Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study
Abstract BackgroundDigital phenotyping—the use of digital data to measure and understand behavior and internal states—shows promise for advancing predictive analytics in mental health, particularly when combined with other data sources. However, linking digital phenotyping dat...
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JMIR Publications
2025-06-01
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| Series: | JMIR Formative Research |
| Online Access: | https://formative.jmir.org/2025/1/e71377 |
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| author | Joanne R Beames Omar Dabash Michael J Spoelma Artur Shvetcov Wu Yi Zheng Aimy Slade Jin Han Leonard Hoon Joost Funke Kupper Richard Parker Brittany Mitchell Nicholas G Martin Jill M Newby Alexis E Whitton Helen Christensen |
| author_facet | Joanne R Beames Omar Dabash Michael J Spoelma Artur Shvetcov Wu Yi Zheng Aimy Slade Jin Han Leonard Hoon Joost Funke Kupper Richard Parker Brittany Mitchell Nicholas G Martin Jill M Newby Alexis E Whitton Helen Christensen |
| author_sort | Joanne R Beames |
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Abstract
BackgroundDigital phenotyping—the use of digital data to measure and understand behavior and internal states—shows promise for advancing predictive analytics in mental health, particularly when combined with other data sources. However, linking digital phenotyping data with sources of highly sensitive clinical or genetic data remains rare, primarily due to technical, ethical, and procedural challenges. Understanding the feasibility of collecting and linking these data types is a critical first step toward developing novel multimodal datasets.
ObjectiveThe Mobigene Pilot Study examines the feasibility of collecting smartphone-based digital phenotyping and mental health data and linking it to genetic data from an existing cohort of adults with a history of depression (ie, the Australian Genetics of Depression Study). This paper aims to describe (1) rates of study uptake and adherence; (2) levels of adherence and engagement with daily mood assessments; (3) willingness to take part in similar research; and (4) whether feasibility indicators varied according to mental health symptoms.
MethodsParticipants aged 18‐30 years with genetic data from the Australian Genetics of Depression Study were invited to participate in a two-week digital phenotyping study. They completed a baseline mental health survey and then downloaded the MindGRID digital phenotyping app. Active data from cognitive, voice, and typing tasks were collected once per day on days 1 and 11. Daily momentary assessments of self-reported mood were collected on days 2‐10 (once per day for 9 days). Passive data (eg, from GPS, accelerometers) were collected throughout the two-week period. A second mental health survey was then completed after two weeks. To measure feasibility, we examined metrics of study uptake (eg, consent) and adherence (eg, proportion of completed momentary assessments), and willingness to participate in similar future research. Pearson correlations and t
ResultsOf 174 consenting and eligible participants, 153 (87.9%) completed the baseline mental health survey and 126 (72.4%) provided data enabling linkage of genetic, self-report, and digital data. After removal of duplicates, we found that 100 (57.5%) of these identified as unique participants and 69 (39.7%) provided complete post-study data. A small proportion of participants dropped out prior to completing the baseline survey (21/174, 12.1%) or during app-based data collection (31/174, 17.8%). Participants completed an average of 5.30 (SD 2.76) daily mood assessments. All 69 (100%) participants who completed the post-study surveys expressed willingness to participate in similar studies in the future. There was no significant association between feasibility indicators and current mental health symptoms.
