Association between atopic dermatitis and risk of stroke: a systematic review and meta-analysis
Background/objectivesRecent studies have sought to determine the correlation between atopic dermatitis (AD) and the occurrence of stroke; however, these investigations have not reached a consensus. Consequently, our team conducted this meta-analysis and systematic review to further explore the poten...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1630671/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849470730127802368 |
|---|---|
| author | Hong Pan Qing-Ping Han Min-Ling Zeng Fang Wang Ying Xiong Bo Wu Hai-Ying Yu |
| author_facet | Hong Pan Qing-Ping Han Min-Ling Zeng Fang Wang Ying Xiong Bo Wu Hai-Ying Yu |
| author_sort | Hong Pan |
| collection | DOAJ |
| description | Background/objectivesRecent studies have sought to determine the correlation between atopic dermatitis (AD) and the occurrence of stroke; however, these investigations have not reached a consensus. Consequently, our team conducted this meta-analysis and systematic review to further explore the potential relationship between these two conditions.MethodsA comprehensive literature search was conducted across PubMed, Embase, and Web of Science from their inception until January 2025 to identify observational studies examining the association between atopic dermatitis and stroke risk. Random-effects meta-analyses were performed using the generic inverse variance method, and hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated. Additionally, sensitivity analyses and subgroup analyses were conducted to assess the stability of the results and explore potential sources of heterogeneity.ResultsThis meta-analysis included 12 observational studies, comprising 8 cohort studies, 2 case–control studies, and 3 cross-sectional studies, with a total of 14,517,146 participants. The analysis revealed a significant correlation between AD and the risk of stroke (n = 17, OR = 1.27, 95%CI = 1.14–1.43). Subgroup analyses indicated a particularly strong association among males (n = 3, OR = 1.31, 95% CI = 1.07–1.60) and in the context of ischemic stroke types (n = 5, OR = 1.14 95%CI = 1.00–1.30). Furthermore, sensitivity analyses demonstrated that the results were stable and reliable.ConclusionAD is independently associated with an increased risk of stroke, especially in men, and there is a notable association with ischemic stroke. Moreover, the risk appears to be positively correlated with the severity of AD.Systematic review registrationIdentifier INPLASY202550006. |
| format | Article |
| id | doaj-art-cc12afe77f0643fa9cbe8f5274eddb0d |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-cc12afe77f0643fa9cbe8f5274eddb0d2025-08-20T03:25:04ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-07-011610.3389/fneur.2025.16306711630671Association between atopic dermatitis and risk of stroke: a systematic review and meta-analysisHong Pan0Qing-Ping Han1Min-Ling Zeng2Fang Wang3Ying Xiong4Bo Wu5Hai-Ying Yu6Department of Internal Medicine, Shenzhen Maternity and Child Healthcare Hospital, Women and Children’s Medical Center, Southern Medical University, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children’s Medical Center, Southern Medical University, Shenzhen, Guangdong, ChinaDepartment of Neurology, The Third Clinical Medical College of China Three Gorges University, Gezhouba Central Hospital of Sinopharm, Yichang, ChinaDepartment of Internal Medicine, Shenzhen Maternity and Child Healthcare Hospital, Women and Children’s Medical Center, Southern Medical University, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children’s Medical Center, Southern Medical University, Shenzhen, Guangdong, ChinaDepartment of Dermatology, Shenzhen Maternity and Child Healthcare Hospital, Women and Children’s Medical Center, Southern Medical University, Shenzhen, Guangdong, ChinaDepartment of Internal Medicine, Shenzhen Maternity and Child Healthcare Hospital, Women and Children’s Medical Center, Southern Medical University, Shenzhen, Guangdong, ChinaBackground/objectivesRecent studies have sought to determine the correlation between atopic dermatitis (AD) and the occurrence of stroke; however, these investigations have not reached a consensus. Consequently, our team conducted this meta-analysis and systematic review to further explore the potential relationship between these two conditions.MethodsA comprehensive literature search was conducted across PubMed, Embase, and Web of Science from their inception until January 2025 to identify observational studies examining the association between atopic dermatitis and stroke risk. Random-effects meta-analyses were performed using the generic inverse variance method, and hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated. Additionally, sensitivity analyses and subgroup analyses were conducted to assess the stability of the results and explore potential sources of heterogeneity.ResultsThis meta-analysis included 12 observational studies, comprising 8 cohort studies, 2 case–control studies, and 3 cross-sectional studies, with a total of 14,517,146 participants. The analysis revealed a significant correlation between AD and the risk of stroke (n = 17, OR = 1.27, 95%CI = 1.14–1.43). Subgroup analyses indicated a particularly strong association among males (n = 3, OR = 1.31, 95% CI = 1.07–1.60) and in the context of ischemic stroke types (n = 5, OR = 1.14 95%CI = 1.00–1.30). Furthermore, sensitivity analyses demonstrated that the results were stable and reliable.ConclusionAD is independently associated with an increased risk of stroke, especially in men, and there is a notable association with ischemic stroke. Moreover, the risk appears to be positively correlated with the severity of AD.Systematic review registrationIdentifier INPLASY202550006.https://www.frontiersin.org/articles/10.3389/fneur.2025.1630671/fullatopic dermatitisstrokemeta-analysisrisksystematic review |
| spellingShingle | Hong Pan Qing-Ping Han Min-Ling Zeng Fang Wang Ying Xiong Bo Wu Hai-Ying Yu Association between atopic dermatitis and risk of stroke: a systematic review and meta-analysis Frontiers in Neurology atopic dermatitis stroke meta-analysis risk systematic review |
| title | Association between atopic dermatitis and risk of stroke: a systematic review and meta-analysis |
| title_full | Association between atopic dermatitis and risk of stroke: a systematic review and meta-analysis |
| title_fullStr | Association between atopic dermatitis and risk of stroke: a systematic review and meta-analysis |
| title_full_unstemmed | Association between atopic dermatitis and risk of stroke: a systematic review and meta-analysis |
| title_short | Association between atopic dermatitis and risk of stroke: a systematic review and meta-analysis |
| title_sort | association between atopic dermatitis and risk of stroke a systematic review and meta analysis |
| topic | atopic dermatitis stroke meta-analysis risk systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1630671/full |
| work_keys_str_mv | AT hongpan associationbetweenatopicdermatitisandriskofstrokeasystematicreviewandmetaanalysis AT qingpinghan associationbetweenatopicdermatitisandriskofstrokeasystematicreviewandmetaanalysis AT minlingzeng associationbetweenatopicdermatitisandriskofstrokeasystematicreviewandmetaanalysis AT fangwang associationbetweenatopicdermatitisandriskofstrokeasystematicreviewandmetaanalysis AT yingxiong associationbetweenatopicdermatitisandriskofstrokeasystematicreviewandmetaanalysis AT bowu associationbetweenatopicdermatitisandriskofstrokeasystematicreviewandmetaanalysis AT haiyingyu associationbetweenatopicdermatitisandriskofstrokeasystematicreviewandmetaanalysis |