Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study
To date, there remains a paucity of prospective studies examining the association between premature ovarian insufficiency (POI) and cardiovascular diseases (CVD). The objective of this study was to investigate the potential association between POI and CVD utilizing the method of Mendelian randomizat...
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Taylor & Francis Group
2025-12-01
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| Series: | Gynecological Endocrinology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09513590.2025.2487498 |
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| author | Xinyun Yang Tongtong Lin Lina Luo Hao Chen Yifei Dai Dingheng Li Linling Zhu |
| author_facet | Xinyun Yang Tongtong Lin Lina Luo Hao Chen Yifei Dai Dingheng Li Linling Zhu |
| author_sort | Xinyun Yang |
| collection | DOAJ |
| description | To date, there remains a paucity of prospective studies examining the association between premature ovarian insufficiency (POI) and cardiovascular diseases (CVD). The objective of this study was to investigate the potential association between POI and CVD utilizing the method of Mendelian randomization (MR). MR analyses utilized summary statistics from the most extensive genome-wide association studies (GWAS) on POI and CVD extracted from European ancestry cohorts and the FinnGen biobank. The inverse variance-weighted (IVW) method was the primary MR analysis technique. Supplementary analyses were performed using MR-Robust Adjusted Profile Score (MR-RAPS). Cochran’s Q statistic, MR-Egger, and weighted median MR models were employed to further assess heterogeneity and horizontal pleiotropy. Causal effects of POI on coronary heart disease (odds ratio [OR] = 1.048, 95% confidence interval [CI]: 1.006–1.091; p = 0.023)] and ischemic stroke (OR = 1.010, 95% CI: 1.000-1.020; p = 0.0498) were found. However, we did not observe a significant correlation between POI and hypertension (OR = 0.999, 95% CI: 0.994-1.004, p = 0.691), heart failure (OR = 1.009, 95% CI: 0.999-1.020, p = 0.0725), atrial fibrillation (OR = 0.995, 95% CI: 0.986-1.004, p = 0.3035), and myocardial infarction (OR = 1.002, 95% CI: 0.991-1.013, p = 0.7061). POI was causally associated with coronary heart disease and ischemic stroke, with no apparent impact on hypertension, heart failure, atrial fibrillation, or myocardial infarction. The causal relationship between POI and CVD underscores the imperative for proactive cardiovascular risk management in individuals with POI. |
| format | Article |
| id | doaj-art-cc0b5ff152a7472391397d3c4ef23b9a |
| institution | OA Journals |
| issn | 0951-3590 1473-0766 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
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| series | Gynecological Endocrinology |
| spelling | doaj-art-cc0b5ff152a7472391397d3c4ef23b9a2025-08-20T01:52:23ZengTaylor & Francis GroupGynecological Endocrinology0951-35901473-07662025-12-0141110.1080/09513590.2025.2487498Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization studyXinyun Yang0Tongtong Lin1Lina Luo2Hao Chen3Yifei Dai4Dingheng Li5Linling Zhu6Department of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaDepartment of Gynecology, Hangzhou Fuyang Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, ChinaDepartment of Pathology, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, ChinaDepartment of Gynecology, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, ChinaDepartment of Gynecology, Hangzhou Women’s Hospital, Hangzhou, Zhejiang, ChinaDepartment of Reproductive Endocrinology, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, ChinaTo date, there remains a paucity of prospective studies examining the association between premature ovarian insufficiency (POI) and cardiovascular diseases (CVD). The objective of this study was to investigate the potential association between POI and CVD utilizing the method of Mendelian randomization (MR). MR analyses utilized summary statistics from the most extensive genome-wide association studies (GWAS) on POI and CVD extracted from European ancestry cohorts and the FinnGen biobank. The inverse variance-weighted (IVW) method was the primary MR analysis technique. Supplementary analyses were performed using MR-Robust Adjusted Profile Score (MR-RAPS). Cochran’s Q statistic, MR-Egger, and weighted median MR models were employed to further assess heterogeneity and horizontal pleiotropy. Causal effects of POI on coronary heart disease (odds ratio [OR] = 1.048, 95% confidence interval [CI]: 1.006–1.091; p = 0.023)] and ischemic stroke (OR = 1.010, 95% CI: 1.000-1.020; p = 0.0498) were found. However, we did not observe a significant correlation between POI and hypertension (OR = 0.999, 95% CI: 0.994-1.004, p = 0.691), heart failure (OR = 1.009, 95% CI: 0.999-1.020, p = 0.0725), atrial fibrillation (OR = 0.995, 95% CI: 0.986-1.004, p = 0.3035), and myocardial infarction (OR = 1.002, 95% CI: 0.991-1.013, p = 0.7061). POI was causally associated with coronary heart disease and ischemic stroke, with no apparent impact on hypertension, heart failure, atrial fibrillation, or myocardial infarction. The causal relationship between POI and CVD underscores the imperative for proactive cardiovascular risk management in individuals with POI.https://www.tandfonline.com/doi/10.1080/09513590.2025.2487498Mendelian randomizationpremature ovarian insufficiencycardiovascular diseasescoronary heart diseaseischemic stroke |
| spellingShingle | Xinyun Yang Tongtong Lin Lina Luo Hao Chen Yifei Dai Dingheng Li Linling Zhu Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study Gynecological Endocrinology Mendelian randomization premature ovarian insufficiency cardiovascular diseases coronary heart disease ischemic stroke |
| title | Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study |
| title_full | Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study |
| title_fullStr | Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study |
| title_full_unstemmed | Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study |
| title_short | Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study |
| title_sort | causal associations between premature ovarian insufficiency and cardiovascular diseases a mendelian randomization study |
| topic | Mendelian randomization premature ovarian insufficiency cardiovascular diseases coronary heart disease ischemic stroke |
| url | https://www.tandfonline.com/doi/10.1080/09513590.2025.2487498 |
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