Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study
Objective(s): Gelatin / Sodium Alginate Thymus kotschyanus (GE/SA T. kotschyanus) hydrogel was prepared for use as a wound healing.Materials and Methods: The hydrogel was prepared by casting and cross-linking method and the physicochemical and the antimicrobial properties of the hydrogels were deter...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2025-07-01
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| Series: | Nanomedicine Journal |
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| Online Access: | https://nmj.mums.ac.ir/article_25632_9510dff7d8e67a56480907b98327caaa.pdf |
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| author | Hadi Hossainpour Hosna Alvandi Ramin Abiri Faranak Aghaz Amirhooshang Alvandi Elham Arkan |
| author_facet | Hadi Hossainpour Hosna Alvandi Ramin Abiri Faranak Aghaz Amirhooshang Alvandi Elham Arkan |
| author_sort | Hadi Hossainpour |
| collection | DOAJ |
| description | Objective(s): Gelatin / Sodium Alginate Thymus kotschyanus (GE/SA T. kotschyanus) hydrogel was prepared for use as a wound healing.Materials and Methods: The hydrogel was prepared by casting and cross-linking method and the physicochemical and the antimicrobial properties of the hydrogels were determined.Results: The GE/SA hydrogel showed high mechanical properties, while the addition of the extract to the hydrogel led to the relaxation of the polymer network and thus increased the elasticity of the dressing, and it had a good biodegradation. The compatibility of hydrogels with fibroblast cells was confirmed by MTT assay. Also, GE/SA T. kotschyanus hydrogels were found to be excellent Hemocompatibile. Moreover, these hydrogels exhibited the antibacterial activity against Pseudomonas aeruginosa, and Escherichia coli. In addition, these hydrogels showed the best antifungal effect against Candida albicans.Conclusion: The GE/SA T. kotschyanus hydrogels had the potential for use in wound dressing. |
| format | Article |
| id | doaj-art-cbdc5065052e4b7b912532439f1bb36f |
| institution | DOAJ |
| issn | 2322-3049 2322-5904 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Nanomedicine Journal |
| spelling | doaj-art-cbdc5065052e4b7b912532439f1bb36f2025-08-20T03:08:40ZengMashhad University of Medical SciencesNanomedicine Journal2322-30492322-59042025-07-0112344345310.22038/nmj.2025.83422.208825632Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro studyHadi Hossainpour0Hosna Alvandi1Ramin Abiri2Faranak Aghaz3Amirhooshang Alvandi4Elham Arkan5Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IranNano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IranNano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, IranDepartment of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, IranNano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, IranObjective(s): Gelatin / Sodium Alginate Thymus kotschyanus (GE/SA T. kotschyanus) hydrogel was prepared for use as a wound healing.Materials and Methods: The hydrogel was prepared by casting and cross-linking method and the physicochemical and the antimicrobial properties of the hydrogels were determined.Results: The GE/SA hydrogel showed high mechanical properties, while the addition of the extract to the hydrogel led to the relaxation of the polymer network and thus increased the elasticity of the dressing, and it had a good biodegradation. The compatibility of hydrogels with fibroblast cells was confirmed by MTT assay. Also, GE/SA T. kotschyanus hydrogels were found to be excellent Hemocompatibile. Moreover, these hydrogels exhibited the antibacterial activity against Pseudomonas aeruginosa, and Escherichia coli. In addition, these hydrogels showed the best antifungal effect against Candida albicans.Conclusion: The GE/SA T. kotschyanus hydrogels had the potential for use in wound dressing.https://nmj.mums.ac.ir/article_25632_9510dff7d8e67a56480907b98327caaa.pdfhydrogelgelatinsodium alginatethymus kotschyanuswound healing |
| spellingShingle | Hadi Hossainpour Hosna Alvandi Ramin Abiri Faranak Aghaz Amirhooshang Alvandi Elham Arkan Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study Nanomedicine Journal hydrogel gelatin sodium alginate thymus kotschyanus wound healing |
| title | Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study |
| title_full | Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study |
| title_fullStr | Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study |
| title_full_unstemmed | Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study |
| title_short | Preparation and characterization of gelatin/ sodium alginate with thymus Kotschyanus hydrogel for wound healing, In Vitro study |
| title_sort | preparation and characterization of gelatin sodium alginate with thymus kotschyanus hydrogel for wound healing in vitro study |
| topic | hydrogel gelatin sodium alginate thymus kotschyanus wound healing |
| url | https://nmj.mums.ac.ir/article_25632_9510dff7d8e67a56480907b98327caaa.pdf |
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