A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in Children
Introduction. Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of Aloe vera cream and Calendula officinalis ointment on the frequency and severity of DD in chi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/810234 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558064051421184 |
|---|---|
| author | Yunes Panahi Mohamad Reza Sharif Alireza Sharif Fatemeh Beiraghdar Zahra Zahiri Golnoush Amirchoopani Eisa Tahmasbpour Marzony Amirhossein Sahebkar |
| author_facet | Yunes Panahi Mohamad Reza Sharif Alireza Sharif Fatemeh Beiraghdar Zahra Zahiri Golnoush Amirchoopani Eisa Tahmasbpour Marzony Amirhossein Sahebkar |
| author_sort | Yunes Panahi |
| collection | DOAJ |
| description | Introduction. Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of Aloe vera cream and Calendula officinalis ointment on the frequency and severity of DD in children. Methods. Sixty-six infants with DD (aged < 3 years) were randomized to receive either Aloe cream (n=32) or Calendula ointment (n=34). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial. Results. Although improvement in the severity of DD was observed in both treatment groups (P<0.001), patients receiving Calendula ointment had significantly fewer rash sites compared to Aloe group (P=0.001). No adverse effect was reported from either of the medications. Discussion. The evidence from this study suggests that topical Aloe and in particular Calendula could serve as safe and effective treatment for the treatment of diaper dermatitis in infants. |
| format | Article |
| id | doaj-art-cbc8f96a1daf4c80beb5f1d498c90ccd |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-cbc8f96a1daf4c80beb5f1d498c90ccd2025-02-03T01:33:26ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/810234810234A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in ChildrenYunes Panahi0Mohamad Reza Sharif1Alireza Sharif2Fatemeh Beiraghdar3Zahra Zahiri4Golnoush Amirchoopani5Eisa Tahmasbpour Marzony6Amirhossein Sahebkar7Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19945-581, Tehran, IranDepartment of Pediatrics, Kashan University of Medical Sciences, P.O. Box 88175-111, Kashan, IranDepartment of Infectious Diseases, Kashan University of Medical Sciences, P.O. Box 88175-111, Kashan, IranNephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19945-581, Tehran, IranPharmaceutical Sciences Branch, Islamic Azad University, P.O. Box 19945-581, Tehran, IranChemical Injuries Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19945-581, Tehran, IranChemical Injuries Research Center, Baqiyatallah University of Medical Sciences, P.O. Box 19945-581, Tehran, IranBiotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences (MUMS), P.O. Box 91775-1365, Mashhad, IranIntroduction. Diaper dermatitis (DD) is a common inflammatory disorder among children and infants. The objective of the present randomized and double-blind trial was to compare the therapeutic efficacies of Aloe vera cream and Calendula officinalis ointment on the frequency and severity of DD in children. Methods. Sixty-six infants with DD (aged < 3 years) were randomized to receive either Aloe cream (n=32) or Calendula ointment (n=34). Infants were treated with these drugs 3 times a day for 10 days. The severity of dermatitis was graded at baseline as well as at the end of trial using a 5-point scale. The adverse effects of study medications were assessed during the trial. Results. Although improvement in the severity of DD was observed in both treatment groups (P<0.001), patients receiving Calendula ointment had significantly fewer rash sites compared to Aloe group (P=0.001). No adverse effect was reported from either of the medications. Discussion. The evidence from this study suggests that topical Aloe and in particular Calendula could serve as safe and effective treatment for the treatment of diaper dermatitis in infants.http://dx.doi.org/10.1100/2012/810234 |
| spellingShingle | Yunes Panahi Mohamad Reza Sharif Alireza Sharif Fatemeh Beiraghdar Zahra Zahiri Golnoush Amirchoopani Eisa Tahmasbpour Marzony Amirhossein Sahebkar A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in Children The Scientific World Journal |
| title | A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in Children |
| title_full | A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in Children |
| title_fullStr | A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in Children |
| title_full_unstemmed | A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in Children |
| title_short | A Randomized Comparative Trial on the Therapeutic Efficacy of Topical Aloe vera and Calendula officinalis on Diaper Dermatitis in Children |
| title_sort | randomized comparative trial on the therapeutic efficacy of topical aloe vera and calendula officinalis on diaper dermatitis in children |
| url | http://dx.doi.org/10.1100/2012/810234 |
| work_keys_str_mv | AT yunespanahi arandomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT mohamadrezasharif arandomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT alirezasharif arandomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT fatemehbeiraghdar arandomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT zahrazahiri arandomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT golnoushamirchoopani arandomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT eisatahmasbpourmarzony arandomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT amirhosseinsahebkar arandomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT yunespanahi randomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT mohamadrezasharif randomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT alirezasharif randomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT fatemehbeiraghdar randomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT zahrazahiri randomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT golnoushamirchoopani randomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT eisatahmasbpourmarzony randomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren AT amirhosseinsahebkar randomizedcomparativetrialonthetherapeuticefficacyoftopicalaloeveraandcalendulaofficinalisondiaperdermatitisinchildren |