The Role of the Exposome in Aging and Age-Related Diseases: A Comprehensive Review
Aging is a very complex process, which is genetically and environmentally driven. Aging and age-related disease onset are strongly dependent on the exposome (all environmental exposures from conception to death). This review focuses on how environmental load accumulated throughout life, possibly thr...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_599_25 |
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| author | Mohammad A. Kareem Aher Ashwini Thitame Sunil |
| author_facet | Mohammad A. Kareem Aher Ashwini Thitame Sunil |
| author_sort | Mohammad A. Kareem |
| collection | DOAJ |
| description | Aging is a very complex process, which is genetically and environmentally driven. Aging and age-related disease onset are strongly dependent on the exposome (all environmental exposures from conception to death). This review focuses on how environmental load accumulated throughout life, possibly through oxidative stress, inflammation, and epigenetic modulation, influence aging. Specific environmental contributors to neurodegenerative diseases like Alzheimer’s and Parkinson’s and how they have biological impact are explored by us. We also review recent advances performed in exposome research focusing on biomonitoring and multiomics approaches, which allow for novel discovery of the mechanisms for aging related to exposome. We also suggest potential preventive actions that will help to offset the environmental risks and achieve healthy aging. Knowing how the environment plays a role in aging gives the opportunity to develop better strategies to prevent and manage diseases related to age. |
| format | Article |
| id | doaj-art-cc3c4c23be914596b6d38481d7018a4b |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-cc3c4c23be914596b6d38481d7018a4b2025-08-20T03:24:40ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-05-0117Suppl 1S2S510.4103/jpbs.jpbs_599_25The Role of the Exposome in Aging and Age-Related Diseases: A Comprehensive ReviewMohammad A. KareemAher AshwiniThitame SunilAging is a very complex process, which is genetically and environmentally driven. Aging and age-related disease onset are strongly dependent on the exposome (all environmental exposures from conception to death). This review focuses on how environmental load accumulated throughout life, possibly through oxidative stress, inflammation, and epigenetic modulation, influence aging. Specific environmental contributors to neurodegenerative diseases like Alzheimer’s and Parkinson’s and how they have biological impact are explored by us. We also review recent advances performed in exposome research focusing on biomonitoring and multiomics approaches, which allow for novel discovery of the mechanisms for aging related to exposome. We also suggest potential preventive actions that will help to offset the environmental risks and achieve healthy aging. Knowing how the environment plays a role in aging gives the opportunity to develop better strategies to prevent and manage diseases related to age.https://journals.lww.com/10.4103/jpbs.jpbs_599_25age-related diseasesagingexposomeneurodegenerative disorders |
| spellingShingle | Mohammad A. Kareem Aher Ashwini Thitame Sunil The Role of the Exposome in Aging and Age-Related Diseases: A Comprehensive Review Journal of Pharmacy and Bioallied Sciences age-related diseases aging exposome neurodegenerative disorders |
| title | The Role of the Exposome in Aging and Age-Related Diseases: A Comprehensive Review |
| title_full | The Role of the Exposome in Aging and Age-Related Diseases: A Comprehensive Review |
| title_fullStr | The Role of the Exposome in Aging and Age-Related Diseases: A Comprehensive Review |
| title_full_unstemmed | The Role of the Exposome in Aging and Age-Related Diseases: A Comprehensive Review |
| title_short | The Role of the Exposome in Aging and Age-Related Diseases: A Comprehensive Review |
| title_sort | role of the exposome in aging and age related diseases a comprehensive review |
| topic | age-related diseases aging exposome neurodegenerative disorders |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_599_25 |
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