Kinase activity of DYRK family members is required for regulating primary cilium length, stability and morphology
Abstract The dual-specificity tyrosine-phoshorylation-regulated kinase (DYRK) family are multifunctional enzymes crucial for diverse cellular processes, including signaling through the primary cilium. Their dysregulation has been implicated in various cancers and developmental disorders, highlightin...
Saved in:
| Main Authors: | Melis D. Arslanhan, Ebru Topçu, Elif Nur Firat-Karalar |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-08-01
|
| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08373-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Differential regulation of expression of the protein kinases DYRK1A and DYRK1B in cancer cells
by: Vincent Andreas Vorwerk, et al.
Published: (2024-10-01) -
DLK-1/p38 MAP Kinase Signaling Controls Cilium Length by Regulating RAB-5 Mediated Endocytosis in Caenorhabditis elegans.
by: Aniek van der Vaart, et al.
Published: (2015-12-01) -
GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.
by: Madison F Walker, et al.
Published: (2024-08-01) -
Discovery of Dietary Plant Flavonols as Novel Potent Inhibitors Targeting DYRK1A Kinase
by: Jin Jin, et al.
Published: (2025-06-01) -
Minimal design of a synthetic cilium
by: Clément Moreau, et al.
Published: (2024-12-01)