Assessment of the impact of pregnancy and malaria infection on the variation of neutrophil levels in women from San, Mali
Background: In patients with severe neutropenia, infections can rapidly become serious and life-threatening. It is essential to understand whether pregnancy induces changes in neutrophil levels thereby posing an increased threat to the health of gravidae. Methodology: This cross-sectional study w...
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The Journal of Infection in Developing Countries
2024-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/18409 |
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| author | Moussa Djimde Charles Arama Bouréma Koné Hamadoun Diakité Mohamed Keita Mamadou D Samaké Bréhima Tembely Balla Bagayoko Mohamed B Traoré Japhet K Tshiongo Hypolite M Mavoko Alassane Dicko Michel Vaillant Petra F Mens Henk DFH Schallig Kassoum Kayentao |
| author_facet | Moussa Djimde Charles Arama Bouréma Koné Hamadoun Diakité Mohamed Keita Mamadou D Samaké Bréhima Tembely Balla Bagayoko Mohamed B Traoré Japhet K Tshiongo Hypolite M Mavoko Alassane Dicko Michel Vaillant Petra F Mens Henk DFH Schallig Kassoum Kayentao |
| author_sort | Moussa Djimde |
| collection | DOAJ |
| description |
Background: In patients with severe neutropenia, infections can rapidly become serious and life-threatening. It is essential to understand whether pregnancy induces changes in neutrophil levels thereby posing an increased threat to the health of gravidae.
Methodology: This cross-sectional study was conducted in San Health District (Mali) and involved pregnant women infected or not by malaria parasites and non-pregnant healthy volunteers. Subjects were categorized as having neutropenia, normal neutrophil levels, and neutrophilia regarding their neutrophil levels. A logistic regression analysis was performed to determine factors associated with neutrophil level variation in pregnant women.
Results: Whether or not the pregnant women were infected with malaria, 98 of the 202 cases (48.5%) showed neutrophilia. Surprisingly, 67 of the 71 cases of neutropenia (94.4%) observed in this study concerned healthy people who were not pregnant. The mean percentage of neutrophil levels was significantly (p < 0.001) lower (49.9%) in the first trimester compared to the second trimester of pregnancy (62.0%). A logistic regression model showed that compared to early pregnancy, the second (OR = 12.9, 95% CI 2.2-248.1, p = 0.018) and the third trimesters (OR = 13.7, 95% CI 2.3-257.5, p = 0.016) were strongly associated with the increase of neutrophil levels.
Conclusions: Pregnancy can induce the production of mature neutrophils that are continually released into circulation. Neutrophil levels were lower during the first trimester of the pregnancy compared to the second and third trimesters, but not affected by the presence or absence of malaria infection.
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| format | Article |
| id | doaj-art-cc1ebf55d8784fc8a812c2241e8f7e74 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-cc1ebf55d8784fc8a812c2241e8f7e742025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802024-04-01180410.3855/jidc.18409Assessment of the impact of pregnancy and malaria infection on the variation of neutrophil levels in women from San, MaliMoussa Djimde0Charles Arama1Bouréma Koné2Hamadoun Diakité3Mohamed Keita4Mamadou D Samaké5Bréhima Tembely6Balla Bagayoko7Mohamed B Traoré8Japhet K Tshiongo9Hypolite M Mavoko10Alassane Dicko11Michel Vaillant12Petra F Mens13Henk DFH Schallig14Kassoum Kayentao15Malaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), MaliMalaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), MaliMalaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), MaliMalaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), MaliMalaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), MaliMalaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), MaliMalaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), MaliMalaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), MaliMalaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), MaliDepartment of Tropical Medicine, University of Kinshasa (UNIKIN), Kinshasa, Democratic Republic of the CongoDepartment of Tropical Medicine, University of Kinshasa (UNIKIN), Kinshasa, Democratic Republic of the CongoMalaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), MaliCentre of Competence for Methodology and Statistics (CCMS), Luxembourg Institute of Health (LIH), Strassen, LuxembourgAmsterdam University Medical Centres, Academic Medical Centre at the University of Amsterdam (AMC), Department of Medical Microbiology and Infection Prevention, Laboratory for Experimental Parasitology, Amsterdam, NetherlandsAmsterdam Institute for Infection and Immunity, Infectious Diseases Programme, Amsterdam, NetherlandsMalaria Research and Training Center (MRTC), University of Sciences of Techniques and Technologies of Bamako (USTTB), Mali Background: In patients with severe neutropenia, infections can rapidly become serious and life-threatening. It is essential to understand whether pregnancy induces changes in neutrophil levels thereby posing an increased threat to the health of gravidae. Methodology: This cross-sectional study was conducted in San Health District (Mali) and involved pregnant women infected or not by malaria parasites and non-pregnant healthy volunteers. Subjects were categorized as having neutropenia, normal neutrophil levels, and neutrophilia regarding their neutrophil levels. A logistic regression analysis was performed to determine factors associated with neutrophil level variation in pregnant women. Results: Whether or not the pregnant women were infected with malaria, 98 of the 202 cases (48.5%) showed neutrophilia. Surprisingly, 67 of the 71 cases of neutropenia (94.4%) observed in this study concerned healthy people who were not pregnant. The mean percentage of neutrophil levels was significantly (p < 0.001) lower (49.9%) in the first trimester compared to the second trimester of pregnancy (62.0%). A logistic regression model showed that compared to early pregnancy, the second (OR = 12.9, 95% CI 2.2-248.1, p = 0.018) and the third trimesters (OR = 13.7, 95% CI 2.3-257.5, p = 0.016) were strongly associated with the increase of neutrophil levels. Conclusions: Pregnancy can induce the production of mature neutrophils that are continually released into circulation. Neutrophil levels were lower during the first trimester of the pregnancy compared to the second and third trimesters, but not affected by the presence or absence of malaria infection. https://jidc.org/index.php/journal/article/view/18409NeutrophilpregnancymalariaMali |
| spellingShingle | Moussa Djimde Charles Arama Bouréma Koné Hamadoun Diakité Mohamed Keita Mamadou D Samaké Bréhima Tembely Balla Bagayoko Mohamed B Traoré Japhet K Tshiongo Hypolite M Mavoko Alassane Dicko Michel Vaillant Petra F Mens Henk DFH Schallig Kassoum Kayentao Assessment of the impact of pregnancy and malaria infection on the variation of neutrophil levels in women from San, Mali Journal of Infection in Developing Countries Neutrophil pregnancy malaria Mali |
| title | Assessment of the impact of pregnancy and malaria infection on the variation of neutrophil levels in women from San, Mali |
| title_full | Assessment of the impact of pregnancy and malaria infection on the variation of neutrophil levels in women from San, Mali |
| title_fullStr | Assessment of the impact of pregnancy and malaria infection on the variation of neutrophil levels in women from San, Mali |
| title_full_unstemmed | Assessment of the impact of pregnancy and malaria infection on the variation of neutrophil levels in women from San, Mali |
| title_short | Assessment of the impact of pregnancy and malaria infection on the variation of neutrophil levels in women from San, Mali |
| title_sort | assessment of the impact of pregnancy and malaria infection on the variation of neutrophil levels in women from san mali |
| topic | Neutrophil pregnancy malaria Mali |
| url | https://jidc.org/index.php/journal/article/view/18409 |
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