Myeloproliferative Disease: An Unusual Cause of Raynaud’s Phenomenon and Digital Ischaemia
We describe a 59-year-old female who presented with ischaemic digits, preceded by a 6-month history of Raynaud’s phenomenon affecting her fingers and toes. There were no clinical or laboratory features of primary vasculitis or connective tissue disease, Doppler imaging was normal, and bloods were un...
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| Format: | Article |
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Wiley
2016-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/9675171 |
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| author | Celia Beynon Gwenan Huws Tom Lawson |
| author_facet | Celia Beynon Gwenan Huws Tom Lawson |
| author_sort | Celia Beynon |
| collection | DOAJ |
| description | We describe a 59-year-old female who presented with ischaemic digits, preceded by a 6-month history of Raynaud’s phenomenon affecting her fingers and toes. There were no clinical or laboratory features of primary vasculitis or connective tissue disease, Doppler imaging was normal, and bloods were unremarkable aside from a platelet count of 786 × 109/L (150–400) and white cells of 16 × 109/L (4–11). In view of the thrombocytosis a JAK2 mutation assay was requested which confirmed a JAK2 V617F mutation, suggesting essential thrombocytosis (ET) as the cause. She received treatment with hydroxycarbamide which normalised her platelet count and led to a complete resolution of her Raynaud’s symptoms. Raynaud’s phenomenon is a rare manifestation of ET. Myeloproliferative disorders such as ET should be considered in the differential diagnosis of Raynaud’s phenomenon and vasculitis. |
| format | Article |
| id | doaj-art-cbea837f7c98404cb6da2f7d2e0d98c2 |
| institution | DOAJ |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-cbea837f7c98404cb6da2f7d2e0d98c22025-08-20T03:04:42ZengWileyCase Reports in Medicine1687-96271687-96352016-01-01201610.1155/2016/96751719675171Myeloproliferative Disease: An Unusual Cause of Raynaud’s Phenomenon and Digital IschaemiaCelia Beynon0Gwenan Huws1Tom Lawson2Department of Rheumatology, Princess of Wales Hospital, Coity Road, Bridgend CF31 1RQ, UKDepartment of Rheumatology, Royal Gwent Hospital, Cardiff Road, Newport NP20 2UB, UKDepartment of Rheumatology, Princess of Wales Hospital, Coity Road, Bridgend CF31 1RQ, UKWe describe a 59-year-old female who presented with ischaemic digits, preceded by a 6-month history of Raynaud’s phenomenon affecting her fingers and toes. There were no clinical or laboratory features of primary vasculitis or connective tissue disease, Doppler imaging was normal, and bloods were unremarkable aside from a platelet count of 786 × 109/L (150–400) and white cells of 16 × 109/L (4–11). In view of the thrombocytosis a JAK2 mutation assay was requested which confirmed a JAK2 V617F mutation, suggesting essential thrombocytosis (ET) as the cause. She received treatment with hydroxycarbamide which normalised her platelet count and led to a complete resolution of her Raynaud’s symptoms. Raynaud’s phenomenon is a rare manifestation of ET. Myeloproliferative disorders such as ET should be considered in the differential diagnosis of Raynaud’s phenomenon and vasculitis.http://dx.doi.org/10.1155/2016/9675171 |
| spellingShingle | Celia Beynon Gwenan Huws Tom Lawson Myeloproliferative Disease: An Unusual Cause of Raynaud’s Phenomenon and Digital Ischaemia Case Reports in Medicine |
| title | Myeloproliferative Disease: An Unusual Cause of Raynaud’s Phenomenon and Digital Ischaemia |
| title_full | Myeloproliferative Disease: An Unusual Cause of Raynaud’s Phenomenon and Digital Ischaemia |
| title_fullStr | Myeloproliferative Disease: An Unusual Cause of Raynaud’s Phenomenon and Digital Ischaemia |
| title_full_unstemmed | Myeloproliferative Disease: An Unusual Cause of Raynaud’s Phenomenon and Digital Ischaemia |
| title_short | Myeloproliferative Disease: An Unusual Cause of Raynaud’s Phenomenon and Digital Ischaemia |
| title_sort | myeloproliferative disease an unusual cause of raynaud s phenomenon and digital ischaemia |
| url | http://dx.doi.org/10.1155/2016/9675171 |
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