Prognostic factors of triple-negative inflammatory breast cancer based on SEER database
"Objective To investigate the clinicopathological features and survival prognostic factors of patients with triple-negative inflammatory breast cancer (TNIBC). Methods The data of patients with TNIBC from 2010 to 2015 were obtained from SEER database, and univariate analysis, multivariate ana...
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The Editorial Department of Chinese Journal of Clinical Research
2024-10-01
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| Series: | Zhongguo linchuang yanjiu |
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| Online Access: | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241006 |
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| author | CHEN Shuyu, GAO Ya |
| author_facet | CHEN Shuyu, GAO Ya |
| author_sort | CHEN Shuyu, GAO Ya |
| collection | DOAJ |
| description | "Objective To investigate the clinicopathological features and survival prognostic factors of patients with triple-negative inflammatory breast cancer (TNIBC).
Methods The data of patients with TNIBC from 2010 to 2015 were obtained from SEER database, and univariate analysis, multivariate analysis and Kaplan-Meier survival analysis were performed using the “survival” package in R statistical software.
Results A total of 4 268 cases of inflammatory breast cancer were collected, including 1 023 cases of triple-negative subtype. Compared with non-TNIBC patients,TNIBC patients had a lower proportion of whites in ethnic distribution, a higher proportion of histological grade Ⅲ, a higher proportion of AJCC stage Ⅲ, and more patients without distant metastases, and more likely to receive chemotherapy (P＜0.05). Univariate Cox analysis showed that laterality, tumor diameter, AJCC stage, M stage, surgery and chemotherapy may be the influencing factors of overall survival (OS) (P＜0.05). Multivariate Cox analysis showed that laterality, tumor diameter and surgery were independent risk factors for OS in TNIBC patients, and the smaller the tumor (28-989 mm, HR=1.565, 95%CI: 1.061-2.309, P=0.024; ＞989 mm, HR=1.911, 95%CI: 1.205-3.030, P=0.006), locating in the right side (HR=0.719, 95%CI: 0.560-0.923, P=0.010), and the surgical treatment (HR=0.609, 95%CI: 0.423-0.876, P=0.008) were associated with better prognosis.
Conclusion Laterality, tumor diameter, and surgery are independent influencing factors for survival prognosis in patients with TNIBC, and the smaller the tumor, locating in the right side, and surgery are associated with better prognosis."
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| format | Article |
| id | doaj-art-cc34fbe0d73d4135929969195959ed3e |
| institution | OA Journals |
| issn | 1674-8182 |
| language | zho |
| publishDate | 2024-10-01 |
| publisher | The Editorial Department of Chinese Journal of Clinical Research |
| record_format | Article |
| series | Zhongguo linchuang yanjiu |
| spelling | doaj-art-cc34fbe0d73d4135929969195959ed3e2025-08-20T02:08:43ZzhoThe Editorial Department of Chinese Journal of Clinical ResearchZhongguo linchuang yanjiu1674-81822024-10-0137101506151010.13429/j.cnki.cjcr.2024.10.006Prognostic factors of triple-negative inflammatory breast cancer based on SEER databaseCHEN Shuyu, GAO Ya0Department of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China"Objective To investigate the clinicopathological features and survival prognostic factors of patients with triple-negative inflammatory breast cancer (TNIBC). Methods The data of patients with TNIBC from 2010 to 2015 were obtained from SEER database, and univariate analysis, multivariate analysis and Kaplan-Meier survival analysis were performed using the “survival” package in R statistical software. Results A total of 4 268 cases of inflammatory breast cancer were collected, including 1 023 cases of triple-negative subtype. Compared with non-TNIBC patients,TNIBC patients had a lower proportion of whites in ethnic distribution, a higher proportion of histological grade Ⅲ, a higher proportion of AJCC stage Ⅲ, and more patients without distant metastases, and more likely to receive chemotherapy (P＜0.05). Univariate Cox analysis showed that laterality, tumor diameter, AJCC stage, M stage, surgery and chemotherapy may be the influencing factors of overall survival (OS) (P＜0.05). Multivariate Cox analysis showed that laterality, tumor diameter and surgery were independent risk factors for OS in TNIBC patients, and the smaller the tumor (28-989 mm, HR=1.565, 95%CI: 1.061-2.309, P=0.024; ＞989 mm, HR=1.911, 95%CI: 1.205-3.030, P=0.006), locating in the right side (HR=0.719, 95%CI: 0.560-0.923, P=0.010), and the surgical treatment (HR=0.609, 95%CI: 0.423-0.876, P=0.008) were associated with better prognosis. Conclusion Laterality, tumor diameter, and surgery are independent influencing factors for survival prognosis in patients with TNIBC, and the smaller the tumor, locating in the right side, and surgery are associated with better prognosis." http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241006inflammatory breast cancer; triple-negative breast cancer; seer database; prognostic factor; laterality; tumor diameter; surgery |
| spellingShingle | CHEN Shuyu, GAO Ya Prognostic factors of triple-negative inflammatory breast cancer based on SEER database Zhongguo linchuang yanjiu inflammatory breast cancer; triple-negative breast cancer; seer database; prognostic factor; laterality; tumor diameter; surgery |
| title | Prognostic factors of triple-negative inflammatory breast cancer based on SEER database |
| title_full | Prognostic factors of triple-negative inflammatory breast cancer based on SEER database |
| title_fullStr | Prognostic factors of triple-negative inflammatory breast cancer based on SEER database |
| title_full_unstemmed | Prognostic factors of triple-negative inflammatory breast cancer based on SEER database |
| title_short | Prognostic factors of triple-negative inflammatory breast cancer based on SEER database |
| title_sort | prognostic factors of triple negative inflammatory breast cancer based on seer database |
| topic | inflammatory breast cancer; triple-negative breast cancer; seer database; prognostic factor; laterality; tumor diameter; surgery |
| url | http://zglcyj.ijournals.cn/zglcyj/ch/reader/create_pdf.aspx?file_no=20241006 |
| work_keys_str_mv | AT chenshuyugaoya prognosticfactorsoftriplenegativeinflammatorybreastcancerbasedonseerdatabase |