Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure

Abstract Recently, the incidence rate and mortality of various acute or chronic vascular occlusive diseases have increased yearly. As one of the most effective measures to treat them, vascular stents have been widely studied by researchers, and presently, the most commonly used is a drug-eluting ste...

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Main Authors: Songhao Liu, Juan Yan, Mengyu Gao, Hongxia Yang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BioMedical Engineering OnLine
Subjects:
Online Access:https://doi.org/10.1186/s12938-025-01337-0
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author Songhao Liu
Juan Yan
Mengyu Gao
Hongxia Yang
author_facet Songhao Liu
Juan Yan
Mengyu Gao
Hongxia Yang
author_sort Songhao Liu
collection DOAJ
description Abstract Recently, the incidence rate and mortality of various acute or chronic vascular occlusive diseases have increased yearly. As one of the most effective measures to treat them, vascular stents have been widely studied by researchers, and presently, the most commonly used is a drug-eluting stent, which reduces the process of rapid endothelialization because the drug is not selective. Fortunately, with the discovery and exploration of micro–nanostructures that can regulate cells selectively, reducing the incidence of "intravascular restenosis" and achieving rapid endothelialization simultaneously are possible through a special structure that cannot only improve endothelial cells (ECs), but also inhibit smooth muscle cells (SMCs). Therefore, this paper mainly introduces the preparation methods of micro–nanostructures used in the past, as well as the detection methods of EC and SMC. Then, the various functions of different dimensional structures for different cells are summarized and analyzed. Finally, the application of micro–nanostructure in future stent materials is summarized and proposed.
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institution Kabale University
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publishDate 2025-01-01
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series BioMedical Engineering OnLine
spelling doaj-art-cbbe4cf524c64d01a97b1c9363e2d6d22025-01-26T12:44:58ZengBMCBioMedical Engineering OnLine1475-925X2025-01-0124112210.1186/s12938-025-01337-0Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructureSonghao Liu0Juan Yan1Mengyu Gao2Hongxia Yang3Northwest Institute of Plateau Biology, Chinese Academy of SciencesDepartment of Pharmacy, Medical College of Qinghai UniversitySchool of Energy and Electrical Engineering, Qinghai UniversityNorthwest Institute of Plateau Biology, Chinese Academy of SciencesAbstract Recently, the incidence rate and mortality of various acute or chronic vascular occlusive diseases have increased yearly. As one of the most effective measures to treat them, vascular stents have been widely studied by researchers, and presently, the most commonly used is a drug-eluting stent, which reduces the process of rapid endothelialization because the drug is not selective. Fortunately, with the discovery and exploration of micro–nanostructures that can regulate cells selectively, reducing the incidence of "intravascular restenosis" and achieving rapid endothelialization simultaneously are possible through a special structure that cannot only improve endothelial cells (ECs), but also inhibit smooth muscle cells (SMCs). Therefore, this paper mainly introduces the preparation methods of micro–nanostructures used in the past, as well as the detection methods of EC and SMC. Then, the various functions of different dimensional structures for different cells are summarized and analyzed. Finally, the application of micro–nanostructure in future stent materials is summarized and proposed.https://doi.org/10.1186/s12938-025-01337-0Micro–nanostructureECSMCStent
spellingShingle Songhao Liu
Juan Yan
Mengyu Gao
Hongxia Yang
Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure
BioMedical Engineering OnLine
Micro–nanostructure
EC
SMC
Stent
title Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure
title_full Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure
title_fullStr Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure
title_full_unstemmed Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure
title_short Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure
title_sort research progress in the regulation of endothelial cells and smooth muscle cells using a micro nanostructure
topic Micro–nanostructure
EC
SMC
Stent
url https://doi.org/10.1186/s12938-025-01337-0
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AT juanyan researchprogressintheregulationofendothelialcellsandsmoothmusclecellsusingamicronanostructure
AT mengyugao researchprogressintheregulationofendothelialcellsandsmoothmusclecellsusingamicronanostructure
AT hongxiayang researchprogressintheregulationofendothelialcellsandsmoothmusclecellsusingamicronanostructure