DII modulates the relationship between SVD3 and NAFLD prevalence, rather than liver fibrosis severity, in hospitalized T2DM population
Abstract Type 2 diabetes (T2DM) patients are at high risk for non-alcoholic fatty liver disease (NAFLD). Studies show SVD3 and dietary inflammatory index (DII) are associated with NAFLD. It’s unknown if they interact in T2DM patients with NAFLD. We collected data from 110 hospitalized T2DM patients,...
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Nature Portfolio
2024-10-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-76560-1 |
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| author | Wei Xiang Shi Cheng Yuan Peng Qiong Jin Jun Yang |
| author_facet | Wei Xiang Shi Cheng Yuan Peng Qiong Jin Jun Yang |
| author_sort | Wei Xiang |
| collection | DOAJ |
| description | Abstract Type 2 diabetes (T2DM) patients are at high risk for non-alcoholic fatty liver disease (NAFLD). Studies show SVD3 and dietary inflammatory index (DII) are associated with NAFLD. It’s unknown if they interact in T2DM patients with NAFLD. We collected data from 110 hospitalized T2DM patients, measured physiological and biochemical indicators, conducted dietary surveys, and converted data into DII and NFS, FIB-4, and BARD indices. We used logistic regression, mediation effect analysis, and moderation effect analysis to explore the relationship between DII and SVD3 with NAFLD and liver fibrosis in T2DM patients. DII was not significant in either NAFLD incidence in T2DM patients or liver fibrosis in NAFLD patients. SVD3 was positively correlated with NAFLD incidence in T2DM patients, but this correlation became insignificant as DII increased towards pro-inflammation. SVD3 is positively correlated with NAFLD incidence in T2DM patients, but this correlation becomes less significant as DII increases towards pro-inflammation. |
| format | Article |
| id | doaj-art-cc103aeb08bc43438aececc741e81816 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-cc103aeb08bc43438aececc741e818162025-08-20T02:11:22ZengNature PortfolioScientific Reports2045-23222024-10-0114111110.1038/s41598-024-76560-1DII modulates the relationship between SVD3 and NAFLD prevalence, rather than liver fibrosis severity, in hospitalized T2DM populationWei Xiang0Shi Cheng1Yuan Peng2Qiong Jin3Jun Yang4Department of Nutrition, Changzhou Hospital of Traditional Chinese MedicineDepartment of Food and Environmental Diseases, Changzhou Center for Disease Control and PreventionDepartment of Endocrinology, Changzhou Hospital of Traditional Chinese MedicineDepartment of Nutrition, Changzhou Hospital of Traditional Chinese MedicineDepartment of Endocrinology, Changzhou Hospital of Traditional Chinese MedicineAbstract Type 2 diabetes (T2DM) patients are at high risk for non-alcoholic fatty liver disease (NAFLD). Studies show SVD3 and dietary inflammatory index (DII) are associated with NAFLD. It’s unknown if they interact in T2DM patients with NAFLD. We collected data from 110 hospitalized T2DM patients, measured physiological and biochemical indicators, conducted dietary surveys, and converted data into DII and NFS, FIB-4, and BARD indices. We used logistic regression, mediation effect analysis, and moderation effect analysis to explore the relationship between DII and SVD3 with NAFLD and liver fibrosis in T2DM patients. DII was not significant in either NAFLD incidence in T2DM patients or liver fibrosis in NAFLD patients. SVD3 was positively correlated with NAFLD incidence in T2DM patients, but this correlation became insignificant as DII increased towards pro-inflammation. SVD3 is positively correlated with NAFLD incidence in T2DM patients, but this correlation becomes less significant as DII increases towards pro-inflammation.https://doi.org/10.1038/s41598-024-76560-1Dietary inflammatory indexVitamin DNon-alcoholic fatty liver diseaseType 2 diabetes mellitusModeration effect |
| spellingShingle | Wei Xiang Shi Cheng Yuan Peng Qiong Jin Jun Yang DII modulates the relationship between SVD3 and NAFLD prevalence, rather than liver fibrosis severity, in hospitalized T2DM population Scientific Reports Dietary inflammatory index Vitamin D Non-alcoholic fatty liver disease Type 2 diabetes mellitus Moderation effect |
| title | DII modulates the relationship between SVD3 and NAFLD prevalence, rather than liver fibrosis severity, in hospitalized T2DM population |
| title_full | DII modulates the relationship between SVD3 and NAFLD prevalence, rather than liver fibrosis severity, in hospitalized T2DM population |
| title_fullStr | DII modulates the relationship between SVD3 and NAFLD prevalence, rather than liver fibrosis severity, in hospitalized T2DM population |
| title_full_unstemmed | DII modulates the relationship between SVD3 and NAFLD prevalence, rather than liver fibrosis severity, in hospitalized T2DM population |
| title_short | DII modulates the relationship between SVD3 and NAFLD prevalence, rather than liver fibrosis severity, in hospitalized T2DM population |
| title_sort | dii modulates the relationship between svd3 and nafld prevalence rather than liver fibrosis severity in hospitalized t2dm population |
| topic | Dietary inflammatory index Vitamin D Non-alcoholic fatty liver disease Type 2 diabetes mellitus Moderation effect |
| url | https://doi.org/10.1038/s41598-024-76560-1 |
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