Oxidized LDL and LOX-1 in Experimental Sepsis
Oxidized low-density lipoproteins (oxLDL) and the lectin-like oxLDL receptor-1 (LOX-1) are upregulated in inflammation. Because of the importance of inflammation and capillary leakage in the impairment of the microcirculation, which in turn contributes to the development of sepsis and multiorgan fai...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/761789 |
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| author | Nadia Al-Banna Christian Lehmann |
| author_facet | Nadia Al-Banna Christian Lehmann |
| author_sort | Nadia Al-Banna |
| collection | DOAJ |
| description | Oxidized low-density lipoproteins (oxLDL) and the lectin-like oxLDL receptor-1 (LOX-1) are upregulated in inflammation. Because of the importance of inflammation and capillary leakage in the impairment of the microcirculation, which in turn contributes to the development of sepsis and multiorgan failure, the role of oxidized LDL and LOX-1 as players of intestinal inflammation is of great interest. In fact, the blockade of LOX-1 during experimental endotoxemia was effective in reducing leukocyte activation. There are several mechanisms by which oxLDL can participate in local and systemic inflammation, including cell proliferation, apoptosis, capillary perfusion, leukocyte-endothelial cell interactions, and endothelial activation. This review highlights the evidence relating oxLDL and LOX-1 to proinflammatory disease mechanisms. We also indicate situations when oxLDL, because of exposure time, dose, or degree of oxidization, is involved in disease resolution. Modulation of LOX-1 response could be utilized for the treatment of local and systemic inflammation, but the successful use of this target requires further understanding of its broad effects. |
| format | Article |
| id | doaj-art-cc1f1241cae54e05b05c6f812e4be04b |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cc1f1241cae54e05b05c6f812e4be04b2025-08-20T02:19:57ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/761789761789Oxidized LDL and LOX-1 in Experimental SepsisNadia Al-Banna0Christian Lehmann1Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University Halifax, Nova Scotia, B3H 2Y9, CanadaDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University Halifax, Nova Scotia, B3H 2Y9, CanadaOxidized low-density lipoproteins (oxLDL) and the lectin-like oxLDL receptor-1 (LOX-1) are upregulated in inflammation. Because of the importance of inflammation and capillary leakage in the impairment of the microcirculation, which in turn contributes to the development of sepsis and multiorgan failure, the role of oxidized LDL and LOX-1 as players of intestinal inflammation is of great interest. In fact, the blockade of LOX-1 during experimental endotoxemia was effective in reducing leukocyte activation. There are several mechanisms by which oxLDL can participate in local and systemic inflammation, including cell proliferation, apoptosis, capillary perfusion, leukocyte-endothelial cell interactions, and endothelial activation. This review highlights the evidence relating oxLDL and LOX-1 to proinflammatory disease mechanisms. We also indicate situations when oxLDL, because of exposure time, dose, or degree of oxidization, is involved in disease resolution. Modulation of LOX-1 response could be utilized for the treatment of local and systemic inflammation, but the successful use of this target requires further understanding of its broad effects.http://dx.doi.org/10.1155/2013/761789 |
| spellingShingle | Nadia Al-Banna Christian Lehmann Oxidized LDL and LOX-1 in Experimental Sepsis Mediators of Inflammation |
| title | Oxidized LDL and LOX-1 in Experimental Sepsis |
| title_full | Oxidized LDL and LOX-1 in Experimental Sepsis |
| title_fullStr | Oxidized LDL and LOX-1 in Experimental Sepsis |
| title_full_unstemmed | Oxidized LDL and LOX-1 in Experimental Sepsis |
| title_short | Oxidized LDL and LOX-1 in Experimental Sepsis |
| title_sort | oxidized ldl and lox 1 in experimental sepsis |
| url | http://dx.doi.org/10.1155/2013/761789 |
| work_keys_str_mv | AT nadiaalbanna oxidizedldlandlox1inexperimentalsepsis AT christianlehmann oxidizedldlandlox1inexperimentalsepsis |