Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E

Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E

BackgroundThe dismal efficacy of immunotherapy for Pancreatic cancer (PC) can be predominantly ascribed to its distinctive cold-tumor properties. The by-products of purine metabolic reprogramming are extensively engaged in tumor immune modulation, influencing the functions and recruitment of immune...

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Bibliographic Details
Main Authors:	Junqian Zhang, Xiaobo Zhang, Ruixin Wu, Chang-Sheng Dong
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-04-01
Series:	Frontiers in Immunology
Subjects:	purine metabolism immunotherapy CAFs NT5E pancreatic cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1569088/full
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