Regulation of the tuft cell-ILC2 circuit in intestinal mucosal immunity

Regulation of the tuft cell-ILC2 circuit in intestinal mucosal immunity

The intestinal mucosal immune system maintains homeostasis through complex interactions between epithelial cells and innate lymphoid cells in the lamina propria. Tuft cells, previously overlooked intestinal epithelial cell types, detect parasites and metabolites via Sucnr1 and TAS2R receptors. They...

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Bibliographic Details
Main Authors: Kaiyu Shang, Xinxin Qi, Tingting Tian, Huidong Shi, Yuejie Zhu, Fengbo Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
tuft cells
mucosal immunity
intestinal homeostasis
inflammatory bowel disease
tuft cell-ILC2 circuit
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1568062/full
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