Nitric Oxide Levels in Patients with Psoriasis Treated with Methotrexate
Psoriasis is a chronic, recurrent, inflammatory, and hyperproliferative disease. Recently there have been studies regarding increases in the levels of NO in inflammatory dermatoses including psoriasis. In this study, 22 patients with psoriasis were scored with PASI (psoriasis area and severity inde...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/16043 |
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| author | Nilgun Solak Tekin Nilsel Ilter Banu Sancak Muge Guler Ozden Mehmet Ali Gurer |
| author_facet | Nilgun Solak Tekin Nilsel Ilter Banu Sancak Muge Guler Ozden Mehmet Ali Gurer |
| author_sort | Nilgun Solak Tekin |
| collection | DOAJ |
| description | Psoriasis is a chronic, recurrent, inflammatory, and hyperproliferative disease. Recently there have been studies regarding increases in the levels of NO in inflammatory dermatoses including psoriasis. In this study, 22 patients with psoriasis were scored with PASI (psoriasis area and severity index) and the levels of serum nitrite-nitrate were evaluated before and after therapy with methotrexate (Mtx). The results were compared with age- and sex-matched healthy volunteers. The relation of the results with the clinical severity and the cumulative Mtx dose were also evaluated. The serum levels of nitrite-nitrate of the psoriatic patients with active lesions were
found to be significantly higher than the levels of the healthy volunteers and the patients after therapy. The elevated
nitrite-nitrate serum levels in the inflammatory period may suggest the possible role of this mediator in the etiopathogenesis of psoriasis and the potential future use of NO inhibitors in the treatment of psoriasis. |
| format | Article |
| id | doaj-art-cc0efa435a8743b6a6839a10a3497eb5 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-cc0efa435a8743b6a6839a10a3497eb52025-02-03T06:13:19ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/1604316043Nitric Oxide Levels in Patients with Psoriasis Treated with MethotrexateNilgun Solak Tekin0Nilsel Ilter1Banu Sancak2Muge Guler Ozden3Mehmet Ali Gurer4Department of Dermatology, Medical Faculty, Zonguldak Karaelmas University, Zonguldak 67600, TurkeyDepartment of Dermatology, Medical Faculty, Gazi University, Ankara 06100, TurkeyDepartment of Biochemistry, Medical Faculty, Gazi University, Ankara 06100, TurkeyDepartment of Dermatology, Medical Faculty, Yeditepe University, Istanbul 34100, TurkeyDepartment of Dermatology, Medical Faculty, Gazi University, Ankara 06100, TurkeyPsoriasis is a chronic, recurrent, inflammatory, and hyperproliferative disease. Recently there have been studies regarding increases in the levels of NO in inflammatory dermatoses including psoriasis. In this study, 22 patients with psoriasis were scored with PASI (psoriasis area and severity index) and the levels of serum nitrite-nitrate were evaluated before and after therapy with methotrexate (Mtx). The results were compared with age- and sex-matched healthy volunteers. The relation of the results with the clinical severity and the cumulative Mtx dose were also evaluated. The serum levels of nitrite-nitrate of the psoriatic patients with active lesions were found to be significantly higher than the levels of the healthy volunteers and the patients after therapy. The elevated nitrite-nitrate serum levels in the inflammatory period may suggest the possible role of this mediator in the etiopathogenesis of psoriasis and the potential future use of NO inhibitors in the treatment of psoriasis.http://dx.doi.org/10.1155/MI/2006/16043 |
| spellingShingle | Nilgun Solak Tekin Nilsel Ilter Banu Sancak Muge Guler Ozden Mehmet Ali Gurer Nitric Oxide Levels in Patients with Psoriasis Treated with Methotrexate Mediators of Inflammation |
| title | Nitric Oxide Levels in Patients with Psoriasis Treated with Methotrexate |
| title_full | Nitric Oxide Levels in Patients with Psoriasis Treated with Methotrexate |
| title_fullStr | Nitric Oxide Levels in Patients with Psoriasis Treated with Methotrexate |
| title_full_unstemmed | Nitric Oxide Levels in Patients with Psoriasis Treated with Methotrexate |
| title_short | Nitric Oxide Levels in Patients with Psoriasis Treated with Methotrexate |
| title_sort | nitric oxide levels in patients with psoriasis treated with methotrexate |
| url | http://dx.doi.org/10.1155/MI/2006/16043 |
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