Modulation of TNF‐α mRNA stability by human antigen R and miR181s in sepsis‐induced immunoparalysis

Modulation of TNF‐α mRNA stability by human antigen R and miR181s in sepsis‐induced immunoparalysis

Abstract Immunoparalysis is an important pathological mechanism in sepsis. However, an effective small molecule therapy is lacking. Here, we show that ouabain, a Na+,K+‐ATPase ligand, can reverse immunoparalysis in vitro, in vivo, and in clinical samples. Notably, the effect of ouabain was criticall...

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Bibliographic Details
Main Authors: Cao Dan, Bian Jinjun, Hua Zi‐Chun, Ma Lin, Chen Wei, Zhang Xu, Zhou Ri, Cheng Shun, Sun Wen‐Zhu, Jiao Qing‐Cai, Yin Wu
Format: Article
Language:English
Published: Springer Nature 2014-12-01
Series:EMBO Molecular Medicine
Subjects:
human antigen R
immunoparalysis
microRNA181
ouabain
tumor necrosis factor α
Online Access:https://doi.org/10.15252/emmm.201404797
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