Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD
Abstract Cases of myelin oligodendrocyte glycoprotein (MOG) antibody‐associated disease (MOGAD) co‐occurring with neoplasms have been reported. In this international, retrospective cohort study in South Korea and the USA, 16 of 445 (3.6%) patients with MOGAD had concurrent neoplasm within 2 years of...
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Wiley
2025-04-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.52301 |
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| author | Young Nam Kwon Nanthaya Tisavipat Yong Guo Stephanie B. Syc‐Mazurek Ji Yeon Han Jun‐Soon Kim Kyomin Choi Seong‐il Oh Seok‐Jin Choi Eunhee Sohn Jeeyoung Oh Seung Woo Kim Ha Young Shin Byung Chan Lim Byoung Joon Kim Kyung Seok Park Jung‐Joon Sung Se Hoon Kim Sung‐Hye Park Anastasia Zekeridou Claudia F. Lucchinetti Sean J. Pittock John J. Chen Eoin P. Flanagan Sung‐Min Kim |
| author_facet | Young Nam Kwon Nanthaya Tisavipat Yong Guo Stephanie B. Syc‐Mazurek Ji Yeon Han Jun‐Soon Kim Kyomin Choi Seong‐il Oh Seok‐Jin Choi Eunhee Sohn Jeeyoung Oh Seung Woo Kim Ha Young Shin Byung Chan Lim Byoung Joon Kim Kyung Seok Park Jung‐Joon Sung Se Hoon Kim Sung‐Hye Park Anastasia Zekeridou Claudia F. Lucchinetti Sean J. Pittock John J. Chen Eoin P. Flanagan Sung‐Min Kim |
| author_sort | Young Nam Kwon |
| collection | DOAJ |
| description | Abstract Cases of myelin oligodendrocyte glycoprotein (MOG) antibody‐associated disease (MOGAD) co‐occurring with neoplasms have been reported. In this international, retrospective cohort study in South Korea and the USA, 16 of 445 (3.6%) patients with MOGAD had concurrent neoplasm within 2 years of MOGAD onset, resulting in a standardized incidence ratio for neoplasm of 3.10 (95% confidence interval [CI], 1.77–4.81; P < 0.001) when compared to the age‐ and country‐adjusted incidence of neoplasm in the general population. However, none of the nine tumor tissues obtained demonstrated MOG immunostaining. The slightly increased frequency without immunohistopathological evidence suggest with true paraneoplastic MOGAD is extremely rare. |
| format | Article |
| id | doaj-art-cbea951b227f429fad4efbd6a16495e3 |
| institution | OA Journals |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-cbea951b227f429fad4efbd6a16495e32025-08-20T02:20:12ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-04-0112486187010.1002/acn3.52301Assessment of concurrent neoplasms and a paraneoplastic association in MOGADYoung Nam Kwon0Nanthaya Tisavipat1Yong Guo2Stephanie B. Syc‐Mazurek3Ji Yeon Han4Jun‐Soon Kim5Kyomin Choi6Seong‐il Oh7Seok‐Jin Choi8Eunhee Sohn9Jeeyoung Oh10Seung Woo Kim11Ha Young Shin12Byung Chan Lim13Byoung Joon Kim14Kyung Seok Park15Jung‐Joon Sung16Se Hoon Kim17Sung‐Hye Park18Anastasia Zekeridou19Claudia F. Lucchinetti20Sean J. Pittock21John J. Chen22Eoin P. Flanagan23Sung‐Min Kim24Department of Neurology Severance Hospital, Yonsei University College of Medicine Seoul Republic of KoreaDepartment of Neurology Mayo Clinic Rochester Minnesota USADepartment of Neurology Mayo Clinic Rochester Minnesota USADepartment of Neurology Mayo Clinic Rochester Minnesota USADepartment of Pediatrics Inha University Hospital Incheon Republic of KoreaDepartment of Neurology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Republic of KoreaDepartment of Neurology Soonchunhyang University Cheonan Hospital Cheonan Republic of KoreaDepartment of Neurology Kyung Hee University Hospital, Kyung Hee University College of Medicine Seoul Republic of KoreaDepartment of Neurology Seoul National University Hospital, Seoul National University College of Medicine Seoul Republic of KoreaDepartment of Neurology Chungnam National University College of Medicine, Chungnam National University Hospital Daejeon Republic of KoreaDepartment of Neurology Konkuk University School of Medicine, Konkuk University Medical Center Seoul Republic of KoreaDepartment of Neurology Severance Hospital, Yonsei University College of Medicine Seoul Republic of KoreaDepartment of Neurology Severance Hospital, Yonsei University College of Medicine Seoul Republic of KoreaDepartment of Pediatrics Seoul National University College of Medicine, Seoul National University Children's Hospital Seoul Republic of KoreaDepartment of Neurology Samsung Medical Center, Sungkyunkwan University School of Medicine Seoul Republic of KoreaDepartment of Neurology Seoul National University Bundang Hospital, Seoul National University College of Medicine Seongnam Republic of KoreaDepartment of Neurology Seoul National University Hospital, Seoul National University College of Medicine Seoul Republic of KoreaDepartment of Pathology Severance Hospital, Yonsei University College of Medicine Seoul Republic of KoreaDepartment of Pathology Seoul National University Hospital, Seoul National University, College of Medicine Seoul Republic of KoreaDepartment of Neurology Mayo Clinic Rochester Minnesota USADepartment of Neurology Mayo Clinic Rochester Minnesota USADepartment of Neurology Mayo Clinic Rochester Minnesota USADepartment of Neurology Mayo Clinic Rochester Minnesota USADepartment of Neurology Mayo Clinic Rochester Minnesota USADepartment of Neurology Seoul National University Hospital, Seoul National University College of Medicine Seoul Republic of KoreaAbstract Cases of myelin oligodendrocyte glycoprotein (MOG) antibody‐associated disease (MOGAD) co‐occurring with neoplasms have been reported. In this international, retrospective cohort study in South Korea and the USA, 16 of 445 (3.6%) patients with MOGAD had concurrent neoplasm within 2 years of MOGAD onset, resulting in a standardized incidence ratio for neoplasm of 3.10 (95% confidence interval [CI], 1.77–4.81; P < 0.001) when compared to the age‐ and country‐adjusted incidence of neoplasm in the general population. However, none of the nine tumor tissues obtained demonstrated MOG immunostaining. The slightly increased frequency without immunohistopathological evidence suggest with true paraneoplastic MOGAD is extremely rare.https://doi.org/10.1002/acn3.52301 |
| spellingShingle | Young Nam Kwon Nanthaya Tisavipat Yong Guo Stephanie B. Syc‐Mazurek Ji Yeon Han Jun‐Soon Kim Kyomin Choi Seong‐il Oh Seok‐Jin Choi Eunhee Sohn Jeeyoung Oh Seung Woo Kim Ha Young Shin Byung Chan Lim Byoung Joon Kim Kyung Seok Park Jung‐Joon Sung Se Hoon Kim Sung‐Hye Park Anastasia Zekeridou Claudia F. Lucchinetti Sean J. Pittock John J. Chen Eoin P. Flanagan Sung‐Min Kim Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD Annals of Clinical and Translational Neurology |
| title | Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD |
| title_full | Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD |
| title_fullStr | Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD |
| title_full_unstemmed | Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD |
| title_short | Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD |
| title_sort | assessment of concurrent neoplasms and a paraneoplastic association in mogad |
| url | https://doi.org/10.1002/acn3.52301 |
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