High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice

High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice

Abstract Dietary composition can significantly influence health and lifespan, however, robust knowledge on which food components, at what concentration exert which long-term health effects is still incomplete. Here, we explored the effects of dietary protein intake on Ercc1 Δ/− DNA-repair-deficient...

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Main Authors: Ivar van Galen, Maria B. Birkisdóttir, Rutger A. Ozinga, Renata M. C. Brandt, Sander Barnhoorn, Sandra Imholz, Conny T. van Oostrom, Ricfrid W. G. N. van der Marel, Kimberly Smit, Yvonne M. A. Rijksen, Erwin Reiling, Harry van Steeg, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Metabolic Health and Disease
Online Access:https://doi.org/10.1038/s44324-025-00064-3
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