Development of a physiologically‐based pharmacokinetic model to simulate the pharmacokinetics of intramuscular antiretroviral drugs

Abstract There is growing interest in the use of long‐acting (LA) injectable drugs to improve treatment adherence. However, their long elimination half‐life complicates the conduct of clinical trials. Physiologically‐based pharmacokinetic (PBPK) modeling is a mathematical tool that allows to simulat...

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Bibliographic Details
Main Authors: Sara Bettonte, Mattia Berton, Manuel Battegay, Felix Stader, Catia Marzolini
Format: Article
Language:English
Published: Wiley 2024-05-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.13118
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