Complete Resolution of Bulky Cutaneous Squamous Cell Carcinoma by Programmed Death-1 Inhibitor
A 94-year-old White man presented for the treatment of a recurrent cutaneous squamous cell carcinoma of the forehead. The lesion started 1 year ago and was treated initially with electrodesiccation and curettage followed by topical fluorouracil. At recurrence, the patient was offered surgery and rad...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2024-03-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0570 |
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| author | Sach Thakker Jafar Al-Mondhiry |
| author_facet | Sach Thakker Jafar Al-Mondhiry |
| author_sort | Sach Thakker |
| collection | DOAJ |
| description | A 94-year-old White man presented for the treatment of a recurrent cutaneous squamous cell carcinoma of the forehead. The lesion started 1 year ago and was treated initially with electrodesiccation and curettage followed by topical fluorouracil. At recurrence, the patient was offered surgery and radiation therapy but opted for systemic therapy targeting programmed death-1 inhibition (pembrolizumab). Accelerated regression and complete resolution of the tumor was observed after the first 3 infusions with no major side effects. Immunotherapy represents a major step forward in the treatment of advanced cutaneous squamous cell carcinoma, with high efficacy and a modest side effect profile favorable for many patients. |
| format | Article |
| id | doaj-art-cc01a9dc6dbe44feb9b7f16b59cf767e |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-cc01a9dc6dbe44feb9b7f16b59cf767e2025-08-20T02:12:58ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642024-03-013310.7326/aimcc.2023.0570Complete Resolution of Bulky Cutaneous Squamous Cell Carcinoma by Programmed Death-1 InhibitorSach Thakker0Jafar Al-Mondhiry11Georgetown University School of Medicine, Washington, DC2Inova Schar Cancer Institute, Fairfax, VirginiaA 94-year-old White man presented for the treatment of a recurrent cutaneous squamous cell carcinoma of the forehead. The lesion started 1 year ago and was treated initially with electrodesiccation and curettage followed by topical fluorouracil. At recurrence, the patient was offered surgery and radiation therapy but opted for systemic therapy targeting programmed death-1 inhibition (pembrolizumab). Accelerated regression and complete resolution of the tumor was observed after the first 3 infusions with no major side effects. Immunotherapy represents a major step forward in the treatment of advanced cutaneous squamous cell carcinoma, with high efficacy and a modest side effect profile favorable for many patients.https://www.acpjournals.org/doi/10.7326/aimcc.2023.0570 |
| spellingShingle | Sach Thakker Jafar Al-Mondhiry Complete Resolution of Bulky Cutaneous Squamous Cell Carcinoma by Programmed Death-1 Inhibitor Annals of Internal Medicine: Clinical Cases |
| title | Complete Resolution of Bulky Cutaneous Squamous Cell Carcinoma by Programmed Death-1 Inhibitor |
| title_full | Complete Resolution of Bulky Cutaneous Squamous Cell Carcinoma by Programmed Death-1 Inhibitor |
| title_fullStr | Complete Resolution of Bulky Cutaneous Squamous Cell Carcinoma by Programmed Death-1 Inhibitor |
| title_full_unstemmed | Complete Resolution of Bulky Cutaneous Squamous Cell Carcinoma by Programmed Death-1 Inhibitor |
| title_short | Complete Resolution of Bulky Cutaneous Squamous Cell Carcinoma by Programmed Death-1 Inhibitor |
| title_sort | complete resolution of bulky cutaneous squamous cell carcinoma by programmed death 1 inhibitor |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0570 |
| work_keys_str_mv | AT sachthakker completeresolutionofbulkycutaneoussquamouscellcarcinomabyprogrammeddeath1inhibitor AT jafaralmondhiry completeresolutionofbulkycutaneoussquamouscellcarcinomabyprogrammeddeath1inhibitor |