Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts
ABSTRACT Deficiency of the myocardial microcirculation plays a role in the pathogenesis of heart failure (HF). We aimed to investigate the association of myocardial blood flow (MBF) and the retinal microvasculature with left ventricular (LV) function and its potential mediators. In healthy controls...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.70087 |
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| author | Jia Liu Chang Chen Zhongping Yu Xuwei Chen Zihao Chen Wei Li Min Ye Xin He Jiangui He Juping Liu Yugang Dong Jan A. Staessen Chen Liu Fengjuan Yao Fang‐Fei Wei |
| author_facet | Jia Liu Chang Chen Zhongping Yu Xuwei Chen Zihao Chen Wei Li Min Ye Xin He Jiangui He Juping Liu Yugang Dong Jan A. Staessen Chen Liu Fengjuan Yao Fang‐Fei Wei |
| author_sort | Jia Liu |
| collection | DOAJ |
| description | ABSTRACT Deficiency of the myocardial microcirculation plays a role in the pathogenesis of heart failure (HF). We aimed to investigate the association of myocardial blood flow (MBF) and the retinal microvasculature with left ventricular (LV) function and its potential mediators. In healthy controls (HCs; n = 48), patients with cardiovascular risk factors (CVRF; n = 49) and patients with compensated HF (CHF; n = 52), we assessed LV diastolic filling pressure (E/e′), LV ejection fraction (LVEF), and global longitudinal strain (GLS) associated with MBF and the retinal arteriole‐to‐venule ratio (AVR), using multivariable regression models, while considering their direct contributions to LV function and the indirect contributions running via NT‐proBNP. Compared with HC, CHF had lower MBF and smaller AVR (p ≤ 0.002). In all participants, smaller AVR was associated with higher E/e′, lower LVEF, and lower GLS (p ≤ 0.010). Per 1 dB × dB/s MBF reduction, E/e′ increased by 0.09, whereas LVEF and GLS decreased by 0.46% and 0.14%, respectively (p < 0.001). The indirect contributions running via NT‐proBNP were all significant (p < 0.001) for MBF and for AVR related to GLS (p = 0.044) with mediation proportions of ≥29%. Across subgroups, these associations were directionally similar but lost significance given the lower sample size. Furthermore, across the spectrum of LV function, estimates of the associations of MBF with E/e′ and AVR with GLS showed a decreasing versus increasing trend (p ≤ 0.034). MBF and retinal microvasculature were associated with LV function and counterbalance the impaired LV function in CHF. NT‐proBNP, the natural vasodilating and natriuretic hormone, contributes close to 30% of the maintenance of LV function. |
| format | Article |
| id | doaj-art-cbe8b064090b41c5b3219f062dd74bdf |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-cbe8b064090b41c5b3219f062dd74bdf2025-08-20T03:34:44ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-06-01276n/an/a10.1111/jch.70087Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing HeartsJia Liu0Chang Chen1Zhongping Yu2Xuwei Chen3Zihao Chen4Wei Li5Min Ye6Xin He7Jiangui He8Juping Liu9Yugang Dong10Jan A. Staessen11Chen Liu12Fengjuan Yao13Fang‐Fei Wei14Department of Cardiology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Cardiology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Cardiology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Cardiology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Cardiology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Medical Ultrasonics Institute for Diagnostic and Interventional Ultrasound The First Affiliated Hospital of Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Cardiology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Cardiology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Cardiology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaTianjin Key Laboratory of Retinal Functions and Diseases Tianjin Branch of National Clinical Research Center for Ocular Disease Eye Institute and School of Optometry Tianjin Medical University Eye Hospital Tianjin ChinaDepartment of Cardiology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaNon‐Profit Research Institute Alliance for the Promotion of Preventive Medicine Mechelen BelgiumDepartment of Cardiology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Medical Ultrasonics Institute for Diagnostic and Interventional Ultrasound The First Affiliated Hospital of Sun Yat‐sen University Guangzhou Guangdong ChinaDepartment of Cardiology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong ChinaABSTRACT Deficiency of the myocardial microcirculation plays a role in the pathogenesis of heart failure (HF). We aimed to investigate the association of myocardial blood flow (MBF) and the retinal microvasculature with left ventricular (LV) function and its potential mediators. In healthy controls (HCs; n = 48), patients with cardiovascular risk factors (CVRF; n = 49) and patients with compensated HF (CHF; n = 52), we assessed LV diastolic filling pressure (E/e′), LV ejection fraction (LVEF), and global longitudinal strain (GLS) associated with MBF and the retinal arteriole‐to‐venule ratio (AVR), using multivariable regression models, while considering their direct contributions to LV function and the indirect contributions running via NT‐proBNP. Compared with HC, CHF had lower MBF and smaller AVR (p ≤ 0.002). In all participants, smaller AVR was associated with higher E/e′, lower LVEF, and lower GLS (p ≤ 0.010). Per 1 dB × dB/s MBF reduction, E/e′ increased by 0.09, whereas LVEF and GLS decreased by 0.46% and 0.14%, respectively (p < 0.001). The indirect contributions running via NT‐proBNP were all significant (p < 0.001) for MBF and for AVR related to GLS (p = 0.044) with mediation proportions of ≥29%. Across subgroups, these associations were directionally similar but lost significance given the lower sample size. Furthermore, across the spectrum of LV function, estimates of the associations of MBF with E/e′ and AVR with GLS showed a decreasing versus increasing trend (p ≤ 0.034). MBF and retinal microvasculature were associated with LV function and counterbalance the impaired LV function in CHF. NT‐proBNP, the natural vasodilating and natriuretic hormone, contributes close to 30% of the maintenance of LV function.https://doi.org/10.1111/jch.70087echocardiographyheart failuremyocardial blood flowretinal microvasculature |
| spellingShingle | Jia Liu Chang Chen Zhongping Yu Xuwei Chen Zihao Chen Wei Li Min Ye Xin He Jiangui He Juping Liu Yugang Dong Jan A. Staessen Chen Liu Fengjuan Yao Fang‐Fei Wei Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts The Journal of Clinical Hypertension echocardiography heart failure myocardial blood flow retinal microvasculature |
| title | Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts |
| title_full | Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts |
| title_fullStr | Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts |
| title_full_unstemmed | Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts |
| title_short | Myocardial Blood Flow and the Retinal Microvasculature Across the Spectrum From Normal to Failing Hearts |
| title_sort | myocardial blood flow and the retinal microvasculature across the spectrum from normal to failing hearts |
| topic | echocardiography heart failure myocardial blood flow retinal microvasculature |
| url | https://doi.org/10.1111/jch.70087 |
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