Formulation and evaluation of diclofenac emulgel using natural permeation enhancers
Background: This study aimed to formulate a stable diclofenac emulgel and determine the penetration rate using different natural penetration enhancers. Methodology: Carbopol (934) and Hydroxypropyl methyl cellulose (HPMC) were utilized as gelling agents due to their favorable viscosity characteristi...
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Creative Pharma Assent
2025-04-01
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| Series: | Journal of Applied Pharmaceutical Research |
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| Online Access: | https://japtronline.com/index.php/joapr/article/view/907 |
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| author | Chandra Sekhar Naik D Shaik Noor Mahammed Mudigedu Samreen S. Vamsi P. Hemalatha |
| author_facet | Chandra Sekhar Naik D Shaik Noor Mahammed Mudigedu Samreen S. Vamsi P. Hemalatha |
| author_sort | Chandra Sekhar Naik D |
| collection | DOAJ |
| description | Background: This study aimed to formulate a stable diclofenac emulgel and determine the penetration rate using different natural penetration enhancers. Methodology: Carbopol (934) and Hydroxypropyl methyl cellulose (HPMC) were utilized as gelling agents due to their favorable viscosity characteristics, which render them widely used for regulating the flow properties of topically administered dosage forms. In the research, diclofenac served as the active ingredient, while Carbopol (934) & HPMC (0.5%) acted as gelling forms to form a proper gel base. Emulsion contains Tween-20 (0.05%), PEG (0.6%), liquid paraffin (0.75%), span-20 (0.1%), along with natural penetration enhancers (0.3%) initially prepared gel base & the emulsion with natural penetration enhancers combine conjointly to shape an appropriate diclofenac emulgel. Results and discussion: According to the study, the improved batch exhibits a 95.08% release in 48 hours and remains stable for about three. The optimized batch exhibits 46.6% suppression in the microbiological assay, whereas the marketed treatment only demonstrates 32.3% inhibition. However, the skin irritation test results have no erythema or edema. The rabbits' skin showed no signs of discomfort. According to stability experiments, the synthesized emulgel's antifungal activity, rheological analysis, in vitro drug release, and physical appearance did not alter after three months of storage. Conclusion: Overall, it was recommended that, in contrast to cream, the emulgel formulation come after the drug release for controlled, long-term drug delivery. |
| format | Article |
| id | doaj-art-cc38d4aa54294b989bbac01ceb8fbd12 |
| institution | OA Journals |
| issn | 2348-0335 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Creative Pharma Assent |
| record_format | Article |
| series | Journal of Applied Pharmaceutical Research |
| spelling | doaj-art-cc38d4aa54294b989bbac01ceb8fbd122025-08-20T01:50:18ZengCreative Pharma AssentJournal of Applied Pharmaceutical Research2348-03352025-04-0113210811410.69857/joapr.v13i2.907908Formulation and evaluation of diclofenac emulgel using natural permeation enhancersChandra Sekhar Naik D0Shaik Noor Mahammed1Mudigedu Samreen2S. Vamsi3P. Hemalatha4Department of Pharmaceutics, Nimra College of Pharmacy, Ibrahimpatnam, Vijayawada, Andhra Pradesh, IndiaDepartment of Pharmaceutics, Nimra College of Pharmacy, Ibrahimpatnam, Vijayawada, Andhra Pradesh, IndiaDepartment of Pharmaceutics, Nimra College of Pharmacy, Ibrahimpatnam, Vijayawada, Andhra Pradesh, IndiaDepartment of Pharmaceutics, Nimra College of Pharmacy, Ibrahimpatnam, Vijayawada, Andhra Pradesh, IndiaDepartment of Pharmaceutics, Nimra College of Pharmacy, Ibrahimpatnam, Vijayawada, Andhra Pradesh, IndiaBackground: This study aimed to formulate a stable diclofenac emulgel and determine the penetration rate using different natural penetration enhancers. Methodology: Carbopol (934) and Hydroxypropyl methyl cellulose (HPMC) were utilized as gelling agents due to their favorable viscosity characteristics, which render them widely used for regulating the flow properties of topically administered dosage forms. In the research, diclofenac served as the active ingredient, while Carbopol (934) & HPMC (0.5%) acted as gelling forms to form a proper gel base. Emulsion contains Tween-20 (0.05%), PEG (0.6%), liquid paraffin (0.75%), span-20 (0.1%), along with natural penetration enhancers (0.3%) initially prepared gel base & the emulsion with natural penetration enhancers combine conjointly to shape an appropriate diclofenac emulgel. Results and discussion: According to the study, the improved batch exhibits a 95.08% release in 48 hours and remains stable for about three. The optimized batch exhibits 46.6% suppression in the microbiological assay, whereas the marketed treatment only demonstrates 32.3% inhibition. However, the skin irritation test results have no erythema or edema. The rabbits' skin showed no signs of discomfort. According to stability experiments, the synthesized emulgel's antifungal activity, rheological analysis, in vitro drug release, and physical appearance did not alter after three months of storage. Conclusion: Overall, it was recommended that, in contrast to cream, the emulgel formulation come after the drug release for controlled, long-term drug delivery.https://japtronline.com/index.php/joapr/article/view/907emulgeldiclofenacfactorial designcounter plots3d surface plots |
| spellingShingle | Chandra Sekhar Naik D Shaik Noor Mahammed Mudigedu Samreen S. Vamsi P. Hemalatha Formulation and evaluation of diclofenac emulgel using natural permeation enhancers Journal of Applied Pharmaceutical Research emulgel diclofenac factorial design counter plots 3d surface plots |
| title | Formulation and evaluation of diclofenac emulgel using natural permeation enhancers |
| title_full | Formulation and evaluation of diclofenac emulgel using natural permeation enhancers |
| title_fullStr | Formulation and evaluation of diclofenac emulgel using natural permeation enhancers |
| title_full_unstemmed | Formulation and evaluation of diclofenac emulgel using natural permeation enhancers |
| title_short | Formulation and evaluation of diclofenac emulgel using natural permeation enhancers |
| title_sort | formulation and evaluation of diclofenac emulgel using natural permeation enhancers |
| topic | emulgel diclofenac factorial design counter plots 3d surface plots |
| url | https://japtronline.com/index.php/joapr/article/view/907 |
| work_keys_str_mv | AT chandrasekharnaikd formulationandevaluationofdiclofenacemulgelusingnaturalpermeationenhancers AT shaiknoormahammed formulationandevaluationofdiclofenacemulgelusingnaturalpermeationenhancers AT mudigedusamreen formulationandevaluationofdiclofenacemulgelusingnaturalpermeationenhancers AT svamsi formulationandevaluationofdiclofenacemulgelusingnaturalpermeationenhancers AT phemalatha formulationandevaluationofdiclofenacemulgelusingnaturalpermeationenhancers |