Disparities in Colorectal Cancer Incidence Trends Among Hispanics Living in Puerto Rico (2000–2021): A Comparison With Surveillance, Epidemiology, and End Results (SEER) Database
ABSTRACT Background Although the overall colorectal cancer (CRC) incidence has been steadily declining in the United States, a dramatic increase in the number of CRC cases among individuals younger than 50 years of age (early‐onset CRC) has been observed. CRC is the second and first leading cause of...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70851 |
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| author | Luis D. Borrero‐Garcia Marilyn Moró‐Carrión Carlos R. Torres‐Cintrón Hilmaris Centeno‐Girona Victoria Perez Taymaraliz Santos‐Colón María González‐Pons |
| author_facet | Luis D. Borrero‐Garcia Marilyn Moró‐Carrión Carlos R. Torres‐Cintrón Hilmaris Centeno‐Girona Victoria Perez Taymaraliz Santos‐Colón María González‐Pons |
| author_sort | Luis D. Borrero‐Garcia |
| collection | DOAJ |
| description | ABSTRACT Background Although the overall colorectal cancer (CRC) incidence has been steadily declining in the United States, a dramatic increase in the number of CRC cases among individuals younger than 50 years of age (early‐onset CRC) has been observed. CRC is the second and first leading cause of cancer death in the United States and among Hispanic men and women living in Puerto Rico (PRH), respectively. We report CRC incidence rates from 2000 to 2021 among PRH and compare them to data in the Surveillance, Epidemiology, and End Results Program (SEER). Methods Data on colorectal adenocarcinomas diagnosed between January 1, 2000, and December 31, 2021, were obtained from the Puerto Rico Central Cancer Registry and SEER17, including race and ethnicity. Age‐standardized incidence rates were calculated using the direct method. The Joinpoint Regression Program calculated temporal trends on CRC incidence rates based on age‐adjusted Average Annual Percent Change (AAPC) estimates. Results A total of 729,479 incident cases of CRC were analyzed. US Hispanics had the highest percentage of early‐onset CRC (EOCRC) cases (17.0%) among the racial and ethnic groups studied. PRH had the highest age‐standardized EOCRC incidence rate (12.18 per 100,000 persons) and the highest increase in EOCRC incidence temporal trends (AAPC = 2.68; 95% CI: 1.83 to 3.51). Conclusions A significantly higher increase in EOCRC incidence was observed among Hispanic populations. Future studies should disaggregate Hispanic subpopulations by considering the country of ancestral origin, which will help identify specific risk factors and exposures and aid in developing tailored prevention and risk stratification strategies to reduce EOCRC incidence. |
| format | Article |
| id | doaj-art-cbc86dad11c846d3b6c146d8632b3dc2 |
| institution | OA Journals |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-cbc86dad11c846d3b6c146d8632b3dc22025-08-20T02:18:36ZengWileyCancer Medicine2045-76342025-04-01148n/an/a10.1002/cam4.70851Disparities in Colorectal Cancer Incidence Trends Among Hispanics Living in Puerto Rico (2000–2021): A Comparison With Surveillance, Epidemiology, and End Results (SEER) DatabaseLuis D. Borrero‐Garcia0Marilyn Moró‐Carrión1Carlos R. Torres‐Cintrón2Hilmaris Centeno‐Girona3Victoria Perez4Taymaraliz Santos‐Colón5María González‐Pons6Division of Clinical and Translational Cancer Research University of Puerto Rico Comprehensive Cancer Center San Juan Puerto RicoDivision of Clinical and Translational Cancer Research University of Puerto Rico Comprehensive Cancer Center San Juan Puerto RicoPuerto Rico Central Cancer Registry San Juan Puerto RicoDivision of Clinical and Translational Cancer Research University of Puerto Rico Comprehensive Cancer Center San Juan Puerto RicoSchool of Public Health University of Texas Health Science Center Houston Dallas Texas USASchool of