ConclusionsIt is feasible to collect and link multimodal datasets involving digital phenotyping, clinical, and genetic data, although there are some methodological and technical challenges. We provide recommendations for future research related to data collection platforms and compliance. |
| format | Article |
| id | doaj-art-cbe30ed9d37d48bf83eea7fe9c261cdd |
| institution | Kabale University |
| issn | 2561-326X |
| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-cbe30ed9d37d48bf83eea7fe9c261cdd2025-08-20T03:30:03ZengJMIR PublicationsJMIR Formative Research2561-326X2025-06-019e71377e7137710.2196/71377Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational StudyJoanne R Beameshttp://orcid.org/0000-0003-3630-0980Omar Dabashhttp://orcid.org/0000-0003-2495-9286Michael J Spoelmahttp://orcid.org/0000-0003-2844-0748Artur Shvetcovhttp://orcid.org/0000-0003-0592-984XWu Yi Zhenghttp://orcid.org/0000-0002-1159-4700Aimy Sladehttp://orcid.org/0000-0001-5368-1792Jin Hanhttp://orcid.org/0000-0001-7624-9468Leonard Hoonhttp://orcid.org/0000-0003-0428-7240Joost Funke Kupperhttp://orcid.org/0009-0009-6067-1782Richard Parkerhttp://orcid.org/0000-0003-1451-5622Brittany Mitchellhttp://orcid.org/0000-0002-9050-1516Nicholas G Martinhttp://orcid.org/0000-0003-4069-8020Jill M Newbyhttp://orcid.org/0000-0002-6473-9811Alexis E Whittonhttp://orcid.org/0000-0002-7944-2172Helen Christensenhttp://orcid.org/0000-0003-0435-2065 Abstract BackgroundDigital phenotyping—the use of digital data to measure and understand behavior and internal states—shows promise for advancing predictive analytics in mental health, particularly when combined with other data sources. However, linking digital phenotyping data with sources of highly sensitive clinical or genetic data remains rare, primarily due to technical, ethical, and procedural challenges. Understanding the feasibility of collecting and linking these data types is a critical first step toward developing novel multimodal datasets. ObjectiveThe Mobigene Pilot Study examines the feasibility of collecting smartphone-based digital phenotyping and mental health data and linking it to genetic data from an existing cohort of adults with a history of depression (ie, the Australian Genetics of Depression Study). This paper aims to describe (1) rates of study uptake and adherence; (2) levels of adherence and engagement with daily mood assessments; (3) willingness to take part in similar research; and (4) whether feasibility indicators varied according to mental health symptoms. MethodsParticipants aged 18‐30 years with genetic data from the Australian Genetics of Depression Study were invited to participate in a two-week digital phenotyping study. They completed a baseline mental health survey and then downloaded the MindGRID digital phenotyping app. Active data from cognitive, voice, and typing tasks were collected once per day on days 1 and 11. Daily momentary assessments of self-reported mood were collected on days 2‐10 (once per day for 9 days). Passive data (eg, from GPS, accelerometers) were collected throughout the two-week period. A second mental health survey was then completed after two weeks. To measure feasibility, we examined metrics of study uptake (eg, consent) and adherence (eg, proportion of completed momentary assessments), and willingness to participate in similar future research. Pearson correlations and t ResultsOf 174 consenting and eligible participants, 153 (87.9%) completed the baseline mental health survey and 126 (72.4%) provided data enabling linkage of genetic, self-report, and digital data. After removal of duplicates, we found that 100 (57.5%) of these identified as unique participants and 69 (39.7%) provided complete post-study data. A small proportion of participants dropped out prior to completing the baseline survey (21/174, 12.1%) or during app-based data collection (31/174, 17.8%). Participants completed an average of 5.30 (SD 2.76) daily mood assessments. All 69 (100%) participants who completed the post-study surveys expressed willingness to participate in similar studies in the future. There was no significant association between feasibility indicators and current mental health symptoms. ConclusionsIt is feasible to collect and link multimodal datasets involving digital phenotyping, clinical, and genetic data, although there are some methodological and technical challenges. We provide recommendations for future research related to data collection platforms and compliance.https://formative.jmir.org/2025/1/e71377 |
| spellingShingle | Joanne R Beames Omar Dabash Michael J Spoelma Artur Shvetcov Wu Yi Zheng Aimy Slade Jin Han Leonard Hoon Joost Funke Kupper Richard Parker Brittany Mitchell Nicholas G Martin Jill M Newby Alexis E Whitton Helen Christensen Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study JMIR Formative Research |
| title | Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study |
| title_full | Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study |
| title_fullStr | Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study |
| title_full_unstemmed | Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study |
| title_short | Feasibility of Collecting and Linking Digital Phenotyping, Clinical, and Genetics Data for Mental Health Research: Pilot Observational Study |
| title_sort | feasibility of collecting and linking digital phenotyping clinical and genetics data for mental health research pilot observational study |
| url | https://formative.jmir.org/2025/1/e71377 |
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