Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of <i>Leishmania amazonensis</i> Promastigotes and Intracellular Amastigotes
Caffeic acid phenethyl ester (CAPE) is a polyphenol produced by many plants and is found in red and green propolis. Here, we evaluated the antileishmanial activity of this natural product against <i>Leishmania amazonensis</i>. CAPE exhibited IC<sub>50</sub> values of 8.07 µM...
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MDPI AG
2025-04-01
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| author | Edson Roberto da Silva André Mesquita Claudia do Carmo Maquiaveli |
| author_facet | Edson Roberto da Silva André Mesquita Claudia do Carmo Maquiaveli |
| author_sort | Edson Roberto da Silva |
| collection | DOAJ |
| description | Caffeic acid phenethyl ester (CAPE) is a polyphenol produced by many plants and is found in red and green propolis. Here, we evaluated the antileishmanial activity of this natural product against <i>Leishmania amazonensis</i>. CAPE exhibited IC<sub>50</sub> values of 8.07 µM (95% CI, 6.79–9.62 µM) and 13.51 µM (95% CI, 10.71–17.16 µM) against <i>L. amazonensis</i> promastigotes and intracellular amastigotes, respectively. Additionally, CAPE inhibited <i>L. amazonensis</i> arginase in a non-competitive manner with a K<sub>i</sub> value of 1.51 ± 0.04 µM. These results highlight the potential of CAPE as a promising lead compound for developing new therapies against leishmaniasis. |
| format | Article |
| id | doaj-art-cbedaeec878d4a4d84328aa72f1a2fe2 |
| institution | DOAJ |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
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| series | Pathogens |
| spelling | doaj-art-cbedaeec878d4a4d84328aa72f1a2fe22025-08-20T03:13:50ZengMDPI AGPathogens2076-08172025-04-0114438410.3390/pathogens14040384Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of <i>Leishmania amazonensis</i> Promastigotes and Intracellular AmastigotesEdson Roberto da Silva0André Mesquita1Claudia do Carmo Maquiaveli2Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga 13635-900, SP, BrazilFaculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga 13635-900, SP, BrazilFaculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Pirassununga 13635-900, SP, BrazilCaffeic acid phenethyl ester (CAPE) is a polyphenol produced by many plants and is found in red and green propolis. Here, we evaluated the antileishmanial activity of this natural product against <i>Leishmania amazonensis</i>. CAPE exhibited IC<sub>50</sub> values of 8.07 µM (95% CI, 6.79–9.62 µM) and 13.51 µM (95% CI, 10.71–17.16 µM) against <i>L. amazonensis</i> promastigotes and intracellular amastigotes, respectively. Additionally, CAPE inhibited <i>L. amazonensis</i> arginase in a non-competitive manner with a K<sub>i</sub> value of 1.51 ± 0.04 µM. These results highlight the potential of CAPE as a promising lead compound for developing new therapies against leishmaniasis.https://www.mdpi.com/2076-0817/14/4/384antileishamanialsarginasecaffeic acidpolyaminescutaneous leishmaniasis |
| spellingShingle | Edson Roberto da Silva André Mesquita Claudia do Carmo Maquiaveli Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of <i>Leishmania amazonensis</i> Promastigotes and Intracellular Amastigotes Pathogens antileishamanials arginase caffeic acid polyamines cutaneous leishmaniasis |
| title | Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of <i>Leishmania amazonensis</i> Promastigotes and Intracellular Amastigotes |
| title_full | Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of <i>Leishmania amazonensis</i> Promastigotes and Intracellular Amastigotes |
| title_fullStr | Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of <i>Leishmania amazonensis</i> Promastigotes and Intracellular Amastigotes |
| title_full_unstemmed | Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of <i>Leishmania amazonensis</i> Promastigotes and Intracellular Amastigotes |
| title_short | Caffeic Acid Phenethyl Ester (CAPE) Inhibits Arginase Activity and Growth of <i>Leishmania amazonensis</i> Promastigotes and Intracellular Amastigotes |
| title_sort | caffeic acid phenethyl ester cape inhibits arginase activity and growth of i leishmania amazonensis i promastigotes and intracellular amastigotes |
| topic | antileishamanials arginase caffeic acid polyamines cutaneous leishmaniasis |
| url | https://www.mdpi.com/2076-0817/14/4/384 |
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