Lack of Association between Promoter Gene Polymorphism (-318 C/T) and Multiple
Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system is believed to have a T cell-mediated autoimmune etiology. The cytotoxic T lymphocyte antigen 4 (CTLA-4) gene is a strong candidate for the involvement in autoimmune diseases. To examine the genetic a...
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| Format: | Article |
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| Language: | English |
| Published: |
University of Tehran
2008-04-01
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| Series: | Journal of Sciences, Islamic Republic of Iran |
| Online Access: | https://jsciences.ut.ac.ir/article_31087_c3f0f4294aae6114e5423337942687b3.pdf |
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| Summary: | Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system is believed to have a T cell-mediated autoimmune etiology. The cytotoxic T lymphocyte antigen 4 (CTLA-4) gene is a strong candidate for the involvement in autoimmune diseases. To examine the genetic association of the CTLA-4 gene locus with MS, in a case-control design, we analyzed (-318 C/T) single nucleotide polymorphism of the CTLA-4 gene in 135 unrelated Iranian relapsing-remitting MS patients and 135 age, gender and ethnicity-matched healthy subjects using PCR-RFLP method. The frequency of CTLA-4 gene (-318) polymorphism among cases and controls was 52.1% vs. 47.9% for CC, 39.2% vs. 60.8% for TC and 75.0% vs. 25% for TT genotypes respectively. The distribution of CTLA-4 (-318 C/T) genotype and allele frequencies did not significantly differ between MS patients and healthy subjects. In conclusion, there may not be any association between CTLA-4 gene (-318 T/C) polymorphism and MS development. |
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| ISSN: | 1016-1104 2345-6914 |