NiO Nanoparticles: An Efficient Catalyst for the Multicomponent One-Pot Synthesis of Novel Spiro and Condensed Indole Derivatives

An efficient catalytic protocol for the synthesis of novel spiro[indoline-3,4′-pyrano[2,3-c]thiazole]carbonitriles and condensed thiazolo[5′′,4′′:5′,6′]pyrano[4′,3′:3,4]furo[2,3-b]indole derivatives is developed in a one-pot three-component approach involving substituted 1H-indole-2,3-diones, activ...

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Main Authors: Harshita Sachdeva, Diksha Dwivedi, R. R. Bhattacharjee, Sarita Khaturia, Rekha Saroj
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2013/606259
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author Harshita Sachdeva
Diksha Dwivedi
R. R. Bhattacharjee
Sarita Khaturia
Rekha Saroj
author_facet Harshita Sachdeva
Diksha Dwivedi
R. R. Bhattacharjee
Sarita Khaturia
Rekha Saroj
author_sort Harshita Sachdeva
collection DOAJ
description An efficient catalytic protocol for the synthesis of novel spiro[indoline-3,4′-pyrano[2,3-c]thiazole]carbonitriles and condensed thiazolo[5′′,4′′:5′,6′]pyrano[4′,3′:3,4]furo[2,3-b]indole derivatives is developed in a one-pot three-component approach involving substituted 1H-indole-2,3-diones, activated methylene reagent, and 2-thioxo-4-thiazolidinone under conventional heating and microwave irradiation. This paper describes the use of NiO nanoparticles as catalyst for the synthesis of novel spiro and condensed indole derivatives by Knoevenagel condensation followed by Michael addition. The advantageous features of this methodology are operational simplicity, high yield processing, and easy handling. The particle size of NiO nanoparticle was determined by XRD. After reaction course, NiO nanoparticles can be recycled and reused without any apparent loss of activity.
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institution Kabale University
issn 2090-9063
2090-9071
language English
publishDate 2013-01-01
publisher Wiley
record_format Article
series Journal of Chemistry
spelling doaj-art-cc008a58da6a40c4912eccfa8b317d4d2025-02-03T07:24:48ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/606259606259NiO Nanoparticles: An Efficient Catalyst for the Multicomponent One-Pot Synthesis of Novel Spiro and Condensed Indole DerivativesHarshita Sachdeva0Diksha Dwivedi1R. R. Bhattacharjee2Sarita Khaturia3Rekha Saroj4Department of Chemistry, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Sikar, Rajasthan, Lakshmangarh 332311, IndiaDepartment of Chemistry, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Sikar, Rajasthan, Lakshmangarh 332311, IndiaDepartment of Chemistry, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Sikar, Rajasthan, Lakshmangarh 332311, IndiaDepartment of Chemistry, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Sikar, Rajasthan, Lakshmangarh 332311, IndiaDepartment of Chemistry, Faculty of Engineering and Technology, Mody Institute of Technology and Science, Sikar, Rajasthan, Lakshmangarh 332311, IndiaAn efficient catalytic protocol for the synthesis of novel spiro[indoline-3,4′-pyrano[2,3-c]thiazole]carbonitriles and condensed thiazolo[5′′,4′′:5′,6′]pyrano[4′,3′:3,4]furo[2,3-b]indole derivatives is developed in a one-pot three-component approach involving substituted 1H-indole-2,3-diones, activated methylene reagent, and 2-thioxo-4-thiazolidinone under conventional heating and microwave irradiation. This paper describes the use of NiO nanoparticles as catalyst for the synthesis of novel spiro and condensed indole derivatives by Knoevenagel condensation followed by Michael addition. The advantageous features of this methodology are operational simplicity, high yield processing, and easy handling. The particle size of NiO nanoparticle was determined by XRD. After reaction course, NiO nanoparticles can be recycled and reused without any apparent loss of activity.http://dx.doi.org/10.1155/2013/606259
spellingShingle Harshita Sachdeva
Diksha Dwivedi
R. R. Bhattacharjee
Sarita Khaturia
Rekha Saroj
NiO Nanoparticles: An Efficient Catalyst for the Multicomponent One-Pot Synthesis of Novel Spiro and Condensed Indole Derivatives
Journal of Chemistry
title NiO Nanoparticles: An Efficient Catalyst for the Multicomponent One-Pot Synthesis of Novel Spiro and Condensed Indole Derivatives
title_full NiO Nanoparticles: An Efficient Catalyst for the Multicomponent One-Pot Synthesis of Novel Spiro and Condensed Indole Derivatives
title_fullStr NiO Nanoparticles: An Efficient Catalyst for the Multicomponent One-Pot Synthesis of Novel Spiro and Condensed Indole Derivatives
title_full_unstemmed NiO Nanoparticles: An Efficient Catalyst for the Multicomponent One-Pot Synthesis of Novel Spiro and Condensed Indole Derivatives
title_short NiO Nanoparticles: An Efficient Catalyst for the Multicomponent One-Pot Synthesis of Novel Spiro and Condensed Indole Derivatives
title_sort nio nanoparticles an efficient catalyst for the multicomponent one pot synthesis of novel spiro and condensed indole derivatives
url http://dx.doi.org/10.1155/2013/606259
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