Expression of a cell death marker (clusterin) in muscle target fibers
We report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples fr...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
1993-09-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1993000300014&lng=en&tlng=en |
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| _version_ | 1850173038297874432 |
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| author | Acary Souza Bulle Oliveira Massimo Corbo Greg Duigou Alberto Alain Gabbai Arthur P. Hays |
| author_facet | Acary Souza Bulle Oliveira Massimo Corbo Greg Duigou Alberto Alain Gabbai Arthur P. Hays |
| author_sort | Acary Souza Bulle Oliveira |
| collection | DOAJ |
| description | We report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation. |
| format | Article |
| id | doaj-art-cbf68373b2ee41beb30ab1e8ed544576 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 1993-09-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-cbf68373b2ee41beb30ab1e8ed5445762025-08-20T02:19:57ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42271993-09-0151337137610.1590/S0004-282X1993000300014S0004-282X1993000300014Expression of a cell death marker (clusterin) in muscle target fibersAcary Souza Bulle Oliveira0Massimo CorboGreg Duigou1Alberto Alain Gabbai2Arthur P. HaysUniversidade Federal de São PauloColumbia UniversityUniversidade Federal de São PauloWe report, for the first time, the expression of immunoractivity to clusterin in skeletal muscle. Clusterin, a protein probably related to the process of programmed cell death (apoptosis), was specifically very highly expressed in target fibers. All target fibers found in 50 muscle biopsy samples from a variety of neuromuscular disorders expressed a high concentration of clusterin in the middle of the targets. Clusterin was not expressed in any targetoid fibers or cores. Acute denervation, where targets are mostly seen, may be the beginning of apoptosis. Hence our findings support the concept that targets are harbingers of acute denervation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1993000300014&lng=en&tlng=enmúsculo esqueléticofibras com «target»clusterina |
| spellingShingle | Acary Souza Bulle Oliveira Massimo Corbo Greg Duigou Alberto Alain Gabbai Arthur P. Hays Expression of a cell death marker (clusterin) in muscle target fibers Arquivos de Neuro-Psiquiatria músculo esquelético fibras com «target» clusterina |
| title | Expression of a cell death marker (clusterin) in muscle target fibers |
| title_full | Expression of a cell death marker (clusterin) in muscle target fibers |
| title_fullStr | Expression of a cell death marker (clusterin) in muscle target fibers |
| title_full_unstemmed | Expression of a cell death marker (clusterin) in muscle target fibers |
| title_short | Expression of a cell death marker (clusterin) in muscle target fibers |
| title_sort | expression of a cell death marker clusterin in muscle target fibers |
| topic | músculo esquelético fibras com «target» clusterina |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1993000300014&lng=en&tlng=en |
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