Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease

A wide number of natural molecules demonstrated neuroprotective effects on synaptic plasticity defects induced by amyloid-β (Aβ) in ex vivo and in vivo Alzheimer's disease (AD) models, suggesting a possible use in the treatment of this neurodegenerative disorder. However, several compounds, adm...

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Main Authors: Nunzia Maisto, Dalila Mango
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Pharmaceutical Analysis
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Online Access:http://www.sciencedirect.com/science/article/pii/S2095177924001540
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author Nunzia Maisto
Dalila Mango
author_facet Nunzia Maisto
Dalila Mango
author_sort Nunzia Maisto
collection DOAJ
description A wide number of natural molecules demonstrated neuroprotective effects on synaptic plasticity defects induced by amyloid-β (Aβ) in ex vivo and in vivo Alzheimer's disease (AD) models, suggesting a possible use in the treatment of this neurodegenerative disorder. However, several compounds, administered parenterally and orally, are unable to reach the brain due to the presence of the blood-brain barrier (BBB) which prevents the passage of external substances, such as proteins, peptides, or phytocompounds, representing a limit to the development of treatment for neurodegenerative diseases, such as AD. The combination of nano vesicular systems, as colloidal systems, and nose to brain (NtB) delivery depicts a new nanotechnological strategy to overtake this limit and to develop new treatment approaches for brain diseases, including the use of natural molecules in combination therapy for AD. Herein, we will provide an updated overview, examining the literature of the last 20 years and using specific keywords that provide evidence on natural products with the ability to restore synaptic plasticity alterations in AD models, and the possible application using safe and non-invasive strategies focusing on nano vesicular systems for NtB delivery.
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spelling doaj-art-cbfa53106347486484b3013fc41392ed2025-01-30T05:13:59ZengElsevierJournal of Pharmaceutical Analysis2095-17792024-12-011412101057Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's diseaseNunzia Maisto0Dalila Mango1Department of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, Rome, 00185, Italy; Laboratory of Neuropharmacology, EBRI Rita Levi-Montalcini Foundation, Rome, 00161, ItalyLaboratory of Neuropharmacology, EBRI Rita Levi-Montalcini Foundation, Rome, 00161, Italy; School of Pharmacy, Department of Biology, University of Rome Tor Vergata, Rome, 00133, Italy; Corresponding author. Laboratory of Neuropharmacology, EBRI Rita Levi-Montalcini Foundation, Rome, 00161, Italy.A wide number of natural molecules demonstrated neuroprotective effects on synaptic plasticity defects induced by amyloid-β (Aβ) in ex vivo and in vivo Alzheimer's disease (AD) models, suggesting a possible use in the treatment of this neurodegenerative disorder. However, several compounds, administered parenterally and orally, are unable to reach the brain due to the presence of the blood-brain barrier (BBB) which prevents the passage of external substances, such as proteins, peptides, or phytocompounds, representing a limit to the development of treatment for neurodegenerative diseases, such as AD. The combination of nano vesicular systems, as colloidal systems, and nose to brain (NtB) delivery depicts a new nanotechnological strategy to overtake this limit and to develop new treatment approaches for brain diseases, including the use of natural molecules in combination therapy for AD. Herein, we will provide an updated overview, examining the literature of the last 20 years and using specific keywords that provide evidence on natural products with the ability to restore synaptic plasticity alterations in AD models, and the possible application using safe and non-invasive strategies focusing on nano vesicular systems for NtB delivery.http://www.sciencedirect.com/science/article/pii/S2095177924001540Alzheimer's diseaseNanocarriersNatural compoundsNose to brain deliverySynaptic plasticity
spellingShingle Nunzia Maisto
Dalila Mango
Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease
Journal of Pharmaceutical Analysis
Alzheimer's disease
Nanocarriers
Natural compounds
Nose to brain delivery
Synaptic plasticity
title Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease
title_full Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease
title_fullStr Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease
title_full_unstemmed Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease
title_short Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease
title_sort nose to brain strategy coupled to nano vesicular system for natural products delivery focus on synaptic plasticity in alzheimer s disease
topic Alzheimer's disease
Nanocarriers
Natural compounds
Nose to brain delivery
Synaptic plasticity
url http://www.sciencedirect.com/science/article/pii/S2095177924001540
work_keys_str_mv AT nunziamaisto nosetobrainstrategycoupledtonanovesicularsystemfornaturalproductsdeliveryfocusonsynapticplasticityinalzheimersdisease
AT dalilamango nosetobrainstrategycoupledtonanovesicularsystemfornaturalproductsdeliveryfocusonsynapticplasticityinalzheimersdisease