Cytotoxic acylphloroglucinols from the aerial parts of Hypericum hirsutum L. (Hypericaceae)
A phytochemical investigation of the dichloromethane extract of the aerial parts of Hypericum hirsutum L. led to isolating the main polyprenylated acylphloroglucinols (1 and 2). The compounds were identified employing spectral methods (HRMS, 1D, and 2D NMR, IR, UV) as adsecohyperforin (1) and secohy...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2025-03-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/148154/download/pdf/ |
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| author | Zlatina Kokanova-Nedialkova Georgi Momekov Paraskev T. Nedialkov |
| author_facet | Zlatina Kokanova-Nedialkova Georgi Momekov Paraskev T. Nedialkov |
| author_sort | Zlatina Kokanova-Nedialkova |
| collection | DOAJ |
| description | A phytochemical investigation of the dichloromethane extract of the aerial parts of Hypericum hirsutum L. led to isolating the main polyprenylated acylphloroglucinols (1 and 2). The compounds were identified employing spectral methods (HRMS, 1D, and 2D NMR, IR, UV) as adsecohyperforin (1) and secohyperforin (2), respectively. The MS/MS fragmentation of both compounds and NMR spectral data of 1 are described here for the first time. These natural products were found for the second time in a plant source. The cytotoxicity of isolated compounds was established on a panel of tumor cell lines (MDA-MB, EJ, and HL-60) and was determined using MTT-based assays. Both components showed higher cytotoxicity (IC50 = 0.27–4.85 µM) than the positive control etoposide (IC50 = 1.27–8.42 µM), making them promising candidates for new chemotherapeutic drugs. |
| format | Article |
| id | doaj-art-cbc26f013ce3482183674a6a00a43d61 |
| institution | Kabale University |
| issn | 2603-557X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj-art-cbc26f013ce3482183674a6a00a43d612025-08-20T03:40:22ZengPensoft PublishersPharmacia2603-557X2025-03-01721710.3897/pharmacia.72.e148154148154Cytotoxic acylphloroglucinols from the aerial parts of Hypericum hirsutum L. (Hypericaceae)Zlatina Kokanova-Nedialkova0Georgi Momekov1Paraskev T. Nedialkov2Medical University of SofiaMedical University of SofiaMedical University of SofiaA phytochemical investigation of the dichloromethane extract of the aerial parts of Hypericum hirsutum L. led to isolating the main polyprenylated acylphloroglucinols (1 and 2). The compounds were identified employing spectral methods (HRMS, 1D, and 2D NMR, IR, UV) as adsecohyperforin (1) and secohyperforin (2), respectively. The MS/MS fragmentation of both compounds and NMR spectral data of 1 are described here for the first time. These natural products were found for the second time in a plant source. The cytotoxicity of isolated compounds was established on a panel of tumor cell lines (MDA-MB, EJ, and HL-60) and was determined using MTT-based assays. Both components showed higher cytotoxicity (IC50 = 0.27–4.85 µM) than the positive control etoposide (IC50 = 1.27–8.42 µM), making them promising candidates for new chemotherapeutic drugs.https://pharmacia.pensoft.net/article/148154/download/pdf/ |
| spellingShingle | Zlatina Kokanova-Nedialkova Georgi Momekov Paraskev T. Nedialkov Cytotoxic acylphloroglucinols from the aerial parts of Hypericum hirsutum L. (Hypericaceae) Pharmacia |
| title | Cytotoxic acylphloroglucinols from the aerial parts of Hypericum hirsutum L. (Hypericaceae) |
| title_full | Cytotoxic acylphloroglucinols from the aerial parts of Hypericum hirsutum L. (Hypericaceae) |
| title_fullStr | Cytotoxic acylphloroglucinols from the aerial parts of Hypericum hirsutum L. (Hypericaceae) |
| title_full_unstemmed | Cytotoxic acylphloroglucinols from the aerial parts of Hypericum hirsutum L. (Hypericaceae) |
| title_short | Cytotoxic acylphloroglucinols from the aerial parts of Hypericum hirsutum L. (Hypericaceae) |
| title_sort | cytotoxic acylphloroglucinols from the aerial parts of hypericum hirsutum l hypericaceae |
| url | https://pharmacia.pensoft.net/article/148154/download/pdf/ |
| work_keys_str_mv | AT zlatinakokanovanedialkova cytotoxicacylphloroglucinolsfromtheaerialpartsofhypericumhirsutumlhypericaceae AT georgimomekov cytotoxicacylphloroglucinolsfromtheaerialpartsofhypericumhirsutumlhypericaceae AT paraskevtnedialkov cytotoxicacylphloroglucinolsfromtheaerialpartsofhypericumhirsutumlhypericaceae |