Extracellular RNA in systemic lupus erythematosus
Abstract Since the discovery of extracellular RNA (exRNA), it has been shown that exRNAs play a significant role as a transducer in intercellular communication and biomarkers in various diseases. Systemic lupus erythematosus (SLE) is a kind of autoimmune disease that has protean manifestations. The...
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| Format: | Article |
| Language: | English |
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ELS Publishing (ELSP)
2019-11-01
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| Series: | ExRNA |
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| Online Access: | http://link.springer.com/article/10.1186/s41544-019-0032-y |
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| author | Shanshan Liu Dandan Wang Yuan Liu |
| author_facet | Shanshan Liu Dandan Wang Yuan Liu |
| author_sort | Shanshan Liu |
| collection | DOAJ |
| description | Abstract Since the discovery of extracellular RNA (exRNA), it has been shown that exRNAs play a significant role as a transducer in intercellular communication and biomarkers in various diseases. Systemic lupus erythematosus (SLE) is a kind of autoimmune disease that has protean manifestations. The survival and long-term prognosis of patients with SLE has improved in these 5–10 years, while disease pathogenesis is still not clear. Many researchers found the changes in exRNA profile, and exRNAs are likely participating in the process of SLE. In this review, we summarize the current profile and function of exRNA in SLE. Circulating miRNAs, in particular, have been identified as biomarkers for SLE diagnosis. We also explore the function of lncRNA in SLE and the potential correlation with disease progression and activity. These studies show that exRNAs may take parts in the process of SLE and some of them can be used as diagnostic tool for SLE. |
| format | Article |
| id | doaj-art-cc1b76ba7b9e4f09afda9115d31a0ab6 |
| institution | Kabale University |
| issn | 2398-0060 |
| language | English |
| publishDate | 2019-11-01 |
| publisher | ELS Publishing (ELSP) |
| record_format | Article |
| series | ExRNA |
| spelling | doaj-art-cc1b76ba7b9e4f09afda9115d31a0ab62025-08-20T03:38:48ZengELS Publishing (ELSP)ExRNA2398-00602019-11-01111710.1186/s41544-019-0032-yExtracellular RNA in systemic lupus erythematosusShanshan Liu0Dandan Wang1Yuan Liu2Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolDepartment of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical SchoolProgram of Immunology & Molecular Cellular Biology, Department of Biology, Center for Diagnostics & Therapeutics, Center of Inflammation, Immunity & Infection, Georgia State UniversityAbstract Since the discovery of extracellular RNA (exRNA), it has been shown that exRNAs play a significant role as a transducer in intercellular communication and biomarkers in various diseases. Systemic lupus erythematosus (SLE) is a kind of autoimmune disease that has protean manifestations. The survival and long-term prognosis of patients with SLE has improved in these 5–10 years, while disease pathogenesis is still not clear. Many researchers found the changes in exRNA profile, and exRNAs are likely participating in the process of SLE. In this review, we summarize the current profile and function of exRNA in SLE. Circulating miRNAs, in particular, have been identified as biomarkers for SLE diagnosis. We also explore the function of lncRNA in SLE and the potential correlation with disease progression and activity. These studies show that exRNAs may take parts in the process of SLE and some of them can be used as diagnostic tool for SLE.http://link.springer.com/article/10.1186/s41544-019-0032-yexRNAsmiRNAslncRNAsSystemic lupus erythematosus |
| spellingShingle | Shanshan Liu Dandan Wang Yuan Liu Extracellular RNA in systemic lupus erythematosus ExRNA exRNAs miRNAs lncRNAs Systemic lupus erythematosus |
| title | Extracellular RNA in systemic lupus erythematosus |
| title_full | Extracellular RNA in systemic lupus erythematosus |
| title_fullStr | Extracellular RNA in systemic lupus erythematosus |
| title_full_unstemmed | Extracellular RNA in systemic lupus erythematosus |
| title_short | Extracellular RNA in systemic lupus erythematosus |
| title_sort | extracellular rna in systemic lupus erythematosus |
| topic | exRNAs miRNAs lncRNAs Systemic lupus erythematosus |
| url | http://link.springer.com/article/10.1186/s41544-019-0032-y |
| work_keys_str_mv | AT shanshanliu extracellularrnainsystemiclupuserythematosus AT dandanwang extracellularrnainsystemiclupuserythematosus AT yuanliu extracellularrnainsystemiclupuserythematosus |