/4/151
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Summary:Bone tissue injuries are a significant health risk, and their repair is challenging. While various materials have potential for bone repair, issues like sourcing and immune rejection limit their use. Marine-derived collagen, abundant and free from religious and disease transmission concerns, is a promising biomaterial in bone tissue engineering. Cross-linking modification can enhance its mechanical properties and degradation rate, making it more suitable for bone repair. However, detailed analysis of cross-linking methods, property changes post-cross-linking, and their impact on bone repair is needed. This review examines marine collagen’s modification methods, improved characteristics, and potential in bone tissue repair, providing a foundation for its effective use in bone tissue engineering.
ISSN:1660-3397