Exploring the anticancer mechanism of cardiac glycosides using proteome integral solubility alteration approach

Exploring the anticancer mechanism of cardiac glycosides using proteome integral solubility alteration approach

Abstract Background and Aims Cardiac glycosides (CGs), traditionally used for heart failure, have shown potential as anti‐cancer agents. This study aims to explore their multifaceted mechanisms in cancer cell biology using proteome integral solubility alteration (PISA), focusing on the interaction w...

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Bibliographic Details
Main Authors: Wenjie Qin, Yinhua Deng, Huan Ren, Yanling Liu, Ling Liu, Wenhui Liu, Yuxi Zhao, Chen Li, Zhiling Yang
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Cancer Medicine
Subjects:
cardiac glycoside
digitoxin
digoxin
drug repositioning
drug repurposing
off‐target
Online Access:https://doi.org/10.1002/cam4.70252
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