Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure
Abstract Recently, the incidence rate and mortality of various acute or chronic vascular occlusive diseases have increased yearly. As one of the most effective measures to treat them, vascular stents have been widely studied by researchers, and presently, the most commonly used is a drug-eluting ste...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | BioMedical Engineering OnLine |
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| Online Access: | https://doi.org/10.1186/s12938-025-01337-0 |
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| author | Songhao Liu Juan Yan Mengyu Gao Hongxia Yang |
| author_facet | Songhao Liu Juan Yan Mengyu Gao Hongxia Yang |
| author_sort | Songhao Liu |
| collection | DOAJ |
| description | Abstract Recently, the incidence rate and mortality of various acute or chronic vascular occlusive diseases have increased yearly. As one of the most effective measures to treat them, vascular stents have been widely studied by researchers, and presently, the most commonly used is a drug-eluting stent, which reduces the process of rapid endothelialization because the drug is not selective. Fortunately, with the discovery and exploration of micro–nanostructures that can regulate cells selectively, reducing the incidence of "intravascular restenosis" and achieving rapid endothelialization simultaneously are possible through a special structure that cannot only improve endothelial cells (ECs), but also inhibit smooth muscle cells (SMCs). Therefore, this paper mainly introduces the preparation methods of micro–nanostructures used in the past, as well as the detection methods of EC and SMC. Then, the various functions of different dimensional structures for different cells are summarized and analyzed. Finally, the application of micro–nanostructure in future stent materials is summarized and proposed. |
| format | Article |
| id | doaj-art-cbbe4cf524c64d01a97b1c9363e2d6d2 |
| institution | Kabale University |
| issn | 1475-925X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj-art-cbbe4cf524c64d01a97b1c9363e2d6d22025-01-26T12:44:58ZengBMCBioMedical Engineering OnLine1475-925X2025-01-0124112210.1186/s12938-025-01337-0Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructureSonghao Liu0Juan Yan1Mengyu Gao2Hongxia Yang3Northwest Institute of Plateau Biology, Chinese Academy of SciencesDepartment of Pharmacy, Medical College of Qinghai UniversitySchool of Energy and Electrical Engineering, Qinghai UniversityNorthwest Institute of Plateau Biology, Chinese Academy of SciencesAbstract Recently, the incidence rate and mortality of various acute or chronic vascular occlusive diseases have increased yearly. As one of the most effective measures to treat them, vascular stents have been widely studied by researchers, and presently, the most commonly used is a drug-eluting stent, which reduces the process of rapid endothelialization because the drug is not selective. Fortunately, with the discovery and exploration of micro–nanostructures that can regulate cells selectively, reducing the incidence of "intravascular restenosis" and achieving rapid endothelialization simultaneously are possible through a special structure that cannot only improve endothelial cells (ECs), but also inhibit smooth muscle cells (SMCs). Therefore, this paper mainly introduces the preparation methods of micro–nanostructures used in the past, as well as the detection methods of EC and SMC. Then, the various functions of different dimensional structures for different cells are summarized and analyzed. Finally, the application of micro–nanostructure in future stent materials is summarized and proposed.https://doi.org/10.1186/s12938-025-01337-0Micro–nanostructureECSMCStent |
| spellingShingle | Songhao Liu Juan Yan Mengyu Gao Hongxia Yang Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure BioMedical Engineering OnLine Micro–nanostructure EC SMC Stent |
| title | Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure |
| title_full | Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure |
| title_fullStr | Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure |
| title_full_unstemmed | Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure |
| title_short | Research progress in the regulation of endothelial cells and smooth muscle cells using a micro–nanostructure |
| title_sort | research progress in the regulation of endothelial cells and smooth muscle cells using a micro nanostructure |
| topic | Micro–nanostructure EC SMC Stent |
| url | https://doi.org/10.1186/s12938-025-01337-0 |
| work_keys_str_mv | AT songhaoliu researchprogressintheregulationofendothelialcellsandsmoothmusclecellsusingamicronanostructure AT juanyan researchprogressintheregulationofendothelialcellsandsmoothmusclecellsusingamicronanostructure AT mengyugao researchprogressintheregulationofendothelialcellsandsmoothmusclecellsusingamicronanostructure AT hongxiayang researchprogressintheregulationofendothelialcellsandsmoothmusclecellsusingamicronanostructure |