Effects of Ursolic Acid and its Analogues on Soybean 15-Lipoxygenase Activity and the Proliferation Rate of A human Gastric Tumour Cell Line
The authors have previously isolated and purified ursolic acid from heather flowers (Calluna vulgarts). This terpene was found to inhibit HL-60 leukaemic cell proliferation and arachidonic acid oxidative metabolism in various cell species. The effects of ursolic acid and its analogues on soybean 15-...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000244 |
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| Summary: | The authors have previously isolated and purified ursolic acid from
heather flowers (Calluna vulgarts). This terpene was found to
inhibit HL-60 leukaemic cell proliferation and arachidonic acid
oxidative metabolism in various cell species. The effects of ursolic
acid and its analogues on soybean 15-lipoxygenase activity and on
the proliferation of a human gastric tumour cell line (HGT), have
been assessed. These triterpenes inhibited soybean 15-lipoxygenase
at its optimal activity (pH 9). The proliferation ofHGT was
decreased in a dose-dependent manner. At 20 μM the rank order is:
ursolic acid > uvaol > oleanolic acid > methyl ursolate. The
carboxylic group at the C28 position of ursolic acid appears to be
implicated in the inhibition of both lipoxygenase activity and cell
proliferation. Thus methylation of this group decreases these two
inhibitory properties. Oleanolic acid, which differs by the position
of one methyl group (C20 instead of C19) is less inhibitory than
ursolic acid. The lipophilicity of the terpene is also implicated
since uvaol appears to be more inhibitory than methyl ursolate. |
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| ISSN: | 0962-9351 1466-1861 |