Fractional-Order PI Control of First Order Plants with Guaranteed Time Specifications
Cardiospheres (CSs) are self-assembling multicellular clusters from the cellular outgrowth from cardiac explants cultured in nonadhesive substrates. They contain a core of primitive, proliferating cells, and an outer layer of mesenchymal/stromal cells and differentiating cells that express cardiomyo...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Applied Mathematics |
| Online Access: | http://dx.doi.org/10.1155/2013/197186 |
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| author | F. J. Castillo-Garcia A. San Millan-Rodriguez V. Feliu-Batlle L. Sanchez-Rodriguez |
| author_facet | F. J. Castillo-Garcia A. San Millan-Rodriguez V. Feliu-Batlle L. Sanchez-Rodriguez |
| author_sort | F. J. Castillo-Garcia |
| collection | DOAJ |
| description | Cardiospheres (CSs) are self-assembling multicellular clusters from the cellular outgrowth from cardiac explants cultured in nonadhesive substrates. They contain a core of primitive, proliferating cells, and an outer layer of mesenchymal/stromal cells and differentiating cells that express cardiomyocyte proteins and connexin 43. Because CSs contain both primitive cells and committed progenitors for the three major cell types present in the heart, that is, cardiomyocytes, endothelial cells, and smooth muscle cells, and because they are derived from percutaneous endomyocardial biopsies, they represent an attractive cell source for cardiac regeneration. In preclinical studies, CS-derived cells (CDCs) delivered to infarcted hearts resulted in improved cardiac function. CDCs have been tested safely in an initial phase-1 clinical trial in patients after myocardial infarction. Whether or not CDCs are superior to purified populations, for example, c-kit+ cardiac stem cells, or to gene therapy approaches for cardiac regeneration remains to be evaluated. |
| format | Article |
| id | doaj-art-cbc68cf04f4442b38d5c3dbc7d04efeb |
| institution | Kabale University |
| issn | 1110-757X 1687-0042 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Applied Mathematics |
| spelling | doaj-art-cbc68cf04f4442b38d5c3dbc7d04efeb2025-02-03T06:07:11ZengWileyJournal of Applied Mathematics1110-757X1687-00422013-01-01201310.1155/2013/197186197186Fractional-Order PI Control of First Order Plants with Guaranteed Time SpecificationsF. J. Castillo-Garcia0A. San Millan-Rodriguez1V. Feliu-Batlle2L. Sanchez-Rodriguez3Ayssel Mecatronica, St/Pedro Pardo 23, 13195 Poblete (Ciudad Real), SpainDepartment of Electrical, Electronics, Control Engineering and Communications, Castilla-La Mancha University, Av. Camilo Jose Cela s/n, 13071 Ciudad Real, SpainDepartment of Electrical, Electronics, Control Engineering and Communications, Castilla-La Mancha University, Av. Camilo Jose Cela s/n, 13071 Ciudad Real, SpainSchool of Industrial Engineering, Castilla-La Mancha University, Tecnology Campus ‘Antigua Fabrica de Armas’ s/n, 45071 Toledo, SpainCardiospheres (CSs) are self-assembling multicellular clusters from the cellular outgrowth from cardiac explants cultured in nonadhesive substrates. They contain a core of primitive, proliferating cells, and an outer layer of mesenchymal/stromal cells and differentiating cells that express cardiomyocyte proteins and connexin 43. Because CSs contain both primitive cells and committed progenitors for the three major cell types present in the heart, that is, cardiomyocytes, endothelial cells, and smooth muscle cells, and because they are derived from percutaneous endomyocardial biopsies, they represent an attractive cell source for cardiac regeneration. In preclinical studies, CS-derived cells (CDCs) delivered to infarcted hearts resulted in improved cardiac function. CDCs have been tested safely in an initial phase-1 clinical trial in patients after myocardial infarction. Whether or not CDCs are superior to purified populations, for example, c-kit+ cardiac stem cells, or to gene therapy approaches for cardiac regeneration remains to be evaluated.http://dx.doi.org/10.1155/2013/197186 |
| spellingShingle | F. J. Castillo-Garcia A. San Millan-Rodriguez V. Feliu-Batlle L. Sanchez-Rodriguez Fractional-Order PI Control of First Order Plants with Guaranteed Time Specifications Journal of Applied Mathematics |
| title | Fractional-Order PI Control of First Order Plants with Guaranteed Time Specifications |
| title_full | Fractional-Order PI Control of First Order Plants with Guaranteed Time Specifications |
| title_fullStr | Fractional-Order PI Control of First Order Plants with Guaranteed Time Specifications |
| title_full_unstemmed | Fractional-Order PI Control of First Order Plants with Guaranteed Time Specifications |
| title_short | Fractional-Order PI Control of First Order Plants with Guaranteed Time Specifications |
| title_sort | fractional order pi control of first order plants with guaranteed time specifications |
| url | http://dx.doi.org/10.1155/2013/197186 |
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