Preoperative Antibiotic Administration Does Not Improve the Outcomes of Operated Diabetic Foot Infections

Many patients with community-acquired diabetic foot infections (DFI) receive systemic (empirical) antibiotic treatments before surgical interventions, often by the general practitioner. Sometimes, hospital clinicians prescribe them before surgery to reduce the infection inoculum and preserve soft ti...

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Main Authors: Thaddaeus Muri, Madlaina Schöni, Felix W. A. Waibel, Dominique Altmann, Christina Sydler, Pascal R. Furrer, Francesca Napoli, İlker Uçkay
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Antibiotics
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Online Access:https://www.mdpi.com/2079-6382/13/12/1136
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author Thaddaeus Muri
Madlaina Schöni
Felix W. A. Waibel
Dominique Altmann
Christina Sydler
Pascal R. Furrer
Francesca Napoli
İlker Uçkay
author_facet Thaddaeus Muri
Madlaina Schöni
Felix W. A. Waibel
Dominique Altmann
Christina Sydler
Pascal R. Furrer
Francesca Napoli
İlker Uçkay
author_sort Thaddaeus Muri
collection DOAJ
description Many patients with community-acquired diabetic foot infections (DFI) receive systemic (empirical) antibiotic treatments before surgical interventions, often by the general practitioner. Sometimes, hospital clinicians prescribe them before surgery to reduce the infection inoculum and preserve soft tissue for immediate wound closure in case of residual infection after surgery. In contrast, the international guidelines (IWGDF) advocate against presurgical antibiotic use in routine situations without severe progredient soft tissue infections and/or sepsis. We run several retrospective and prospective cohorts of DFI and retrospectively analyze the influence of presurgical antibiotic therapy (as binary (yes/no) or continuous (in days) variables) on failures after a combined surgical and medical treatment. In our large database, the presence, choice, administration routes, or duration of preoperative antibiotic therapy did not improve the postoperative outcomes of operated diabetic foot infections or prevent their failures. In turn, this lack of influence leaves space for enhanced antibiotic stewardship in the management of DFI.
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series Antibiotics
spelling doaj-art-cc0f05a300af466fbafc91c9b640639e2025-08-20T02:53:18ZengMDPI AGAntibiotics2079-63822024-11-011312113610.3390/antibiotics13121136Preoperative Antibiotic Administration Does Not Improve the Outcomes of Operated Diabetic Foot InfectionsThaddaeus Muri0Madlaina Schöni1Felix W. A. Waibel2Dominique Altmann3Christina Sydler4Pascal R. Furrer5Francesca Napoli6İlker Uçkay7Technical Orthopedics and Neuro-Orthopedics Team, Department of Orthopedic Surgery, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, SwitzerlandTechnical Orthopedics and Neuro-Orthopedics Team, Department of Orthopedic Surgery, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, SwitzerlandTechnical Orthopedics and Neuro-Orthopedics Team, Department of Orthopedic Surgery, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, SwitzerlandTechnical Orthopedics and Neuro-Orthopedics Team, Department of Orthopedic Surgery, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, SwitzerlandTechnical Orthopedics and Neuro-Orthopedics Team, Department of Orthopedic Surgery, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, SwitzerlandTechnical Orthopedics and Neuro-Orthopedics Team, Department of Orthopedic Surgery, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, SwitzerlandTechnical Orthopedics and Neuro-Orthopedics Team, Department of Orthopedic Surgery, Balgrist University Hospital, Forchstrasse 340, 8008 Zurich, SwitzerlandInfectiology, Balgrist University Hospital, 8008 Zurich, SwitzerlandMany patients with community-acquired diabetic foot infections (DFI) receive systemic (empirical) antibiotic treatments before surgical interventions, often by the general practitioner. Sometimes, hospital clinicians prescribe them before surgery to reduce the infection inoculum and preserve soft tissue for immediate wound closure in case of residual infection after surgery. In contrast, the international guidelines (IWGDF) advocate against presurgical antibiotic use in routine situations without severe progredient soft tissue infections and/or sepsis. We run several retrospective and prospective cohorts of DFI and retrospectively analyze the influence of presurgical antibiotic therapy (as binary (yes/no) or continuous (in days) variables) on failures after a combined surgical and medical treatment. In our large database, the presence, choice, administration routes, or duration of preoperative antibiotic therapy did not improve the postoperative outcomes of operated diabetic foot infections or prevent their failures. In turn, this lack of influence leaves space for enhanced antibiotic stewardship in the management of DFI.https://www.mdpi.com/2079-6382/13/12/1136diabetic foot infectionorthopedic surgerypreoperative antibioticspostoperative antibioticsantibiotic durationoutcome
spellingShingle Thaddaeus Muri
Madlaina Schöni
Felix W. A. Waibel
Dominique Altmann
Christina Sydler
Pascal R. Furrer
Francesca Napoli
İlker Uçkay
Preoperative Antibiotic Administration Does Not Improve the Outcomes of Operated Diabetic Foot Infections
Antibiotics
diabetic foot infection
orthopedic surgery
preoperative antibiotics
postoperative antibiotics
antibiotic duration
outcome
title Preoperative Antibiotic Administration Does Not Improve the Outcomes of Operated Diabetic Foot Infections
title_full Preoperative Antibiotic Administration Does Not Improve the Outcomes of Operated Diabetic Foot Infections
title_fullStr Preoperative Antibiotic Administration Does Not Improve the Outcomes of Operated Diabetic Foot Infections
title_full_unstemmed Preoperative Antibiotic Administration Does Not Improve the Outcomes of Operated Diabetic Foot Infections
title_short Preoperative Antibiotic Administration Does Not Improve the Outcomes of Operated Diabetic Foot Infections
title_sort preoperative antibiotic administration does not improve the outcomes of operated diabetic foot infections
topic diabetic foot infection
orthopedic surgery
preoperative antibiotics
postoperative antibiotics
antibiotic duration
outcome
url https://www.mdpi.com/2079-6382/13/12/1136
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