Public Health University of Puerto Rico Medical Sciences Campus San Juan Puerto RicoDivision of Clinical and Translational Cancer Research University of Puerto Rico Comprehensive Cancer Center San Juan Puerto RicoABSTRACT Background Although the overall colorectal cancer (CRC) incidence has been steadily declining in the United States, a dramatic increase in the number of CRC cases among individuals younger than 50 years of age (early‐onset CRC) has been observed. CRC is the second and first leading cause of cancer death in the United States and among Hispanic men and women living in Puerto Rico (PRH), respectively. We report CRC incidence rates from 2000 to 2021 among PRH and compare them to data in the Surveillance, Epidemiology, and End Results Program (SEER). Methods Data on colorectal adenocarcinomas diagnosed between January 1, 2000, and December 31, 2021, were obtained from the Puerto Rico Central Cancer Registry and SEER17, including race and ethnicity. Age‐standardized incidence rates were calculated using the direct method. The Joinpoint Regression Program calculated temporal trends on CRC incidence rates based on age‐adjusted Average Annual Percent Change (AAPC) estimates. Results A total of 729,479 incident cases of CRC were analyzed. US Hispanics had the highest percentage of early‐onset CRC (EOCRC) cases (17.0%) among the racial and ethnic groups studied. PRH had the highest age‐standardized EOCRC incidence rate (12.18 per 100,000 persons) and the highest increase in EOCRC incidence temporal trends (AAPC = 2.68; 95% CI: 1.83 to 3.51). Conclusions A significantly higher increase in EOCRC incidence was observed among Hispanic populations. Future studies should disaggregate Hispanic subpopulations by considering the country of ancestral origin, which will help identify specific risk factors and exposures and aid in developing tailored prevention and risk stratification strategies to reduce EOCRC incidence.https://doi.org/10.1002/cam4.70851colorectal cancerdisparitiesearly‐onset colorectal cancerHispanicracial and ethnic |
| spellingShingle | Luis D. Borrero‐Garcia Marilyn Moró‐Carrión Carlos R. Torres‐Cintrón Hilmaris Centeno‐Girona Victoria Perez Taymaraliz Santos‐Colón María González‐Pons Disparities in Colorectal Cancer Incidence Trends Among Hispanics Living in Puerto Rico (2000–2021): A Comparison With Surveillance, Epidemiology, and End Results (SEER) Database Cancer Medicine colorectal cancer disparities early‐onset colorectal cancer Hispanic racial and ethnic |
| title | Disparities in Colorectal Cancer Incidence Trends Among Hispanics Living in Puerto Rico (2000–2021): A Comparison With Surveillance, Epidemiology, and End Results (SEER) Database |
| title_full | Disparities in Colorectal Cancer Incidence Trends Among Hispanics Living in Puerto Rico (2000–2021): A Comparison With Surveillance, Epidemiology, and End Results (SEER) Database |
| title_fullStr | Disparities in Colorectal Cancer Incidence Trends Among Hispanics Living in Puerto Rico (2000–2021): A Comparison With Surveillance, Epidemiology, and End Results (SEER) Database |
| title_full_unstemmed | Disparities in Colorectal Cancer Incidence Trends Among Hispanics Living in Puerto Rico (2000–2021): A Comparison With Surveillance, Epidemiology, and End Results (SEER) Database |
| title_short | Disparities in Colorectal Cancer Incidence Trends Among Hispanics Living in Puerto Rico (2000–2021): A Comparison With Surveillance, Epidemiology, and End Results (SEER) Database |
| title_sort | disparities in colorectal cancer incidence trends among hispanics living in puerto rico 2000 2021 a comparison with surveillance epidemiology and end results seer database |
| topic | colorectal cancer disparities early‐onset colorectal cancer Hispanic racial and ethnic |
| url | https://doi.org/10.1002/cam4.70851 |
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