Antioxidant Impact on Specific Antiviral Activity of Human Recombinant Interferon α-2b with Respect to Herpes simplex in Cell Culture
In vitro synergistic antiviral effect of interferon α-2b in combination with unithiol (an antioxidant) on diverse variants of Herpes simplex, including the clinical acyclovir-resistant isolates, was demonstrated. Unithiol showed immediate antiherpes activity in the cell culture. However, its activit...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/318 |
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| author | A. N. Vasilyev |
| author_facet | A. N. Vasilyev |
| author_sort | A. N. Vasilyev |
| collection | DOAJ |
| description | In vitro synergistic antiviral effect of interferon α-2b in combination with unithiol (an antioxidant) on diverse variants of Herpes simplex, including the clinical acyclovir-resistant isolates, was demonstrated. Unithiol showed immediate antiherpes activity in the cell culture. However, its activity was lower than that of ascorbic acid, another highly active antioxidant. It was also observed that the specific antiherpes activity of interferon α-2b in the presence of unithiol increased several times. The data could be useful in the clinical practice, since the drugs combinations or complex formulations provide higher efficacy of the herpetic infection therapy with the use of the same concentrations of the available agents. |
| format | Article |
| id | doaj-art-cc2846c8655b43d99fb5567cf9fe932f |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-cc2846c8655b43d99fb5567cf9fe932f2025-08-20T03:42:01ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01557-8317Antioxidant Impact on Specific Antiviral Activity of Human Recombinant Interferon α-2b with Respect to Herpes simplex in Cell CultureA. N. Vasilyev0Institute of Preclinical and Clinical Examination of Drugs, Scientific Centre for Examination of Medicinal ProductsIn vitro synergistic antiviral effect of interferon α-2b in combination with unithiol (an antioxidant) on diverse variants of Herpes simplex, including the clinical acyclovir-resistant isolates, was demonstrated. Unithiol showed immediate antiherpes activity in the cell culture. However, its activity was lower than that of ascorbic acid, another highly active antioxidant. It was also observed that the specific antiherpes activity of interferon α-2b in the presence of unithiol increased several times. The data could be useful in the clinical practice, since the drugs combinations or complex formulations provide higher efficacy of the herpetic infection therapy with the use of the same concentrations of the available agents.https://www.antibiotics-chemotherapy.ru/jour/article/view/318herpes simplexcell cultureinterferon α-2bunithiol (antioxidant) |
| spellingShingle | A. N. Vasilyev Antioxidant Impact on Specific Antiviral Activity of Human Recombinant Interferon α-2b with Respect to Herpes simplex in Cell Culture Антибиотики и Химиотерапия herpes simplex cell culture interferon α-2b unithiol (antioxidant) |
| title | Antioxidant Impact on Specific Antiviral Activity of Human Recombinant Interferon α-2b with Respect to Herpes simplex in Cell Culture |
| title_full | Antioxidant Impact on Specific Antiviral Activity of Human Recombinant Interferon α-2b with Respect to Herpes simplex in Cell Culture |
| title_fullStr | Antioxidant Impact on Specific Antiviral Activity of Human Recombinant Interferon α-2b with Respect to Herpes simplex in Cell Culture |
| title_full_unstemmed | Antioxidant Impact on Specific Antiviral Activity of Human Recombinant Interferon α-2b with Respect to Herpes simplex in Cell Culture |
| title_short | Antioxidant Impact on Specific Antiviral Activity of Human Recombinant Interferon α-2b with Respect to Herpes simplex in Cell Culture |
| title_sort | antioxidant impact on specific antiviral activity of human recombinant interferon α 2b with respect to herpes simplex in cell culture |
| topic | herpes simplex cell culture interferon α-2b unithiol (antioxidant) |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/318 |
| work_keys_str_mv | AT anvasilyev antioxidantimpactonspecificantiviralactivityofhumanrecombinantinterferona2bwithrespecttoherpessimplexincellculture |